Cynthia J. Wolf
Works (5)
Updated: July 5th, 2023 16:01
2004 journal article
Interactive effects of vinclozolin and testosterone propionate on pregnancy and sexual differentiation of the male and female SD Rat
TOXICOLOGICAL SCIENCES, 78(1), 135–143.
author keywords: sexual differentiation; endocrine-disrupting compounds; cumulative risk; androgen; antiandrogen
MeSH headings : Abnormalities, Drug-Induced / epidemiology; Abnormalities, Drug-Induced / pathology; Androgen Antagonists / pharmacology; Androgen Antagonists / toxicity; Animals; Animals, Newborn; Birth Weight / drug effects; Body Weight / drug effects; Female; Fetal Viability / drug effects; Fetus / metabolism; Genitalia / drug effects; Genitalia / growth & development; Male; Organ Size / drug effects; Oxazoles / antagonists & inhibitors; Oxazoles / pharmacology; Oxazoles / toxicity; Pregnancy; Pregnancy, Animal / drug effects; Rats; Rats, Sprague-Dawley; Sex Characteristics; Sex Differentiation / drug effects; Sexual Maturation / drug effects; Teratogens / toxicity; Testosterone Propionate / antagonists & inhibitors; Testosterone Propionate / metabolism; Testosterone Propionate / pharmacology; Weight Gain / drug effects
TL;DR:
It is observed that the combination of V and TP, two chemicals with opposing endocrine action, antagonized one another during sexual differentiation, especially in the female offspring and induced cumulative effects on maternal and neonatal toxicity.
(via Semantic Scholar)
open access via academic.oup.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
6. Clean Water and Sanitation
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2002 journal article
Effects of prenatal testosterone propionate on the sexual development of male and female rats: A dose-response study
TOXICOLOGICAL SCIENCES, 65(1), 71–86.
author keywords: testosterone propionate; androgens; masculinization; prenatal exposure; sexual differentiation; anogenital distance; agenesis of the lower vagina; Sprague-Dawley rats
MeSH headings : Abnormalities, Drug-Induced / etiology; Anal Canal / abnormalities; Animals; Animals, Newborn; Dose-Response Relationship, Drug; Female; Genitalia, Female / abnormalities; Genitalia, Male / abnormalities; Gonadal Steroid Hormones / administration & dosage; Gonadal Steroid Hormones / physiology; Gonadal Steroid Hormones / toxicity; Male; Maternal Exposure / adverse effects; Nipples / abnormalities; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Testosterone / administration & dosage; Testosterone / physiology; Testosterone / toxicity; Toxicity Tests; Vagina / abnormalities
TL;DR:
Gestation administration of 0.5 and 1 mg TP masculinizes female offspring without greatly affecting pup viability or pregnancy of the dam, and this study provides a useful model for in utero testing of environmental androgens for their potential to induce developmental abnormalities.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2000 journal article
Characterization of the period of sensitivity of fetal male sexual development to vinclozolin
TOXICOLOGICAL SCIENCES, 55(1), 152–161.
author keywords: vinclozolin; antiandrogen; androgen receptor; male reproductive development; critical period; levator ani; hypospadias; anogenital distance
MeSH headings : Androgen Antagonists / toxicity; Animals; Embryonic and Fetal Development / drug effects; Female; Fertility / drug effects; Fungicides, Industrial / toxicity; Genitalia, Male / abnormalities; Genitalia, Male / drug effects; Genitalia, Male / embryology; Male; Organ Size / drug effects; Oxazoles / toxicity; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Long-Evans; Sexual Maturation / drug effects; Testis / abnormalities; Weight Gain / drug effects
TL;DR:
The data indicate that the reproductive system of the fetal male rat is most sensitive to antiandrogenic effects of vinclozolin, although effects are more severe and 100 % of male offspring are affected with administration of v inclozol from GD 14 through GD 19.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
1999 journal article
Antiandrogenic effects of prenatal vinclozolin exposure in the male rat: And investigation of possible involvement of EGF.
Biology of Reproduction, 60(1999), 138.
Source: NC State University Libraries
Added: August 6, 2018
1999 journal article
Environmental antiandrogens: The malformation pattern varies with the mechanism of antiandrogenic action.
Biology of Reproduction, 60(1999), 201.
Source: NC State University Libraries
Added: August 6, 2018
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