Wetonia B. Grenther

Works (4)

Updated: July 5th, 2023 16:02

2002 journal article

Lactobacillus plantarum 299V in the treatment and prevention of spontaneous colitis in interleukin-10-deficient mice

INFLAMMATORY BOWEL DISEASES, 8(2), 71–80.

By: M. Schultz *, C. Veltkamp, L. Dieleman, W. Grenther*, P. Wyrick n, S. Tonkonogy*, R. Sartor *

author keywords: probiotics; experimental colitis; interleukin-10 knockout mice
MeSH headings : Administration, Oral; Animals; Colitis / immunology; Colitis / microbiology; Colitis / pathology; Colitis / prevention & control; Disease Models, Animal; Interleukin-10 / deficiency; Interleukin-10 / genetics; Lactobacillus / classification; Lactobacillus / physiology; Mice; Mice, Inbred C57BL; Mice, Knockout; Probiotics / administration & dosage; Probiotics / therapeutic use; Specific Pathogen-Free Organisms
TL;DR: Results demonstrate that L. plantarum can attenuate immune-mediated colitis and suggest a potential therapeutic role for this agent in clinical inflammatory bowel diseases. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2001 article

Continuous stimulation by normal luminal bacteria is essential for the development and perpetuation of colitis in Tg is an element of 26 mice

Veltkamp, C., Tonkonogy, S. L., De Jong, Y. P., Albright, C., Grenther, W. B., Balish, E., … Sartor, R. B. (2001, March). GASTROENTEROLOGY, Vol. 120, pp. 900–913.

By: C. Veltkamp*, S. Tonkonogy n, Y. De Jong *, C. Albright*, W. Grenther n, E. Balish*, C. Terhorst *, R. Sartor *

MeSH headings : Animals; Bacterial Physiological Phenomena; Bone Marrow Transplantation; Colitis / microbiology; Colitis / pathology; Colitis / prevention & control; Colon / microbiology; Colon / pathology; Germ-Free Life; Immunocompetence / physiology; Intestinal Mucosa / cytology; Lymph Nodes / cytology; Mesentery; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Phenotype; T-Lymphocytes / physiology; T-Lymphocytes / transplantation; Wasting Syndrome / prevention & control
TL;DR: Activated T cells are present in the mucosa of BM-->GF Tg(epsilon26) mice but are incapable of inducing disease unless colonic bacteria are present, and pathogenic T cells require the continuous presence of Colonic bacteria to sustain colitis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2000 journal article

Helicobacter hepaticus does not induce or potentiate colitis in interleukin-10-deficient mice

INFECTION AND IMMUNITY, 68(9), 5107–5113.

By: L. Dieleman *, A. Arends*, S. Tonkonogy n, M. Goerres*, D. Craft*, W. Grenther n, R. Sellon n, E. Balish*, R. Sartor *

MeSH headings : Animals; CD4-Positive T-Lymphocytes / immunology; Colitis / etiology; Germ-Free Life; Helicobacter / pathogenicity; Interleukin-10 / deficiency; Interleukin-10 / physiology; Lymphocyte Activation; Mice; Mice, Inbred C57BL
TL;DR: It was found that IL-10−/− mice monoassociated with H. hepaticus for up to 16 weeks showed almost no histologic colitis or increased IL-12 production, and therefore is not required to induce colitis in genetically susceptible hosts. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1999 journal article

IL-2-deficient mice raised under germfree conditions develop delayed mild focal intestinal inflammation

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 276(6), G1461–G1472.

By: M. Schultz *, S. Tonkonogy n, R. Sellon n, C. Veltkamp*, V. Godfrey*, J. Kwon n, W. Grenther n, E. Balish*, I. Horak *, R. Sartor *

author keywords: interleukin-2-deficient mice; luminal flora; colitis; animal models
MeSH headings : Animals; Colitis / etiology; Colitis / pathology; Colon / metabolism; Digestive System / pathology; Gastritis / etiology; Gastritis / pathology; Germ-Free Life; Hepatitis, Animal / etiology; Immunoglobulins / biosynthesis; Interleukin-2 / deficiency; Interleukin-2 / genetics; Interleukin-2 / metabolism; Mice; Mice, Inbred C57BL; Mice, Knockout / genetics; Time Factors
TL;DR: In contrast to other genetically engineered rodents, IL-2 -/- mice develop mild focal gastrointestinal and active portal tract inflammation in the absence of viable bacteria. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

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