Works (11)
Updated: July 5th, 2023 15:44
2016 journal article
Integrating Transgenic Vector Manipulation with Clinical Interventions to Manage Vector-Borne Diseases
PLOS Computational Biology, 12(3), e1004695.
Ed(s): S. Alizon
MeSH headings : Animals; Combined Modality Therapy / methods; Communicable Diseases / epidemiology; Communicable Diseases / genetics; Communicable Diseases / virology; Computer Simulation; Genetic Engineering / methods; Humans; Insect Vectors / genetics; Models, Genetic; Treatment Outcome
TL;DR:
A framework to evaluate how clinical interventions can be integrated with transgenic vector manipulation strategies to prevent disease invasion and reduce disease incidence is developed and finds that for systems at the disease-endemic equilibrium, even modest perturbations induced by weak interventions can exhibit strong, albeit transient, epidemiological effects.
(via Semantic Scholar)
open access via journals.plos.org (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2015 journal article
Microevolutionary patterns in the common caiman predict macroevolutionary trends across extant crocodilians
BIOLOGICAL JOURNAL OF THE LINNEAN SOCIETY, 116(4), 834–846.
author keywords: adaptive radiation; Caiman crocodilus; geometric morphometrics; intraspecific variation; skull shape
TL;DR:
It is shown that C. crocodilus skulls vary along a narrow/broad-snouted continuum, with different subspecies strongly clustered at distinct ends of the continuum, suggesting that mechanisms of microevolutionary divergence within species may also explain broader patterns of diversification at higher taxonomic levels.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Reproductive interference explains persistence of aggression between species
Source: NC State University Libraries
Added: August 6, 2018
2014 journal article
Feasible Introgression of an Anti-pathogen Transgene into an Urban Mosquito Population without Using Gene-Drive
PLOS NEGLECTED TROPICAL DISEASES, 8(7).
MeSH headings : Aedes / genetics; Animals; Animals, Genetically Modified / genetics; Communicable Disease Control / methods; Insect Vectors / genetics; Mosquito Control / methods; Peru; Transgenes / genetics
TL;DR:
It is found that releasing mosquitoes carrying only an anti-pathogen construct can substantially decrease vector competence of a natural population, even at release ratios well below that required for the two currently feasible alternatives that rely on population reduction.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2014 journal article
Modeling oncolytic virotherapy: Is complete tumor-tropism too much of a good thing?
JOURNAL OF THEORETICAL BIOLOGY, 358, 166–178.
author keywords: Oncolytic viruses; Tumor elimination; Apparent competition; Vesicular stomatitis virus
MeSH headings : Humans; Models, Theoretical; Neoplasms / therapy; Oncolytic Virotherapy
TL;DR:
Viruses that infect some normal cells can potentially balance the competing goals of tumor elimination and minimizing the effects on normal cell populations, and could improve cancer treatment, with potentially fewer side-effects than conventional treatments such as chemotherapy.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2013 journal article
A Reduce and Replace Strategy for Suppressing Vector-Borne Diseases: Insights from a Deterministic Model
PLOS ONE, 8(9).
MeSH headings : Aedes / genetics; Aedes / physiology; Animals; Communicable Disease Control / methods; Dengue / prevention & control; Dengue / transmission; Female; Genetic Engineering; Insect Vectors / genetics; Insect Vectors / physiology; Male; Models, Theoretical; Time Factors
TL;DR:
It is shown that repeated R&R releases may lead to a temporary decrease in mosquito population density and, in the absence of fitness costs associated with the anti-pathogen gene, a long-term decrease in competent vector population density.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2013 journal article
A Reduce and Replace Strategy for Suppressing Vector-Borne Diseases: Insights from a Stochastic, Spatial Model
PLOS ONE, 8(12).
MeSH headings : Aedes / genetics; Aedes / virology; Animals; Animals, Genetically Modified; Calibration; Computer Simulation; Dengue Virus / physiology; Female; Genotype; Insect Vectors / virology; Male; Models, Theoretical; Ovum / metabolism; Stochastic Processes
TL;DR:
It is found this “reduce and replace” strategy can decrease the frequency of competent vectors below 50% two years after releases end, and appears preferable to releasing a strain carrying only a female-killing gene, which is likely to merely result in temporary population suppression.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2013 personal communication
The evolution of species recognition in competitive and mating contexts: the relative efficacy of alternative mechanisms of character displacement
Source: NC State University Libraries
Added: August 6, 2018
2013 journal article
The evolutionary consequences of interspecific aggression
Year in Evolutionary Biology, 1289, 48–68.
Source: NC State University Libraries
Added: August 6, 2018
2012 journal article
Assessing the Feasibility of Controlling Aedes aegypti with Transgenic Methods: A Model-Based Evaluation
PLoS ONE, 7(12), e52235.
Ed(s): N. Vasilakis
MeSH headings : Aedes / genetics; Aedes / physiology; Animals; Animals, Genetically Modified / genetics; Animals, Genetically Modified / physiology; Mosquito Control; Peru
TL;DR:
It is demonstrated that substantial suppression can nonetheless be achieved if releases are deployed in a uniform spatial pattern using strains combining multiple lethal elements, illustrating the importance of detailed spatial models for guiding genetic mosquito control strategies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2012 journal article
The biological control of disease vectors
Journal of Theoretical Biology, 309, 47–57.
Source: NC State University Libraries
Added: August 6, 2018
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