Karina F. Rodriguez

Works (9)

Updated: July 5th, 2023 16:00

2006 journal article

Identification of candidate mRNAs associated with gonadotropin-induced maturation of murine cumulus oocyte complexes using serial analysis of gene expression

PHYSIOLOGICAL GENOMICS, 27(3), 318–327.

By: K. Rodriguez n, L. Blomberg*, K. Zuelke*, J. Miles  n, J. Alexander n & C. Farin n

MeSH headings : Animals; Cell Culture Techniques; Cell Separation; Dichlororibofuranosylbenzimidazole / pharmacology; Female; Follicle Stimulating Hormone / metabolism; Gene Expression Profiling / methods; Meiosis / drug effects; Meiosis / genetics; Mice; Oocytes / drug effects; Oocytes / physiology; Ovary / cytology; RNA, Messenger / genetics; RNA, Messenger / metabolism; Transcription, Genetic / drug effects
TL;DR: The critical period of transcription required for GVBD occurred between 15 and 30 min after culture initiation, and 39 and 27 transcripts were identified as differentially expressed at the P < or = 0.01 and P </= 0.001 levels. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2006 journal article

The role of transcription in EGF- and FSH-mediated oocyte maturation in vitro

ANIMAL REPRODUCTION SCIENCE, 98(1-2), 97–112.

By: C. Farin n, K. Rodriguez*, J. Alexander n, J. Hockney n, J. Herrick * & S. Kennedy-Stoskopf n

author keywords: meiosis; FSH; EGF; oocyte maturation; gene transcription
MeSH headings : Animals; Cell Culture Techniques; Dichlororibofuranosylbenzimidazole / pharmacology; Epidermal Growth Factor / pharmacology; Female; Follicle Stimulating Hormone / pharmacology; Horses; Mammals; Mice; Mitosis; Oocytes / drug effects; Oocytes / physiology; Transcription, Genetic
TL;DR: Results presented support the conclusions that EGF-induced oocytes maturation does not require nascent gene transcription in both mice and domestic cats and FSH requires gene transcription to induce oocyte maturation in both species. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2005 journal article

Effects of embryo culture on angiogenesis and morphometry of bovine placentas during early gestation

BIOLOGY OF REPRODUCTION, 73(4), 663–671.

By: . Miles  n, C. Farin n, K. Rodriguez n, J. Alexander n & P. Farin n

author keywords: developmental biology; embryo; gene regulation; in vitro fertilization; placenta
MeSH headings : Animals; Blastocyst / physiology; Blood Vessels / anatomy & histology; Cattle; Coculture Techniques; Culture Media / pharmacology; Culture Media, Serum-Free / pharmacology; Embryo Culture Techniques; Embryo, Mammalian / anatomy & histology; Female; Fertilization in Vitro / methods; Gene Expression; Gene Expression Regulation, Developmental; Gestational Age; Neovascularization, Physiologic; PPAR gamma / genetics; PPAR gamma / metabolism; Placenta / anatomy & histology; Placenta / blood supply; Placenta / drug effects; Pregnancy; Vascular Endothelial Growth Factor A / genetics; Vascular Endothelial Growth Factor A / metabolism
TL;DR: Placentas from embryos produced in vitro using a semidefined culture system exhibited a greater degree of aberrant development of the placenta during early gestation than with placentas produced in vivo or in vivo using an undefined culture system. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2004 journal article

Angiogenesis and morphometry of bovine placentas in late gestation from embryos produced in vivo or in vitro

BIOLOGY OF REPRODUCTION, 71(6), 1919–1926.

By: . Miles  n, C. Farin n, K. Rodriguez n, J. Alexander n & P. Farin n

author keywords: developmental biology; embryo; gene regulation; in vitro fertilization; placenta
MeSH headings : Animals; Blood Vessels / anatomy & histology; Cattle; Chorionic Villi / anatomy & histology; Female; Fetal Weight; Gestational Age; Neovascularization, Physiologic; PPAR gamma / genetics; PPAR gamma / metabolism; Placenta / anatomy & histology; Placenta / blood supply; Pregnancy; RNA, Messenger / metabolism; Vascular Endothelial Growth Factor A / genetics; Vascular Endothelial Growth Factor A / metabolism
TL;DR: Findings are consistent with the concept that compensatory mechanisms exist in the vascular beds of placentas from bovine embryos produced in vitro. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2004 article

Gene transcription and regulation of oocyte maturation

REPRODUCTION FERTILITY AND DEVELOPMENT, Vol. 16, pp. 55–67.

By: K. Rodriguez n & C. Farin n

author keywords: amanitin; bovine; 5,6-dicholoro-1-beta-D-ribofuranosyl-benzimidazole; follicle-stimulating hormone; gonadotropins; meiosis; murine
TL;DR: By understanding the molecular mechanisms underlying gonadotropin-induced maturation, improvement in oocyte maturation technologies may be expected as procedures to manipulate specific factors involved in signalling for resumption of meiosis are identified. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2003 journal article

Developmental capacity of bovine cumulus oocyte complexes after transcriptional inhibition of germinal vesicle breakdown

THERIOGENOLOGY, 61(7-8), 1499–1511.

By: K. Rodriguez n & C. Farin n

author keywords: oocyte; meiosis; transcription; blastocyst; bovine
MeSH headings : Animals; Cattle / embryology; Cells, Cultured; Cleavage Stage, Ovum / physiology; Culture Techniques; Dichlororibofuranosylbenzimidazole / pharmacology; Embryonic and Fetal Development; Estradiol / administration & dosage; Female; Fertilization in Vitro / veterinary; Follicle Stimulating Hormone / administration & dosage; Kinetics; Meiosis / drug effects; Nucleic Acid Synthesis Inhibitors / pharmacology; Oocytes / drug effects; Oocytes / physiology; Ovarian Follicle / physiology; Transcription, Genetic / drug effects; Zygote / physiology
TL;DR: Bovine COC maintained in meiotic arrest for 20 h by culture in the presence of the transcriptional inhibitor DRB retained their capacity to develop to the blastocyst stage after fertilization in vitro. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2002 journal article

Development of skeletal muscle and expression of candidate genes in bovine fetuses from embryos produced in vivo or in vitro

BIOLOGY OF REPRODUCTION, 67(2), 401–408.

By: A. Crosier n, C. Farin n, K. Rodriguez n, P. Blondin n, J. Alexander n & P. Farin n

author keywords: conceptus; developmental biology; embryo; fetus; gene regulation; in vitro fertilization
MeSH headings : Animals; Blastocyst / physiology; Body Weight / physiology; Cattle; DNA Primers; Electrophoresis, Agar Gel; Embryo Transfer; Embryonic and Fetal Development / physiology; Female; Fertilization in Vitro; Fetus / metabolism; Gene Expression Regulation, Developmental / genetics; Glyceraldehyde-3-Phosphate Dehydrogenases / metabolism; In Vitro Techniques; Indicators and Reagents; Male; Muscle Fibers, Skeletal / physiology; Muscle Proteins / biosynthesis; Muscle Proteins / genetics; Muscle, Skeletal / anatomy & histology; Muscle, Skeletal / embryology; Pregnancy; RNA / biosynthesis; RNA / genetics; Reverse Transcriptase Polymerase Chain Reaction
TL;DR: In vitro production of embryos resulted in fetuses with altered development of skeletal muscle fibers, and myostatin was identified as the candidate gene whose expression may contribute to the observed changes in muscle development of these fetuses. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2002 journal article

Roles of gene transcription and PKA subtype activation in maturation of murine oocytes

Reproduction (Cambridge, England), 123(6), 799–806.

By: K. Rodriguez n, R. Petters n, A. Crosier n & C. Farin n

MeSH headings : Amanitins / pharmacology; Animals; Cells, Cultured; Chorionic Gonadotropin / pharmacology; Cyclic AMP-Dependent Protein Kinase Type II; Cyclic AMP-Dependent Protein Kinases / antagonists & inhibitors; Cyclic AMP-Dependent Protein Kinases / metabolism; Dichlororibofuranosylbenzimidazole / pharmacology; Enzyme Activation / physiology; Enzyme Inhibitors / pharmacology; Female; Follicle Stimulating Hormone / pharmacology; Isoenzymes / metabolism; Mice; Mice, Inbred Strains; Oogenesis / physiology; Transcription, Genetic / drug effects; Transcription, Genetic / physiology
TL;DR: Results indicate that, in cultured murine COCs, FSH binding to cumulus cells results in the activation of type II PKA, which, in turn, mediates a downstream transcriptional event required for the initiation of GVBD. (via Semantic Scholar)
Source: NC State University Libraries
Added: August 6, 2018

1999 journal article

Gonadotropin-induced germinal vesicle breakdown in the mouse requires gene transcription.

Biology of Reproduction, 60(1999), 214.

By: K. Rodriguez, R. Petters & C. Farin

Source: NC State University Libraries
Added: August 6, 2018

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