Kenichi W. Okamoto

Works (11)

Updated: July 5th, 2023 15:44

2016 journal article

Integrating Transgenic Vector Manipulation with Clinical Interventions to Manage Vector-Borne Diseases

PLOS Computational Biology, 12(3), e1004695.

By: K. Okamoto n, F. Gould n  & A. Lloyd n 

Ed(s): S. Alizon

MeSH headings : Animals; Combined Modality Therapy / methods; Communicable Diseases / epidemiology; Communicable Diseases / genetics; Communicable Diseases / virology; Computer Simulation; Genetic Engineering / methods; Humans; Insect Vectors / genetics; Models, Genetic; Treatment Outcome
TL;DR: A framework to evaluate how clinical interventions can be integrated with transgenic vector manipulation strategies to prevent disease invasion and reduce disease incidence is developed and finds that for systems at the disease-endemic equilibrium, even modest perturbations induced by weak interventions can exhibit strong, albeit transient, epidemiological effects. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2015 journal article

Microevolutionary patterns in the common caiman predict macroevolutionary trends across extant crocodilians

BIOLOGICAL JOURNAL OF THE LINNEAN SOCIETY, 116(4), 834–846.

By: K. Okamoto n, R. Langerhans  n, R. Rashid* & P. Amarasekare *

author keywords: adaptive radiation; Caiman crocodilus; geometric morphometrics; intraspecific variation; skull shape
TL;DR: It is shown that C. crocodilus skulls vary along a narrow/broad-snouted continuum, with different subspecies strongly clustered at distinct ends of the continuum, suggesting that mechanisms of microevolutionary divergence within species may also explain broader patterns of diversification at higher taxonomic levels. (via Semantic Scholar)
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14. Life Below Water (OpenAlex)
15. Life on Land (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Reproductive interference explains persistence of aggression between species

By: J. Drury, K. Okamoto, C. Anderson & G. Grether

Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

Feasible Introgression of an Anti-pathogen Transgene into an Urban Mosquito Population without Using Gene-Drive

PLOS NEGLECTED TROPICAL DISEASES, 8(7).

By: K. Okamoto n, M. Robert  n, F. Gould n  & A. Lloyd n 

MeSH headings : Aedes / genetics; Animals; Animals, Genetically Modified / genetics; Communicable Disease Control / methods; Insect Vectors / genetics; Mosquito Control / methods; Peru; Transgenes / genetics
TL;DR: It is found that releasing mosquitoes carrying only an anti-pathogen construct can substantially decrease vector competence of a natural population, even at release ratios well below that required for the two currently feasible alternatives that rely on population reduction. (via Semantic Scholar)
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11. Sustainable Cities and Communities (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 journal article

Modeling oncolytic virotherapy: Is complete tumor-tropism too much of a good thing?

JOURNAL OF THEORETICAL BIOLOGY, 358, 166–178.

By: K. Okamoto n, P. Amarasekare * & I. Petty n

author keywords: Oncolytic viruses; Tumor elimination; Apparent competition; Vesicular stomatitis virus
MeSH headings : Humans; Models, Theoretical; Neoplasms / therapy; Oncolytic Virotherapy
TL;DR: Viruses that infect some normal cells can potentially balance the competing goals of tumor elimination and minimizing the effects on normal cell populations, and could improve cancer treatment, with potentially fewer side-effects than conventional treatments such as chemotherapy. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2013 journal article

A Reduce and Replace Strategy for Suppressing Vector-Borne Diseases: Insights from a Deterministic Model

PLOS ONE, 8(9).

By: M. Robert  n, K. Okamoto n, A. Lloyd n  & F. Gould n 

MeSH headings : Aedes / genetics; Aedes / physiology; Animals; Communicable Disease Control / methods; Dengue / prevention & control; Dengue / transmission; Female; Genetic Engineering; Insect Vectors / genetics; Insect Vectors / physiology; Male; Models, Theoretical; Time Factors
TL;DR: It is shown that repeated R&R releases may lead to a temporary decrease in mosquito population density and, in the absence of fitness costs associated with the anti-pathogen gene, a long-term decrease in competent vector population density. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2013 journal article

A Reduce and Replace Strategy for Suppressing Vector-Borne Diseases: Insights from a Stochastic, Spatial Model

PLOS ONE, 8(12).

By: K. Okamoto n, M. Robert  n, A. Lloyd n  & F. Gould  n

MeSH headings : Aedes / genetics; Aedes / virology; Animals; Animals, Genetically Modified; Calibration; Computer Simulation; Dengue Virus / physiology; Female; Genotype; Insect Vectors / virology; Male; Models, Theoretical; Ovum / metabolism; Stochastic Processes
TL;DR: It is found this “reduce and replace” strategy can decrease the frequency of competent vectors below 50% two years after releases end, and appears preferable to releasing a strain carrying only a female-killing gene, which is likely to merely result in temporary population suppression. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2013 personal communication

The evolution of species recognition in competitive and mating contexts: the relative efficacy of alternative mechanisms of character displacement

By: K. Okamoto & G. Grether

Source: NC State University Libraries
Added: August 6, 2018

2013 journal article

The evolutionary consequences of interspecific aggression

Year in Evolutionary Biology, 1289, 48–68.

By: G. Grether, C. Anderson, J. Drury, A. Kirschel, N. Losin, K. Okamoto, K. Peiman

Source: NC State University Libraries
Added: August 6, 2018

2012 journal article

Assessing the Feasibility of Controlling Aedes aegypti with Transgenic Methods: A Model-Based Evaluation

PLoS ONE, 7(12), e52235.

By: M. Legros n, C. Xu n, K. Okamoto n, T. Scott *, A. Morrison *, A. Lloyd n , F. Gould n 

Ed(s): N. Vasilakis

MeSH headings : Aedes / genetics; Aedes / physiology; Animals; Animals, Genetically Modified / genetics; Animals, Genetically Modified / physiology; Mosquito Control; Peru
TL;DR: It is demonstrated that substantial suppression can nonetheless be achieved if releases are deployed in a uniform spatial pattern using strains combining multiple lethal elements, illustrating the importance of detailed spatial models for guiding genetic mosquito control strategies. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2012 journal article

The biological control of disease vectors

Journal of Theoretical Biology, 309, 47–57.

By: K. Okamoto & P. Amarasekare

Source: NC State University Libraries
Added: August 6, 2018

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