Robert J. Cain

Works (3)

Updated: July 5th, 2023 16:02

2000 article

Synthesis and Properties of Uniquely Modified Oligoribonucleotides: Yeast TrnaPheFragments with 6-Methyluridine and 5,6-Dimethyluridine at Site-Specific Positions

Sochacka, E., Czerwinska, G., Guenther, R., Cain, R., Agris, P. F., & Malkiewicz, A. (2000, March 1). Nucleosides Nucleotides & Nucleic Acids.

By: E. Sochacka *, G. Czerwinska*, R. Guenther n, R. Cain n, P. Agris n & A. Malkiewicz*

MeSH headings : Anticodon; Magnetic Resonance Spectroscopy; Methylation; Molecular Conformation; Oligoribonucleotides / chemical synthesis; Oligoribonucleotides / chemistry; Organophosphorus Compounds / chemistry; RNA, Transfer, Phe / chemistry; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Uridine / analogs & derivatives; Uridine / chemistry; Yeasts / chemistry
topics (OpenAlex): DNA and Nucleic Acid Chemistry; RNA and protein synthesis mechanisms; RNA modifications and cancer
TL;DR: Stability when the modified uridine is in a loop is sequence context dependent, and can not, at this time, be predicted from the location in the loop, but decrease in RNA duplex stability is predictable. (via Semantic Scholar)
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Added: August 6, 2018

1999 article

Single atom modification (O → S) of tRNA confers ribosome binding

ASHRAF, S. S. A. L. M. A. N., SOCHACKA, E. L. Z. B. I. E. T. A., CAIN, R. O. B. E. R. T., GUENTHER, R. I. C. H. A. R. D., MALKIEWICZ, A. N. D. R. Z. E. J., & AGRIS, P. A. U. L. F. (1999, February 1). RNA.

By: S. Ashraf n, E. Sochacka *, R. Cain n, R. Guenther n, A. Malkiewicz* & P. Agris n

author keywords: 2-thiouridine; anticodon conformation; anticodon stem loop analogs; nucleoside modifications; ribosome; translation; tRNA(LyS)
MeSH headings : Aldehydes / metabolism; Anticodon / genetics; Butanones; Escherichia coli / metabolism; Humans; Magnetic Resonance Spectroscopy; Nucleic Acid Conformation; Nucleic Acid Denaturation / genetics; Nucleic Acid Hybridization / genetics; RNA, Fungal / genetics; RNA, Transfer, Lys / chemistry; RNA, Transfer, Lys / genetics; Ribosomes / metabolism; Spectrum Analysis; Temperature; Thiouridine / analogs & derivatives; Thiouridine / metabolism
topics (OpenAlex): RNA modifications and cancer; RNA and protein synthesis mechanisms; Peptidase Inhibition and Analysis
TL;DR: It is concluded that s2U34 in tRNALysSUU and in other s2 U34-containing tRNAs is critical for generating an anticodon conformation that leads to effective codon interaction in all organisms. (via Semantic Scholar)
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1999 article

Structural and functional roles of the N1- and N3-protons of   at tRNA's position 39

Yarian, C. S., Basti, M. M., Cain, R. J., Ansari, G., Guenther, R. H., Sochacka, E., … Agris, P. F. (1999, September 1). Nucleic Acids Research.

By: C. Yarian n, M. Basti*, R. Cain n, G. Ansari n, R. Guenther n, E. Sochacka *, G. Czerwinska*, A. Malkiewicz*, P. Agris*

MeSH headings : Anticodon / chemistry; Genes, Fungal / genetics; Magnetic Resonance Spectroscopy; Nucleic Acid Conformation; Protons; Pseudouridine / chemistry; RNA, Ribosomal, 16S / chemistry; RNA, Transfer, Phe / chemistry; Ribosomes / chemistry; Structure-Activity Relationship; Temperature; Thermodynamics; Uridine / chemistry; Yeasts / genetics
topics (OpenAlex): RNA and protein synthesis mechanisms; RNA modifications and cancer; Mass Spectrometry Techniques and Applications
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Source: Web Of Science
Added: August 6, 2018

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