Janet L. Dow

Works (8)

Updated: July 5th, 2023 16:02

2004 journal article

B7(+)CTLA4(+) T cells engage in T-T cell interactions that mediate apoptosis: a model for lentivirus-induced T cell depletion

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 98(3-4), 203–214.

By: T. Vahlenkamp n, M. Bull n, J. Dow n, E. Collisson*, B. Winslow, A. Phadke*, W. Tompkins n, M. Tompkins n

author keywords: FIV; apoptosis; 137 costimulatory molecules; CTLA4
MeSH headings : Animals; Antigens, CD / biosynthesis; Antigens, CD / immunology; Antigens, Differentiation / biosynthesis; Antigens, Differentiation / immunology; Apoptosis / immunology; B7-1 Antigen / biosynthesis; B7-1 Antigen / immunology; B7-2 Antigen; CTLA-4 Antigen; Cats; Cell Communication / immunology; Concanavalin A / immunology; Feline Acquired Immunodeficiency Syndrome / immunology; Flow Cytometry / veterinary; Immunodeficiency Virus, Feline / immunology; In Situ Nick-End Labeling / veterinary; Ionomycin / immunology; Lymphocyte Activation / immunology; Membrane Glycoproteins / biosynthesis; Membrane Glycoproteins / immunology; Specific Pathogen-Free Organisms; T-Lymphocytes / immunology; T-Lymphocytes / virology; Tetradecanoylphorbol Acetate / immunology
TL;DR: The hypothesis that the chronic expansion of B7+CTLA4+ LN T cells in infected cats allows for T-T cell interactions resulting in T cell depletion and eventually the development of AIDS is supported. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2004 article

Hypoglycemia-induced changes in cell death and cell proliferation in the organogenesis-stage embryonic mouse heart (Retracted article. See vol 76, pg 278, 2006)

Ghatnekar, G. S., Barnes, J. A., Dow, J. L., & Smoak, I. W. (2004, March). BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY, Vol. 70, pp. 121–131.

By: G. Ghatnekar n, J. Barnes n, J. Dow n & I. Smoak n

author keywords: embryonic heart; hypoglycemia; apoptosis; cell proliferation; flow cytometry; caspase-3; p53; PCNA
MeSH headings : Animals; Caspase 3; Caspases / metabolism; Cell Death; Cell Division; Flow Cytometry; Heart / embryology; Hypoglycemia / metabolism; Hypoglycemia / pathology; Immunohistochemistry; Mice; Organogenesis; Proliferating Cell Nuclear Antigen / metabolism; Tumor Suppressor Protein p53 / metabolism
TL;DR: Hypoglycemia reduces embryonic viability, induces significant cell death, and reduces cell proliferation in the E9.5 mouse heart, and these processes may involve active caspase-3 and p53. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2004 journal article

Spontaneous T cell apoptosis in feline immunodeficiency virus (FIV)-infected cats is inhibited by IL2 and anti-B7.1 antibodies

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 99(1-2), 25–37.

By: M. Bull n, T. Vahlenkamp n, J. Dow n, E. Collisson*, B. Winslow, A. Phadke*, M. Tompkins n, W. Tompkins n

author keywords: FIV; apoptosis; IL2; B7 co-stimulatory molecules; CTLA4
MeSH headings : Animals; Antibodies, Blocking / immunology; Antigens, CD / immunology; Apoptosis / drug effects; Apoptosis / immunology; B7-2 Antigen; CD4-Positive T-Lymphocytes / immunology; CD4-Positive T-Lymphocytes / pathology; CD4-Positive T-Lymphocytes / virology; CD8-Positive T-Lymphocytes / immunology; CD8-Positive T-Lymphocytes / pathology; CD8-Positive T-Lymphocytes / virology; Cats; Feline Acquired Immunodeficiency Syndrome / blood; Feline Acquired Immunodeficiency Syndrome / immunology; Immunodeficiency Virus, Feline / genetics; Immunodeficiency Virus, Feline / immunology; In Situ Nick-End Labeling / veterinary; Interleukin-2 / immunology; Interleukin-2 / pharmacology; Lymph Nodes / immunology; Lymphocyte Activation / immunology; Membrane Glycoproteins / antagonists & inhibitors; Membrane Glycoproteins / immunology; RNA, Viral / chemistry; RNA, Viral / genetics; Reverse Transcriptase Polymerase Chain Reaction / veterinary; Specific Pathogen-Free Organisms
TL;DR: A role of B7 signaling in the increased spontaneous apoptosis observed in LN T cells from FIV-infected animals is suggested. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2002 article

Feline immunodeficiency virus infection is characterized by B7(+)CTLA4(+) T cell apoptosis

Tompkins, M. B., Bull, M. E., Dow, J. L., Ball, J. M., Collisson, E. W., Winslow, B. J., … Tompkins, W. A. (2002, April 15). JOURNAL OF INFECTIOUS DISEASES, Vol. 185, pp. 1077–1093.

By: M. Tompkins n, M. Bull n, J. Dow n, J. Ball*, E. Collisson*, B. Winslow, A. Phadke*, T. Vahlenkamp n, W. Tompkins n

MeSH headings : Abatacept; Animals; Antigens, CD / analysis; Antigens, Differentiation / analysis; Apoptosis; B7-1 Antigen / analysis; B7-2 Antigen; CTLA-4 Antigen; Cats; Feline Acquired Immunodeficiency Syndrome / immunology; Immunoconjugates; In Situ Nick-End Labeling; Membrane Glycoproteins / analysis; T-Lymphocytes / physiology
TL;DR: Data support the hypothesis that lymph node apoptosis and immune deterioration in FIV-infected cats results from chronic B7.1- and/or B.2-CTLA4-mediated T-T interactions. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2001 conference paper

B7.1/B7.2 and CTLA4 expression on feline T cells in vitro correlates with apoptosis

Journal of Leukocyte Biology, (2001), 255.

By: T. Vahlenkamp, M. Bull, J. Dow, J. Anderson, M. Tompkins & W. Tompkins

Source: NC State University Libraries
Added: August 6, 2018

2001 conference paper

Feline immunodeficiency virus (FIV) infection induces B7(+)CTLA4(+) T cell apoptosis: A model for T cell depletion and immunodeficiency

Journal of Leukocyte Biology, (2001), 254.

By: M. Tompkins, M. Bull, J. Dow & W. Tompkins

Source: NC State University Libraries
Added: August 6, 2018

1999 journal article

Progressive expansion of an L-selectin-negative CD8 cell with anti-feline immunodeficiency virus (FIV) suppressor function in the circulation of FIV-infected cats

JOURNAL OF INFECTIOUS DISEASES, 180(5), 1503–1513.

By: D. Gebhard n, J. Dow n, T. Childers n, J. Alvelo n, M. Tompkins n & W. Tompkins n

MeSH headings : Animals; CD8-Positive T-Lymphocytes / immunology; Cats; Feline Acquired Immunodeficiency Syndrome / immunology; Immunodeficiency Virus, Feline / immunology; Immunophenotyping; Integrins / metabolism; L-Selectin / analysis; Leukocytes, Mononuclear / immunology; Lymph Nodes / immunology; T-Lymphocyte Subsets / immunology; T-Lymphocytes, Regulatory / immunology
TL;DR: The progressive expansion of the CD8alpha+betaloCD62L- effector subset cells in FIV-infected cats parallels that seen in human immunodeficiency virus (HIV)-infected patients, suggesting that failure in homeostatic mechanisms regulating lymphocyte activation or trafficking (or both) may be a consequence of both HIV and FIV infections. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1999 journal article

Toward a canine model of atopic dermatitis: amplification of cytokine-gene transcripts in the skin of atopic dogs

EXPERIMENTAL DERMATOLOGY, 8(3), 204–211.

By: T. Olivry* , G. Dean n, M. Tompkins n, J. Dow n & P. Moore *

author keywords: skin; atopic dermatitis; dogs; canine; cytokine; interleukin; interferon
MeSH headings : Animals; Biopsy; Cytokines / genetics; Dermatitis, Atopic / genetics; Dermatitis, Atopic / pathology; Disease Models, Animal; Dogs; Interferon-gamma / genetics; Interleukin-12 / genetics; Interleukin-2 / genetics; Interleukin-4 / genetics; Interleukin-5 / genetics; RNA, Messenger / genetics; RNA, Messenger / metabolism; Reverse Transcriptase Polymerase Chain Reaction; Skin / metabolism; Skin / pathology; Transcription, Genetic
TL;DR: The transcription of type‐2 cytokine‐genes in the skin of dogs with AD is established for the first time, to confirm whether or not canine AD could be considered an immunological model for a human disease. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

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