Susan C. D'Costa

Works (13)

Updated: July 5th, 2023 16:01

2019 journal article

Engineered Cartilage from Human Chondrocytes with Homozygous Knockout of Cell Cycle Inhibitor p21

TISSUE ENGINEERING PART A, 26(7-8), 441–449.

By: S. D'Costa*, M. Rich  n & B. Diekman n

author keywords: genome editing; CRISPR; regeneration; tissue engineering
MeSH headings : Blotting, Western; Chondrocytes / cytology; Chondrocytes / metabolism; Clustered Regularly Interspaced Short Palindromic Repeats / genetics; Cyclin-Dependent Kinase Inhibitor p21 / genetics; Cyclin-Dependent Kinase Inhibitor p21 / metabolism; Gene Editing; Glycosaminoglycans / metabolism; Humans; Immunohistochemistry; Polymerase Chain Reaction; Tissue Engineering / methods
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Source: Web Of Science
Added: December 9, 2019

2015 journal article

Early-life dietary spray-dried plasma influences immunological and intestinal injury responses to later-life<i>Salmonella</i><i>typhimurium</i>challenge

British Journal of Nutrition, 113(5), 783–793.

By: P. Boyer n, S. D'Costa n, L. Edwards n , M. Milloway n, E. Susick n, L. Borst n , S. Thakur n , J. Campbell ...

author keywords: Spray-dried plasma; Early-life nutrition; Salmonella typhimurium; Intestinal inflammation; Mucosal immunity; Intestinal permeability; Weaning
MeSH headings : Animals; Biomarkers / blood; Biomarkers / metabolism; Blood Proteins / administration & dosage; Blood Proteins / therapeutic use; Crosses, Genetic; Cytokines / blood; Cytokines / metabolism; Diet / adverse effects; Diet / veterinary; Energy Intake; Enterocolitis / immunology; Enterocolitis / microbiology; Enterocolitis / prevention & control; Enterocolitis / veterinary; Feces / microbiology; Female; Ileum / immunology; Ileum / metabolism; Ileum / microbiology; Ileum / pathology; Immunity, Mucosal; Immunotherapy / adverse effects; Immunotherapy / veterinary; Intestinal Mucosa / immunology; Intestinal Mucosa / metabolism; Intestinal Mucosa / microbiology; Intestinal Mucosa / pathology; Male; Salmonella Infections, Animal / immunology; Salmonella Infections, Animal / metabolism; Salmonella Infections, Animal / microbiology; Salmonella Infections, Animal / prevention & control; Salmonella typhimurium / growth & development; Salmonella typhimurium / immunology; Salmonella typhimurium / isolation & purification; Sus scrofa; Swine; Swine Diseases / immunology; Swine Diseases / metabolism; Swine Diseases / microbiology; Swine Diseases / prevention & control; Weaning; Weight Gain
TL;DR: Results indicate that inclusion of SDP in PW diets can have an influence on subsequent immunological and intestinal injury responses induced by later-life S. typhimurium challenge. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2013 journal article

Bone marrow-derived cells participate in the formation of normal and neoplastic lung stroma

Anticancer Research, 33(3), 831–836.

By: S. D'Costa, L. Borst  & Y. Kim

Source: NC State University Libraries
Added: August 6, 2018

2013 journal article

Evaluation of a side population of canine lymphoma cells using Hoechst 33342 dye

JOURNAL OF VETERINARY SCIENCE, 14(4), 481–486.

By: M. Kim *, S. D'Costa n, S. Suter n & Y. Kim *

author keywords: dog; flow cytometry; Hoechst 33342; lymphoma; side population
MeSH headings : Animals; Benzimidazoles / metabolism; Cell Line, Tumor; Dog Diseases / diagnosis; Dog Diseases / drug therapy; Dog Diseases / pathology; Dogs; Flow Cytometry / methods; Flow Cytometry / veterinary; Fluorescent Dyes / metabolism; Gene Expression Regulation, Developmental; Lymphoma / diagnosis; Lymphoma / drug therapy; Lymphoma / pathology; Lymphoma / veterinary; Neoplastic Stem Cells / drug effects; Neoplastic Stem Cells / metabolism; Neoplastic Stem Cells / pathology; Side-Population Cells / drug effects; Side-Population Cells / metabolism; Side-Population Cells / pathology
TL;DR: The present study was performed to explore the potential value of a side population (SP) assay for identifying and characterizing putative CSCs among canine lymphoma cells. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2011 journal article

Morphologic and Molecular Analysis of 39 Spontaneous Feline Pulmonary Carcinomas

VETERINARY PATHOLOGY, 49(6), 971–978.

By: . S. D'Costa, B. Yoon n, D. Kim*, A. Motsinger-Reif  n, M. Williams n  & Y. Kim n

author keywords: cat; lung cancer; immunohistochemistry; thyroid transcription factor-1; surfactant protein a; epidermal growth factor receptor; p53
MeSH headings : Adenocarcinoma / metabolism; Adenocarcinoma / pathology; Adenocarcinoma / veterinary; Adenocarcinoma, Bronchiolo-Alveolar / metabolism; Adenocarcinoma, Bronchiolo-Alveolar / pathology; Adenocarcinoma, Bronchiolo-Alveolar / veterinary; Animals; Biomarkers, Tumor / genetics; Biomarkers, Tumor / metabolism; Carcinoma, Adenosquamous / metabolism; Carcinoma, Adenosquamous / pathology; Carcinoma, Adenosquamous / veterinary; Cat Diseases / genetics; Cat Diseases / metabolism; Cat Diseases / pathology; Cats; DNA, Neoplasm / chemistry; DNA, Neoplasm / genetics; ErbB Receptors / genetics; ErbB Receptors / metabolism; Female; Immunohistochemistry / veterinary; Incidence; Lung Neoplasms / metabolism; Lung Neoplasms / pathology; Lung Neoplasms / veterinary; Male; Neoplasm Metastasis; North Carolina; Nuclear Proteins / genetics; Nuclear Proteins / metabolism; Pulmonary Surfactant-Associated Protein A / genetics; Pulmonary Surfactant-Associated Protein A / metabolism; Sequence Analysis, DNA / veterinary; Thyroid Nuclear Factor 1; Transcription Factors / genetics; Transcription Factors / metabolism; Tumor Suppressor Protein p53 / genetics; Tumor Suppressor Protein p53 / metabolism
TL;DR: Results indicate that primary lung carcinomas are rare but aggressive tumors in cats, thereby warranting further studies on molecular carcinogenesis. (via Semantic Scholar)
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Sources: Web Of Science, ORCID
Added: August 6, 2018

2010 journal article

Characterization of side population cells in human malignant mesothelioma cell lines

LUNG CANCER, 70(2), 146–151.

By: K. Kai n, S. D'Costa n, B. Yoon n, A. Brody n, R. Sills* & Y. Kim n

author keywords: Mesothelioma; Side population; Cancer stem cell; Hoechst 33342; Tumorigenicity; Flow cytometry
MeSH headings : Animals; Cell Line, Tumor; Cell Proliferation; Cell Separation; Cisplatin / pharmacology; Feasibility Studies; Flow Cytometry; Gene Expression Regulation, Developmental; Humans; Mesothelioma / diagnosis; Mesothelioma / drug therapy; Mesothelioma / pathology; Mice; Mice, SCID; Neoplasm Transplantation; Neoplastic Stem Cells / drug effects; Neoplastic Stem Cells / metabolism; Neoplastic Stem Cells / pathology; Side-Population Cells / drug effects; Side-Population Cells / metabolism; Side-Population Cells / pathology
TL;DR: The data indicated that SP assay may not be appropriate for enriching putative CSCs in HMM cell lines, and thus warrants the development of a novel tool for mesothelial CSC study. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Inhibition of the insulin-like growth factor 1 receptor pathway enhances the antitumor effect of cisplatin in human malignant mesothelioma cell lines

CANCER LETTERS, 278(1), 49–55.

By: K. Kai n, S. D'Costa n, R. Sills* & Y. Kim n

author keywords: Malignant mesothelioma; Insulin-like growth factor 1 receptor; AG1024; Cisplatin; Chemoresistance
MeSH headings : Antineoplastic Agents / therapeutic use; Apoptosis / drug effects; Cell Division / drug effects; Cell Line, Tumor / drug effects; Cisplatin / therapeutic use; Humans; Mesothelioma / drug therapy; Pleural Neoplasms / drug therapy; Receptor, IGF Type 1 / antagonists & inhibitors; Signal Transduction / drug effects; Tyrphostins / therapeutic use
TL;DR: This study supports the conjecture that inhibition of the IGF-1R pathway may be a useful target for reducing toxicity and alleviating chemoresistance to traditional anticancer drugs in HMM patients. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2005 journal article

Production of germline chimeric chickens following the administration of a busulfan emulsion

MOLECULAR REPRODUCTION AND DEVELOPMENT, 70(4), 438–444.

By: Y. Song  n, . S D'Costa, S. Pardue n & J. Petitte n 

author keywords: germline; chimera; busulfan; chicken
MeSH headings : Alkylating Agents / pharmacology; Animals; Busulfan / pharmacology; Chick Embryo; Chickens / genetics; Chimera / genetics; Female; Male; Ovum / drug effects; Spermatozoa / drug effects
TL;DR: Results demonstrated that the administration of a busulfan emulsion into the egg yolk of unincubated eggs improved the depletion of endogenous PGCs in the embryo and enhanced the efficiency of germline chimera production. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2004 patent

Methods for gamete production in birds

Washington, DC: U.S. Patent and Trademark Office.

By: S. Pardue, J. Petitte , S. D'Costa & Y. Song

Source: NC State University Libraries
Added: August 6, 2018

2001 review

Comparative development of avian primordial germ cells and production of germ line chimeras

[Review of ]. AVIAN AND POULTRY BIOLOGY REVIEWS, 12(4), 151–168.

By: . S D'Costa, S. Pardue* & J. Petitte* 

author keywords: primordial germ cells; embryo; chimeras; chick; turkey; quail; migration; transgenic
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2000 journal article

Expression and purification of biologically active recombinant quail stem cell factor in E-coli

CELL BIOLOGY INTERNATIONAL, 24(5), 311–317.

By: . S D'Costa, M. Kulik n & J. Petitte n 

author keywords: quail; stem cell factor; SCF; his-tagged; recombinant protein
MeSH headings : Animals; Biological Assay; Blotting, Western; Cell Survival / drug effects; Cells, Cultured; Chick Embryo; Chromatography, Affinity; Ciliary Neurotrophic Factor / pharmacology; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Escherichia coli / genetics; Escherichia coli / metabolism; Ganglia, Spinal / cytology; Ganglia, Spinal / drug effects; Neurons / cytology; Neurons / drug effects; Quail / genetics; Recombinant Fusion Proteins / biosynthesis; Recombinant Fusion Proteins / genetics; Recombinant Fusion Proteins / isolation & purification; Recombinant Fusion Proteins / pharmacology; Stem Cell Factor / biosynthesis; Stem Cell Factor / genetics; Stem Cell Factor / isolation & purification; Stem Cell Factor / pharmacology
TL;DR: The availability of quail SCF will be a valuable tool to further resolve the function of stem cell factor in birds as it improved neuronal survival and survival and resembled the soluble form of SCF. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2000 patent

Methods for gamete production in birds

Washington, DC: U.S. Patent and Trademark Office.

By: S. Pardue, J. Petitte  & S. D'Costa

Source: NC State University Libraries
Added: August 6, 2018

1999 journal article

Characterization of stage-specific embryonic antigen-1 (SSEA-1) expression during early development of the turkey embryo

International Journal of Developmental Biology, 43(4), 349–356.

By: S. D'Costa & J. Petitte 

Source: NC State University Libraries
Added: August 6, 2018

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