Mary Jo Burkhard

Works (15)

Updated: February 10th, 2025 14:29

2020 journal article

Multicenter flow cytometry proficiency testing of canine blood and lymph node samples

Veterinary Clinical Pathology, 49(2), 249–257.

By: K. Meichner*, T. Stokol *, J. Tarigo*, A. Avery *, M. Burkhard*, S. Comazzi *, J. Fogle n, D. Stowe n  ...

author keywords: assay performance; dog; external laboratory quality assessment; immunophenotyping
MeSH headings : Animals; Cross-Sectional Studies; Dog Diseases / blood; Dog Diseases / diagnosis; Dog Diseases / pathology; Dogs; Flow Cytometry / standards; Flow Cytometry / veterinary; Hematologic Neoplasms / diagnosis; Hematologic Neoplasms / pathology; Hematologic Neoplasms / veterinary; Immunophenotyping / veterinary; Laboratory Proficiency Testing / standards; Lymph Nodes / pathology; Lymphoproliferative Disorders / diagnosis; Lymphoproliferative Disorders / pathology; Lymphoproliferative Disorders / veterinary
topics (OpenAlex): Veterinary Oncology Research; Mycobacterium research and diagnosis; Microbial infections and disease research
TL;DR: Lymphoproliferations were readily identified by FC, but identification of the categories of hematolymphoid neoplasia in fresh samples or archived files was variable, indicating a need for a more standardized approach to maximize the enormous potential of FC in veterinary medicine. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: April 20, 2020

2007 article

FIV Infection Induces Unique Changes in Phenotype and Cellularity in the Medial Iliac Lymph Node and Intestinal IEL

Howard, K. E., & Burkhard, M. J. (2007, May 1). AIDS Research and Human Retroviruses.

By: K. Howard n & M. Burkhard*

MeSH headings : Animals; CD4-Positive T-Lymphocytes / immunology; CD8-Positive T-Lymphocytes / immunology; Cats; Female; Flow Cytometry; Immunity, Mucosal; Immunodeficiency Virus, Feline; Intestinal Mucosa / immunology; Intestinal Mucosa / pathology; Lentivirus Infections / immunology; Lentivirus Infections / pathology; Lymph Nodes / immunology; Lymph Nodes / pathology; Male; Phenotype
topics (OpenAlex): Immune Cell Function and Interaction; T-cell and B-cell Immunology; Systemic Lupus Erythematosus Research
TL;DR: The findings expand the array of immune alterations induced by lentiviral infection and indicate that characterization of multiple mucosal sites will be necessary to fully understand the pathogenesis of HIV-1 infection. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2005 article

Methodology for isolation and phenotypic characterization of feline small intestinal leukocytes

Howard, K. E., Fisher, I. L., Dean, G. A., & Burkhard, M. J. (2005, June 10). Journal of Immunological Methods.

By: K. Howard n, I. Fisher n, G. Dean n & M. Burkhard*

author keywords: feline; small intestine; IEL; LPL; Peyer's patches; phenotype
MeSH headings : Animals; Antibodies, Monoclonal; Biomarkers; Cats; Cell Separation / methods; Flow Cytometry / methods; Immunophenotyping / methods; Intestinal Mucosa / cytology; Intestinal Mucosa / immunology; Intestine, Small / cytology; Leukocytes / cytology; Leukocytes / immunology; Receptors, Interleukin-2 / immunology
topics (OpenAlex): Immune Cell Function and Interaction; T-cell and B-cell Immunology; Immunotherapy and Immune Responses
TL;DR: The phenotypic distribution of feline intestinal leukocytes was similar to that found in other species such as humans, macaques and mice and no differences were found between the phenotype of mucosal leukocyte populations from specific pathogen free or random source cats. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2004 article

Assessment of CD4+ and CD8+ IFN-gamma producing cells by ELISPOT in naïve and FIV-infected cats

Sirriyah, J., Dean, G. A., LaVoy, A., & Burkhard, M. J. (2004, August 24). Veterinary Immunology and Immunopathology.

By: J. Sirriyah n, G. Dean n, A. LaVoy n & M. Burkhard*

author keywords: feline immunodeficiency virus; ELISPOT; CD4+; CD8+; T-cell subsets
MeSH headings : Animals; CD4-Positive T-Lymphocytes / immunology; CD8-Positive T-Lymphocytes / immunology; Cats; Concanavalin A / immunology; Feline Acquired Immunodeficiency Syndrome / blood; Feline Acquired Immunodeficiency Syndrome / immunology; Immunodeficiency Virus, Feline / immunology; Immunoenzyme Techniques / veterinary; Interferon-gamma / biosynthesis; Interferon-gamma / immunology; Lymphocyte Activation / immunology; Lymphocyte Count / veterinary
topics (OpenAlex): HIV Research and Treatment; Herpesvirus Infections and Treatments; T-cell and B-cell Immunology
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2004 article

Oral Immunization with RecombinantListeria monocytogenesControls Virus Load after Vaginal Challenge with Feline Immunodeficiency Virus

Stevens, R., Howard, K. E., Nordone, S., Burkhard, M. J., & Dean, G. A. (2004, July 14). Journal of Virology.

By: R. Stevens, K. Howard  n, S. Nordone, M. Burkhard* & G. Dean*

MeSH headings : Administration, Oral; Animals; Antibodies, Viral / biosynthesis; Cats; Feline Acquired Immunodeficiency Syndrome / prevention & control; Feline Acquired Immunodeficiency Syndrome / virology; Female; Gene Products, gag / genetics; Gene Products, gag / immunology; Immunization; Immunodeficiency Virus, Feline / isolation & purification; Immunoglobulin A / biosynthesis; Immunoglobulin G / biosynthesis; Intestinal Mucosa / immunology; Listeria monocytogenes / genetics; Lymph Nodes / immunology; Lymphocyte Depletion; Proviruses / isolation & purification; Vaccines, Synthetic / immunology; Viral Load; Viral Vaccines / immunology
topics (OpenAlex): Food Allergy and Anaphylaxis Research; HIV Research and Treatment; Herpesvirus Infections and Treatments
TL;DR: It is demonstrated that recombinant L. monocytogenes conferred some control of viral load after vaginal challenge with FIV, using the feline immunodeficiency virus (FIV) model of HIV. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2004 article

Peptide mapping of feline immunodeficiency virus by IFN-γ ELISPOT

Dean, G. A., LaVoy, A., & Burkhard, M. J. (2004, June 2). Veterinary Immunology and Immunopathology.

By: G. Dean n, A. LaVoy n & M. Burkhard n

author keywords: feline; peptide; ELISPOT; feline immunodeficiency virus; T-cell
MeSH headings : Amino Acid Sequence; Animals; Antibodies, Monoclonal / immunology; Antibody Specificity / immunology; Cats; Feline Acquired Immunodeficiency Syndrome / immunology; Feline Acquired Immunodeficiency Syndrome / virology; Gene Products, env / immunology; Gene Products, gag / immunology; Immunodeficiency Virus, Feline / immunology; Immunoenzyme Techniques / methods; Immunoenzyme Techniques / veterinary; Interferon-gamma / genetics; Interferon-gamma / immunology; Molecular Sequence Data; Peptide Fragments / immunology; Peptide Library; Peptide Mapping; RNA, Messenger / chemistry; RNA, Messenger / genetics; RNA-Directed DNA Polymerase / immunology; Reverse Transcriptase Polymerase Chain Reaction / veterinary
topics (OpenAlex): HIV Research and Treatment; Herpesvirus Infections and Treatments; Immunotherapy and Immune Responses
TL;DR: This work has developed a feline IFN-γ ELISPOT assay and used it to determine FIV-specific T-cell epitopes recognized by infected cats and its results will be useful in assessing cell-mediated responses to experimental FIV vaccines. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2003 article

Transmission and Immunopathogenesis of FIV in Cats as a Model for HIV

Burkhard, M., & Dean, G. (2003, January 1). Current HIV Research.

By: M. Burkhard n & G. Dean*

author keywords: FIV; immunopathogenesis; HIV animal model; mucosal transmission; feline
MeSH headings : Animals; Cats; Disease Models, Animal; Disease Transmission, Infectious; Feline Acquired Immunodeficiency Syndrome / immunology; Feline Acquired Immunodeficiency Syndrome / pathology; Feline Acquired Immunodeficiency Syndrome / transmission; Female; HIV Infections / immunology; HIV Infections / pathology; HIV Infections / transmission; HIV-1 / genetics; HIV-1 / growth & development; Humans; Immunodeficiency Virus, Feline / genetics; Immunodeficiency Virus, Feline / growth & development; Infectious Disease Transmission, Vertical; Virus Replication
topics (OpenAlex): HIV Research and Treatment; Rabies epidemiology and control; Herpesvirus Infections and Treatments
TL;DR: This review will encompass areas specific to transmission and immunopathogenesis, which allow investigators to model specific aspects of HIV infection in a highly relevant and relatively inexpensive animal model. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2002 conference paper

Blood lactate: potential applications in avian medicine

Proceedings Annual Conference of the Association of Avian Veterinarians, 19–22.

By: R. De Voe, K. Flammer, L. Degernes & M. Burkhard

Source: NC State University Libraries
Added: August 6, 2018

2002 article

Evaluation of FIV protein-expressing VEE-replicon vaccine vectors in cats

Burkhard, M. J., Valenski, L., Leavell, S., Dean, G. A., & Tompkins, W. A. F. (2002, December 1). Vaccine.

By: M. Burkhard n, L. Valenski n, S. Leavell n, G. Dean n & W. Tompkins n

author keywords: Venezuelan equine encephalitis (VEE) virus; VEE-replicon particles; feline immunodeficiency virus (FIV)
MeSH headings : Animals; Antibodies, Viral / biosynthesis; Antibodies, Viral / blood; Cats; Encephalitis Virus, Venezuelan Equine / genetics; Evaluation Studies as Topic; Feline Acquired Immunodeficiency Syndrome / immunology; Female; Genetic Vectors / genetics; Glycoproteins; Immunodeficiency Virus, Feline / immunology; T-Lymphocyte Subsets / immunology; T-Lymphocytes, Cytotoxic / immunology; T-Lymphocytes, Regulatory / immunology; Vaccines, Synthetic / administration & dosage; Vaccines, Synthetic / immunology; Vagina / immunology; Vagina / virology; Viral Envelope Proteins; Viral Vaccines / administration & dosage; Viral Vaccines / immunology; Viremia / blood
topics (OpenAlex): HIV Research and Treatment; Mosquito-borne diseases and control; Virology and Viral Diseases
TL;DR: Despite induction of Fiv-specific immune responses and nonspecific suppressor responses, all cats became infected following vaginal challenge with high dose, pathogenic cell-associated FIV-NCSU, although relative early maintenance of CD4+ cells was seen in F IV-immunized cats. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2002 article

Kinetics of Early FIV Infection in Cats Exposed via the Vaginal versus Intravenous Route

Burkhard, M. J., Mathiason, C. K., O'Halloran, K., & Hoover, E. A. (2002, February 10). AIDS Research and Human Retroviruses.

By: M. Burkhard n, C. Mathiason *, K. O'Halloran * & E. Hoover*

MeSH headings : Animals; Antibodies, Viral / blood; Cats; Cell Division; DNA, Viral / blood; Feline Acquired Immunodeficiency Syndrome / epidemiology; Feline Acquired Immunodeficiency Syndrome / immunology; Feline Acquired Immunodeficiency Syndrome / virology; Female; Immunodeficiency Virus, Feline / genetics; Immunodeficiency Virus, Feline / immunology; Immunodeficiency Virus, Feline / isolation & purification; Immunodeficiency Virus, Feline / physiology; Incidence; Injections, Intravenous; Kinetics; Leukocytes, Mononuclear / virology; Lymph Nodes / virology; RNA, Viral / blood; Spleen / virology; T-Lymphocyte Subsets; Vagina / virology; Viremia
topics (OpenAlex): HIV Research and Treatment; Herpesvirus Infections and Treatments; Animal Disease Management and Epidemiology
TL;DR: The results establish that the kinetics of early FIV infection differ with route of exposure as well as virus isolate and that properties extrapolated from one virus isolate may not be universal. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2001 article

Evaluation of the Erythroid Regenerative Response in Two Different Models of Experimentally Induced Iron Deficiency Anemia

Burkhard, M. J., Brown, D. E., McGrath, J. P., Meador, V. P., Mayle, D. A., Keaton, M. J., … Sun, S. C. (2001, June 1). Veterinary Clinical Pathology.

By: M. Burkhard n, D. Brown*, J. McGrath *, V. Meador*, D. Mayle*, M. Keaton*, W. Hoffman*, J. Zimmermann*, D. Abbott*, S. Sun

author keywords: anemia; erythropoiesis; iron deficiency; rat; regenerative; Sprague Dawley
topics (OpenAlex): Iron Metabolism and Disorders; Hemoglobinopathies and Related Disorders; Erythrocyte Function and Pathophysiology
TL;DR: It is suggested that the availability of iron in the diet may modulate the pathogenesis of iron deficiency anemia and alter the efficiency of hemoglobin production following a hemolytic event. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2001 article

Feline Immunodeficiency Virus Gag- and Env-Specific Immune Responses after Vaginal versus Intravenous Infection

Burkhard, M. J., Mathiason, C. K., Bowdre, T., & Hoover, E. A. (2001, December 10). AIDS Research and Human Retroviruses.

By: M. Burkhard n, C. Mathiason *, T. Bowdre* & E. Hoover*

MeSH headings : Animals; Antibodies, Viral / biosynthesis; Cats; Feline Acquired Immunodeficiency Syndrome / transmission; Female; Flow Cytometry; Gene Products, gag / immunology; Glycoproteins / immunology; Immunodeficiency Virus, Feline / immunology; T-Lymphocytes, Cytotoxic / immunology; Vagina / immunology; Vagina / virology; Viral Envelope Proteins / immunology; Viral Load
topics (OpenAlex): HIV Research and Treatment; Herpesvirus Infections and Treatments; Animal Disease Management and Epidemiology
TL;DR: Qualitative differences in the immune responses following vaginal infection are found but no evidence that mucosal immune responses were enhanced in vaginally exposed cats, that local mucosal infection led to measurably greater immune responses in either compartment, or that more prominent immune responses correlated with lower viral burden is found. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2001 journal article

Intestinal and blood parasites in Amazon parrots destined for relocation in Guatemala

Journal of Zoo and Wildlife Medicine, 32(1), 71–73.

By: M. Rooney, M. Burkhard, E. Greiner, Q. Zeng & J. Johnson

Source: NC State University Libraries
Added: August 6, 2018

1999 journal article

Feline immunodeficiency virus (FIV): Clinical manifestations and management part 2

Feline Practice, 27(1), 10–14.

By: M. Burkhard & E. Hoover

Source: NC State University Libraries
Added: August 6, 2018

1998 journal article

Feline Immunodeficiency Virus (FIV): Immunopathogenesis

Feline Practice, 26(6), 10–13.

By: M. Burkhard & E. Hoover

Source: NC State University Libraries
Added: August 6, 2018

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