Works (37)
Updated: July 22nd, 2023 21:15
2016 journal article
Allergic inflammation is augmented via histamine H4 receptor activation: The role of natural killer cells in vitro and in vivo
JOURNAL OF DERMATOLOGICAL SCIENCE, 83(2), 106–115.
author keywords: Natural killer cells; Histamine H4 receptor; CCL17/TARC; Dermal dendritic cells; Allergic contact dermatitis
MeSH headings : Animals; Chemokine CCL17 / metabolism; Chemotaxis / drug effects; Coculture Techniques; Dendritic Cells / drug effects; Dendritic Cells / metabolism; Dermatitis, Atopic / immunology; Dermatitis, Atopic / metabolism; Disease Models, Animal; Female; Histamine / metabolism; Humans; Indoles / pharmacology; Killer Cells, Natural / drug effects; Killer Cells, Natural / metabolism; Mice; Mice, Inbred BALB C; Mice, Knockout; Ovalbumin; Piperazines / pharmacology; Pyrimidines / pharmacology; Receptors, G-Protein-Coupled / agonists; Receptors, G-Protein-Coupled / antagonists & inhibitors; Receptors, G-Protein-Coupled / genetics; Receptors, G-Protein-Coupled / metabolism; Receptors, Histamine / genetics; Receptors, Histamine / metabolism; Receptors, Histamine H4; Skin / cytology; Skin / drug effects; Skin / metabolism; Toluene 2,4-Diisocyanate / toxicity
TL;DR:
The H4R is identified as a new target controlling NK cell migration and NK cell-dendritic cell interaction in the skin during early allergic inflammation and is suggested to be beneficial in diseases like AD.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Canine epidermolysis bullosa acquisita: A retrospective study of 20 cases
Veterinary Dermatology, 26(6), 441-.
Source: NC State University Libraries
Added: August 6, 2018
2015 journal article
Expression patterns of superficial epidermal adhesion molecules in an experimental dog model of acute atopic dermatitis skin lesions
VETERINARY DERMATOLOGY, 26(1), 53-+.
Contributors: T. Olivry n & n
MeSH headings : Animals; Cell Adhesion Molecules / metabolism; Dermatitis, Atopic / metabolism; Dermatitis, Atopic / pathology; Dermatitis, Atopic / veterinary; Dog Diseases / metabolism; Dog Diseases / pathology; Dogs; Epidermis / metabolism; Epidermis / pathology; Fluorescent Antibody Technique, Indirect / veterinary; Patch Tests / veterinary; Transcriptome
TL;DR:
It is suggested that HDM allergens, via proteolytic digestion and/or because of induced allergic inflammation, affect the expression and possible function of corneodesmosomal and tight junction proteins.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2014 journal article
Serum autoantibody profiles of IgA, IgE and IgM in canine pemphigus foliaceus
VETERINARY DERMATOLOGY, 25(5), 471–E75.
Contributors: P. Bizikova n, T. Olivry n , L. Mamo n & n
MeSH headings : Animals; Autoantibodies / blood; Autoantibodies / immunology; Desmocollins / immunology; Desmoglein 1 / immunology; Dog Diseases / blood; Dog Diseases / immunology; Dogs; Fluorescent Antibody Technique, Indirect / veterinary; Immunoglobulin A / blood; Immunoglobulin A / immunology; Immunoglobulin E / blood; Immunoglobulin E / immunology; Immunoglobulin M / blood; Immunoglobulin M / immunology; Keratinocytes / immunology; Pemphigus / blood; Pemphigus / immunology; Pemphigus / veterinary
TL;DR:
It appears that canine PF is aetiologically and immunologically similar to that of the classic human PF, in which the IgG autoantibody response is also the predominant type.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2013 journal article
Cowhage can induce itch in the atopic dog
EXPERIMENTAL DERMATOLOGY, 22(6), 435–437.
Contributors: T. Olivry n , P. Bizikova n, J. Paps n, n, E. Lerner* & G. Yosipovitch *
author keywords: canine; dog; itch; model; pruritus
MeSH headings : Animals; Dermatitis, Atopic / etiology; Dermatitis, Atopic / physiopathology; Dogs; Hot Temperature; Inflammation; Mucuna / metabolism; Peptide Hydrolases / chemistry; Protein Denaturation; Pruritus / etiology; Pruritus / physiopathology; Random Allocation; Recombinant Proteins / chemistry; Skin / drug effects; Skin Tests / methods
TL;DR:
Cowhage spicules, protein‐rich extracts and mucunain can all inducePruritus and inflammation in dogs as in other species, but the inconsistency of provocation is currently a limitation of this challenge type for future studies of pruritus in dogs.
(via Semantic Scholar)
www.onlinelibrary.wiley.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2012 journal article
Deficient plakophilin-1 expression due to a mutation in PKP1 causes ectodermal dysplasia-skin fragility syndrome in Chesapeake Bay Retriever dogs
PLoS One, 7(2).
Source: NC State University Libraries
Added: August 6, 2018
2012 journal article
Validation of a novel epicutaneous delivery system for patch testing of house dust mite-hypersensitive dogs
Veterinary Dermatology, 23(6).
Source: NC State University Libraries
Added: August 6, 2018
2011 journal article
Metaflumizone-amitraz (Promeris)-associated pustular acantholytic dermatitis in 22 dogs: evidence suggests contact drug-triggered pemphigus foliaceus
VETERINARY DERMATOLOGY, 22(5), 436–448.
Contributors: U. Oberkirchner, K. Linder n, *, P. Bizikova* & T. Olivry n
MeSH headings : Administration, Topical; Animals; Apoptosis / drug effects; Apoptosis / physiology; Caspase 3 / metabolism; Dog Diseases / chemically induced; Dog Diseases / drug therapy; Dog Diseases / immunology; Dog Diseases / pathology; Dogs; Female; Immunosuppressive Agents / administration & dosage; Immunosuppressive Agents / therapeutic use; Insecticides / administration & dosage; Insecticides / adverse effects; Keratinocytes / enzymology; Male; Pemphigus / chemically induced; Pemphigus / drug therapy; Pemphigus / veterinary; Semicarbazones / administration & dosage; Semicarbazones / adverse effects; Skin / pathology; Toluidines / administration & dosage; Toluidines / adverse effects
TL;DR:
PD has the potential of triggering a variant of PF that resembles spontaneously occurring autoimmune PF at clinical, morphological, immunological and treatment outcome levels.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2011 journal article
Stratum corneum removal facilitates experimental sensitization to mite allergens in atopic dogs
VETERINARY DERMATOLOGY, 22(2), 188–196.
Contributors: T. Olivry n , J. Wofford n, J. Paps n & n
MeSH headings : Allergens / administration & dosage; Allergens / immunology; Animals; Antigens, Dermatophagoides / immunology; CD4-Positive T-Lymphocytes / metabolism; Dermatitis, Atopic / immunology; Dermatitis, Atopic / veterinary; Dermatophagoides farinae / immunology; Dog Diseases / immunology; Dogs; Epidermis / immunology; Female; Immunoglobulin E / blood; Interleukin-2 Receptor alpha Subunit / biosynthesis; Intradermal Tests; Ki-1 Antigen / biosynthesis; Lymphocyte Activation; Male; Pilot Projects
TL;DR:
Observations implicate a role of the SC as a barrier limiting sensitization to exogenous allergens in this experimental atopic dog model.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2010 journal article
Clinical and immunological heterogeneity of canine subepidermal blistering dermatoses with anti-laminin-332 (laminin-5) auto-antibodies
Veterinary Dermatology, 21(4), 345–357.
Source: NC State University Libraries
Added: August 6, 2018
2010 journal article
Usefulness of Collagen IV Immunostaining for Diagnosis of Canine Epidermolysis Bullosa Acquisita
VETERINARY PATHOLOGY, 47(3), 565–568.
Contributors: T. Olivry n & n
author keywords: auto-immunity; canine; dermatopathology; skin
MeSH headings : Animals; Collagen Type IV / analysis; Collagen Type IV / immunology; Dog Diseases / diagnosis; Dogs; Epidermolysis Bullosa Acquisita / diagnosis; Epidermolysis Bullosa Acquisita / veterinary; Immunohistochemistry / veterinary; Skin / chemistry; Skin / pathology
TL;DR:
Collagen IV immunostaining on paraffin-embedded skin biopsies as an aid to diagnose EBA in dogs offers an inexpensive means to help making a suggestive diagnosis of E BA in the absence of serological determination of the targeted autoantigen.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2009 journal article
Investigations on the nature and pathogenicity of circulating antikeratinocyte antibodies in dogs with pemphigus foliaceus
VETERINARY DERMATOLOGY, 20(1), 42–50.
MeSH headings : Animals; Animals, Newborn; Antibody Specificity; Blister / immunology; Dog Diseases / immunology; Dogs; Epidermis / metabolism; Immunization, Passive; Immunoglobulin G / blood; Keratinocytes / immunology; Mice; Pemphigus / blood; Pemphigus / immunology; Pemphigus / veterinary; Protein Binding
TL;DR:
It is suggested that antikeratinocyte IgG4 antibodies could be relevant to disease pathogenesis because canine PF or PV IgG appear to be pathogenic when transferred passively into mice, causing vesiculation at epidermal levels similar to those of the natural disease.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2008 journal article
Epicutaneous sensitization with Dermatophagoides farinae induces generalized allergic dermatitis and elevated mite-specific immunoglobulin E levels in a canine model of atopic dermatitis
CLINICAL AND EXPERIMENTAL ALLERGY, 38(4), 667–679.
Contributors: C. Pucheu-Haston n, H. Jackson n, T. Olivry n , n & B. Hammerberg n
author keywords: allergy; animal models; atopic dermatitis; atopy; Dermatophagoides farinae; dogs; skin (dermatology) immunology
MeSH headings : Animals; Dermatitis, Atopic / blood; Dermatitis, Atopic / immunology; Dermatitis, Atopic / pathology; Dermatophagoides farinae / immunology; Disease Models, Animal; Dogs; Female; Immunoglobulin E / blood; Immunoglobulin G / blood; Male; Pruritus / blood; Pruritus / immunology; Pruritus / pathology; Skin Tests
TL;DR:
Background Atopic dermatitis is a cutaneous hypersensitivity associated with elevated levels of antigen‐specific IgE, commonly to house dust mites (HDMs), and it remains controversial as to whether sensitization and clinical disease are induced by cutaneous exposure to HDM.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2008 journal article
Lack of detection of circulating skin-specific IgE autoantibodies in dogs with moderate or severe atopic dermatitis
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 122(1-2), 182–187.
Contributors: T. Olivry* , *, K. Pluchino, K. Porter* & B. Hammerberg*
author keywords: allergy; atopy; autoimmunity; canine; IgE; skin
MeSH headings : Animals; Autoantibodies / blood; Dermatitis, Atopic / veterinary; Dog Diseases / immunology; Dogs; Female; Fluorescent Antibody Technique, Indirect; Immunoblotting; Immunoglobulin E / blood; Male; Skin / immunology
TL;DR:
Either IgE autoreactivity is not associated with moderate to severe AD in dogs, or the methods employed herein were not sensitive enough to permit IgE autoantibody detection.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2007 article
Regional parasite density in the skin of dogs with symptomatic canine leishmaniosis
Saridomichelakis, M. N., Koutinas, A. F., Olivry, T., Dunston, S. M., Farmaki, R., Koutinas, C. K., & Petanides, T. (2007, August). VETERINARY DERMATOLOGY, Vol. 18, pp. 227–233.
Contributors: M. Saridomichelakis *, A. Koutinas*, T. Olivry n , n, R. Farmaki *, C. Koutinas*, T. Petanides
MeSH headings : Animals; Case-Control Studies; Dog Diseases / parasitology; Dog Diseases / pathology; Dogs; Female; Leishmania / isolation & purification; Leishmania / pathogenicity; Leishmaniasis, Cutaneous / parasitology; Leishmaniasis, Cutaneous / veterinary; Male; Severity of Illness Index
TL;DR:
No selective accumulation of the parasite in the muzzle that would favour its transmission to sandflies occurred, and the mechanical stress imposed on the footpads was not associated with increased parasitic density, or with inflammatory infiltrate.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2006 journal article
Desmoglein-1 is a minor autoantigen in dogs with pemphigus foliaceus
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 110(3-4), 245–255.
Contributors: T. Olivry n , A. LaVoy n, n, R. Brown n, E. Lennon n, S. Warren *, P. Prisayanh*, E. Müller*, M. Suter*, G. Dean n
author keywords: autoimmunity; blistering; canine; cadherin; desmosome; skin
MeSH headings : Animals; Autoantibodies / immunology; Autoantigens / immunology; Calcium / metabolism; Cell Line; Desmoglein 1 / immunology; Dog Diseases / immunology; Dogs; Glycosylation; Humans; Pemphigus / immunology; Pemphigus / veterinary
TL;DR:
These studies establish canine dsg1 as a minor autoantigen for canine PF, and antigenic epitopes appear to be conformation- and glycosylation-dependent.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2006 journal article
Patch testing of experimentally sensitized beagle dogs: development of a model for skin lesions of atopic dermatitis
VETERINARY DERMATOLOGY, 17(2), 95–102.
Contributors: T. Olivry n , K. Deangelo n, n, K. Clarke* & C. McCall *
MeSH headings : Animals; Dermatitis, Atopic / immunology; Dermatitis, Atopic / veterinary; Dermatophagoides farinae / immunology; Disease Models, Animal; Dog Diseases / immunology; Dog Diseases / pathology; Dogs; Female; Humans; Immunohistochemistry / veterinary; Male; Patch Tests / veterinary; Receptors, IgE / analysis; Severity of Illness Index
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2005 journal article
Clinical, histopathological and immunological characteristics of exfoliative cutaneous lupus erythematosus in 25 German short-haired pointers
VETERINARY DERMATOLOGY, 16(4), 239–252.
Contributors: S. Bryden*, S. White *, n, A. Burrows* & T. Olivry n
MeSH headings : Animals; Australia / epidemiology; Dog Diseases / drug therapy; Dog Diseases / epidemiology; Dog Diseases / genetics; Dog Diseases / immunology; Dog Diseases / pathology; Dogs; Female; Genetic Predisposition to Disease; Immunoglobulin G / immunology; Immunohistochemistry / veterinary; Lupus Erythematosus, Cutaneous / immunology; Lupus Erythematosus, Cutaneous / veterinary; Male; Pedigree; United Kingdom / epidemiology; United States / epidemiology
TL;DR:
The existence of a cellular and humoral immune response directed against the epidermal basement membrane of dogs with exfoliative cutaneous lupus erythematosus is demonstrated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2004 article
Immunopathology of vesicular cutaneous lupus erythematosus in the rough collie and Shetland sheepdog: a canine homologue of subacute cutaneous lupus erythematosus in humans
Jackson, H. A., Olivry, T., Berget, F., Dunston, S. M., Bonnefont, C., & Chabanne, L. (2004, August). VETERINARY DERMATOLOGY, Vol. 15, pp. 230–239.
Contributors: H. Jackson n, T. Olivry n , F. Berget*, n, C. Bonnefont* & L. Chabanne*
author keywords: antinuclear antibodies; autoimmunity; canine; integument; lupus erythematosus; skin; subacute cutaneous lupus erythematosus
MeSH headings : Animals; Antibodies, Antinuclear / immunology; Dog Diseases / immunology; Dogs; Enzyme-Linked Immunosorbent Assay / veterinary; Female; Humans; Immunophenotyping / veterinary; In Situ Nick-End Labeling / veterinary; Lupus Erythematosus, Cutaneous / immunology; Lupus Erythematosus, Cutaneous / veterinary; Male; Pedigree; Species Specificity
TL;DR:
Results of these studies provide evidence supporting the hypothesis that canine VCLE is an immunological homologue of subacute cutaneous lupus erythematosus in humans.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2003 journal article
A natural canine homologue of alopecia areata in humans
BRITISH JOURNAL OF DERMATOLOGY, 149(5), 938–950.
Contributors: D. Tobin n, S. Gardner n, P. Luther n, n, N. Lindsey n & T. Olivry n
author keywords: alopecia areata; autoimmunity; canine; dog; folliculitis; hair loss
MeSH headings : Alopecia Areata / immunology; Alopecia Areata / pathology; Alopecia Areata / veterinary; Animals; Autoantibodies / blood; Autoimmune Diseases / immunology; Autoimmune Diseases / pathology; Autoimmune Diseases / veterinary; Disease Models, Animal; Dog Diseases / immunology; Dog Diseases / pathology; Dogs; Female; Fluorescent Antibody Technique, Direct; Fluorescent Antibody Technique, Indirect; Hair Follicle / immunology; Humans; Immunization, Passive; Immunoglobulin G / blood; Immunophenotyping; Male; Mice; Mice, Inbred C57BL
TL;DR:
Alopecia areata is suspected to be an autoimmune disease directed preferentially against hair follicles affecting both humans and various mammalian species and it is not known whether dogs with AA could be useful as an outbred homologue of this disease in humans.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2003 journal article
A randomized controlled trial of misoprostol monotherapy for canine atopic dermatitis: effects on dermal cellularity and cutaneous tumour necrosis factor-alpha
VETERINARY DERMATOLOGY, 14(1), 37–46.
Contributors: T. Olivry n , n, C. Rivierre n, H. Jackson n, K. Murphy n, E. Peters n, G. Dean n
author keywords: allergy; atopic dermatitis; atopy; canine; misoprostol; randomized controlled trial; tumour necrosis factor alpha
MeSH headings : Administration, Oral; Animals; Dermatitis, Atopic / drug therapy; Dermatitis, Atopic / veterinary; Dermatologic Agents / administration & dosage; Dermatologic Agents / pharmacology; Dermatologic Agents / therapeutic use; Dog Diseases / drug therapy; Dog Diseases / pathology; Dogs; Double-Blind Method; Female; Fluorescent Antibody Technique, Indirect / veterinary; Male; Misoprostol / administration & dosage; Misoprostol / pharmacology; Misoprostol / therapeutic use; RNA, Messenger / drug effects; RNA, Messenger / metabolism; Treatment Outcome; Tumor Necrosis Factor-alpha / drug effects; Tumor Necrosis Factor-alpha / metabolism
TL;DR:
The modest efficacy of misoprostol for treatment of canine AD is confirmed and its mild anti-allergic effects are suggested to be associated with either inhibition of inflammatory cell emigration or TNFalpha production.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2003 journal article
Desmoglein-3 is a target autoantigen in spontaneous canine pemphigus vulgaris
EXPERIMENTAL DERMATOLOGY, 12(2), 198–203.
Contributors: T. Olivry n , S. Joubeh*, n, T. Nishiyama* & R. Ghohestani*
author keywords: autoimmunity; cadherin; canine; desmosomes; desmoglein-3; dog; pemphigus
MeSH headings : Animals; Autoantigens / isolation & purification; Cadherins / immunology; Cadherins / isolation & purification; Cells, Cultured; Desmoglein 3; Dog Diseases / immunology; Dogs; Female; Fluorescent Antibody Technique, Direct; Fluorescent Antibody Technique, Indirect; Immunoblotting; Keratinocytes / immunology; Male; Pemphigus / immunology; Pemphigus / veterinary
TL;DR:
Evidence is provided that the canine desmoglein‐3 homologue is a major autoantigen in dogs with PV, which establishes spontaneous canine PV as a natural model for research on pathogenesis, etiology and novel therapeutic approaches for this disease of humans.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2003 journal article
Intraocular extramedullary plasmacytoma in a cat
VETERINARY OPHTHALMOLOGY, 6(2), 177–181.
Contributors: T. Michau n, D. Proulx n, S. Rushton n, T. Olivry n , n, B. Gilger n , M. Davidson n
author keywords: extramedullary; feline; iris; neoplasia; plasmacytoma
MeSH headings : Animals; Antineoplastic Agents / therapeutic use; Blindness / etiology; Blindness / veterinary; Cat Diseases / diagnosis; Cat Diseases / drug therapy; Cat Diseases / pathology; Cats; Drug Therapy, Combination; Eye Injuries / complications; Eye Injuries / veterinary; Eye Neoplasms / complications; Eye Neoplasms / diagnosis; Eye Neoplasms / veterinary; Lymphatic Metastasis; Male; Melphalan / therapeutic use; Orbit Evisceration / veterinary; Plasmacytoma / complications; Plasmacytoma / diagnosis; Plasmacytoma / veterinary; Prednisone / therapeutic use
TL;DR:
An 8-year-old, castrated male Domestic Short-haired cat was referred for evaluation of a possible intraocular neoplasm following previous ocular trauma and enucleation revealed neoplastic proliferation of plasma cells in the iris and lymph node.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2003 journal article
Isotype determination of circulating autoantibodies in canine autoimmune subepidermal blistering dermatoses
VETERINARY DERMATOLOGY, 14(1), 23–30.
Contributors: C. Favrot *, n, M. Paradis * & T. Olivry n
author keywords: animal model; autoantibody; autoimmunity; epidermal basement membrane; epidermolysis bullosa acquisita; immunoglobulin subclass; isotype; pemphigoid
MeSH headings : Animals; Autoantibodies / blood; Autoimmune Diseases / immunology; Autoimmune Diseases / veterinary; Dog Diseases / blood; Dog Diseases / immunology; Dogs; Female; Fluorescent Antibody Technique, Indirect / veterinary; Immunoglobulin Isotypes / blood; Male; Skin Diseases, Vesiculobullous / immunology; Skin Diseases, Vesiculobullous / veterinary
TL;DR:
The predominance of IgG1, IgG4 and IgE autoantibody isotypes in dogs with AISBD is very similar to the situation found in humans with the homologous diseases.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2002 journal article
Effect of substrate selection on indirect immunofluorescence testing of canine autoimmune subepidermal blistering diseases
Canadian Journal of Veterinary Research, 66(1), 26–30.
Source: NC State University Libraries
Added: August 6, 2018
2002 journal article
Laminin-5 is targeted by autoantibodies in feline mucous membrane (cicatricial) pemphigoid
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 88(3-4), 123–129.
Contributors: T. Olivry n , n, G. Zhang* & R. Ghohestani*
author keywords: autoimmunity; basement membrane zone; cicatricial pemphigoid; feline; laminin-5
MeSH headings : Animals; Autoantibodies / immunology; Basement Membrane / immunology; Cat Diseases / immunology; Cats / immunology; Cell Adhesion Molecules / immunology; Immunoblotting; Immunoglobulin A / immunology; Immunoglobulin G / immunology; Male; Microscopy, Fluorescence; Pemphigoid, Benign Mucous Membrane / immunology; Pemphigoid, Benign Mucous Membrane / veterinary
TL;DR:
Observations identify laminin-5 as one of the antigens recognized by circulating autoantibodies in this feline homologue of MMP in humans and dogs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2001 journal article
A spontaneous canine model of mucous membrane (cicatricial) pemphigoid, an autoimmune blistering disease affecting mucosae and mucocutaneous junctions
JOURNAL OF AUTOIMMUNITY, 16(4), 411–421.
Contributors: T. Olivry n , n, M. Schachter*, L. Xu*, N. Nguyen, M. Marinkovich *, L. Chan*
author keywords: basement membrane; cicatricial; dog; skin
MeSH headings : Animals; Autoantigens / immunology; Autoimmune Diseases / immunology; Autoimmune Diseases / pathology; Collagen / immunology; Disease Models, Animal; Dogs; Enzyme-Linked Immunosorbent Assay / methods; Fluorescent Antibody Technique, Direct; Fluorescent Antibody Technique, Indirect; Immunoblotting / methods; Mucous Membrane / immunology; Mucous Membrane / pathology; Pemphigoid, Benign Mucous Membrane / immunology; Pemphigoid, Benign Mucous Membrane / pathology; Peptides / immunology; Prospective Studies; Retrospective Studies
TL;DR:
Canine MMP, like its human counterpart, exhibits distinctive clinical signs and histopathological lesions, yet circulating autoantibodies target different antigenic epitopes, which could prove useful for studies on the pathogenesis or therapy of this human disease.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2001 journal article
Characterization of the inflammatory infiltrate during IgE-mediated late phase reactions in the skin of normal and atopic dogs
VETERINARY DERMATOLOGY, 12(1), 49–58.
Contributors: T. Olivry n , n, K. Murphy n & P. Moore *
author keywords: allergy; atopic dermatitis; dog; late-phase reaction; skin
MeSH headings : Allergens; Animals; Case-Control Studies; Dermatitis, Atopic / immunology; Dermatitis, Atopic / veterinary; Dog Diseases / immunology; Dogs; Immunoglobulin E / immunology; Immunohistochemistry / veterinary; Leukocytes; Mites
TL;DR:
Because IgE-mediated late-phase reactions resemble spontaneous atopic canine skin lesions, both at macroscopic and microscopic levels, it is proposed the use of similar challenges to study the anti-inflammatory effects of anti-allergic drugs in a pre-clinical setting.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2001 journal article
Electron microscopic observations of stratum corneum intercellular lipids in normal and atopic dogs
VETERINARY PATHOLOGY, 38(6), 720–723.
Contributors: A. Inman*, T. Olivry* , *, N. Monteiro-Riviere* & H. Gatto
author keywords: barrier defect; canine atopic dermatitis; dogs; lipid lamellae; ruthenium tetroxide
MeSH headings : Animals; Biopsy / veterinary; Dermatitis, Atopic / metabolism; Dermatitis, Atopic / pathology; Dermatitis, Atopic / veterinary; Dog Diseases / metabolism; Dog Diseases / pathology; Dogs; Female; Fixatives / chemistry; Lipid Metabolism; Male; Microscopy, Electron / veterinary; Pilot Projects; Ruthenium Compounds / chemistry; Skin / metabolism; Skin / pathology; Skin / ultrastructure
TL;DR:
Preliminary observations suggest that the epidermal lipid barrier is defective in atopic canine skin and should be corrected with nutritional and/or pharmacologic intervention.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2000 journal article
A spontaneously arising porcine model of bullous pemphigoid
ARCHIVES OF DERMATOLOGICAL RESEARCH, 292(1), 37–45.
author keywords: basement membrane zone; bullous pemphigoid; pig
MeSH headings : Amino Acid Sequence; Animals; Autoantigens / analysis; Carrier Proteins; Collagen; Cytoskeletal Proteins; Disease Models, Animal; Dystonin; Enzyme-Linked Immunosorbent Assay; Epitopes / analysis; Fluorescent Antibody Technique; Immunoblotting; Immunosorbent Techniques; Microscopy, Electron; Microscopy, Fluorescence; Microscopy, Immunoelectron; Molecular Sequence Data; Nerve Tissue Proteins; Non-Fibrillar Collagens; Pemphigoid, Bullous / immunology; Pemphigoid, Bullous / metabolism; Pemphigoid, Bullous / pathology; Skin / chemistry; Skin / pathology; Skin / ultrastructure; Swine; Swine, Miniature
TL;DR:
This novel porcine acquired blistering dermatosis could be proposed as a valuable model to conduct immunomechanistic studies on the natural progression of BP, correlation of autoreactive T cells or autoantibodies with disease activity, and the role of eosinophils in the blistering process, as these diseases cannot be modeled easily in human patients or in murine passive transfer models.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2000 journal article
Autoantibodies against the processed ectodomain of collagen XVII (BPAG2, BP180) define a canine homologue of linear IgA disease of humans
VETERINARY PATHOLOGY, 37(4), 302–309.
author keywords: autoimmunity; BP180; BPAG2; collagen XVII; dogs; epidermal basement membrane; LAD-1; linear IgA bullous disease; skin
MeSH headings : Animals; Autoantibodies / analysis; Autoantigens / immunology; Carrier Proteins; Cell Line; Collagen / immunology; Cytoskeletal Proteins; Dog Diseases / immunology; Dogs; Dystonin; Fluorescent Antibody Technique, Direct / veterinary; Humans; Immunoglobulin A / analysis; Immunoglobulin G / analysis; Nerve Tissue Proteins; Non-Fibrillar Collagens; Skin Diseases, Vesiculobullous / immunology; Skin Diseases, Vesiculobullous / veterinary
TL;DR:
The present study establishes unequivocally the existence of a naturally occurring canine model of LAD of humans, and an immunologic homologue of L AD in humans was identified in two dogs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2000 journal article
Effects of a 1 percent hydrocortisone conditioner on the prevention of immediate and late-phase reactions in canine skin
Veterinary Record, 147(26), 739–742.
Source: NC State University Libraries
Added: August 6, 2018
2000 journal article
Equine bullous pemphigoid IgG autoantibodies target linear epitopes in the NC16A ectodomain of collagen XVII (BP180, BPAG2)
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 73(1), 45–52.
Contributors: T. Olivry* , A. Borrillo, L. Xu, *, N. Slovis, V. Affolter, T. Demanuelle, L. Chan
author keywords: autoimmunity; basement membrane zone; bullous pemphigoid; horse
MeSH headings : Animals; Autoantibodies / analysis; Autoantibodies / immunology; Autoantigens / immunology; Carrier Proteins; Collagen; Cytoskeletal Proteins; Dystonin; Enzyme-Linked Immunosorbent Assay; Epitopes; Horse Diseases / immunology; Horses; Immunoblotting; Immunoglobulin G / analysis; Immunoglobulin G / immunology; Microscopy, Fluorescence; Nerve Tissue Proteins; Non-Fibrillar Collagens; Pemphigoid, Bullous / immunology; Pemphigoid, Bullous / veterinary
TL;DR:
Equine BP could be proposed, therefore, as another spontaneous model of this most common basement membrane autoimmune dermatosis of humans.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2000 journal article
Novel localised variant of canine epidermolysis bullosa acquisita
VETERINARY RECORD, 146(7), 193–194.
MeSH headings : Animals; Dog Diseases / immunology; Dog Diseases / pathology; Dogs; Enzyme-Linked Immunosorbent Assay; Epidermolysis Bullosa Acquisita / immunology; Epidermolysis Bullosa Acquisita / pathology; Epidermolysis Bullosa Acquisita / veterinary; Immunoglobulin G / analysis; Male; Skin Diseases / immunology; Skin Diseases / pathology; Skin Diseases / veterinary
TL;DR:
It is conduded that ultrasonography is useful in the evaluation of chronic joint disease in sheep, and may be valuable in assessing the prognosis for sheep with chronic arthritis/synovitis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1999 journal article
Bullous systemic lupus erythematosus (type I) in a dog
VETERINARY RECORD, 145(6), 165–169.
MeSH headings : Animals; Autoantibodies / analysis; Collagen / immunology; Dapsone / therapeutic use; Diagnosis, Differential; Dog Diseases / diagnosis; Dog Diseases / drug therapy; Dog Diseases / immunology; Dogs; Drug Therapy, Combination; Enzyme-Linked Immunosorbent Assay / veterinary; Fluorescent Antibody Technique, Indirect / veterinary; Lupus Erythematosus, Systemic / diagnosis; Lupus Erythematosus, Systemic / drug therapy; Lupus Erythematosus, Systemic / immunology; Lupus Erythematosus, Systemic / veterinary; Male; Prednisone / therapeutic use; Skin / metabolism; Skin / pathology; Skin Diseases, Vesiculobullous / diagnosis; Skin Diseases, Vesiculobullous / drug therapy; Skin Diseases, Vesiculobullous / immunology; Skin Diseases, Vesiculobullous / veterinary
TL;DR:
Anti-collagen Vil type l-BSLE needs to be considered as a possible differential diagnosis for canine autoimmune subepidermal blistering diseases.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
1999 journal article
Novel feline autoimmune blistering disease resembling bullous pemphigoid in humans: IgG autoantibodies target the NC16A ectodomain of type XVII collagen (BP180/BPAG2)
VETERINARY PATHOLOGY, 36(4), 328–335.
author keywords: autoimmunity; BP180; BPAG2; cats; collagen XVII; epidermal basement membrane; pemphigoid; skin
MeSH headings : Animals; Autoantibodies / isolation & purification; Basement Membrane / immunology; Cat Diseases / immunology; Cat Diseases / pathology; Cats; Collagen / immunology; Enzyme-Linked Immunosorbent Assay; Immunoglobulin G / blood; Immunoglobulin G / immunology; Male; Pemphigoid, Bullous / immunology; Pemphigoid, Bullous / pathology; Pemphigoid, Bullous / veterinary
TL;DR:
Feline BP can be considered a clinical, histopathologic, and immunologic homologue of bullous pemphigoid in humans and dogs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1999 journal article
Reduced anchoring fibril formation and collagen VII immunoreactivity in feline dystrophic epidermolysis bullosa
VETERINARY PATHOLOGY, 36(6), 616–618.
author keywords: anchoring fibrils; cats; collagen VII; dystrophic epidermolysis bullosa; epidermal basement membrane; skin
MeSH headings : Animals; Antibodies, Monoclonal; Biopsy / veterinary; Cat Diseases / immunology; Cat Diseases / pathology; Cats; Collagen / analysis; Collagen / immunology; Epidermolysis Bullosa Dystrophica / immunology; Epidermolysis Bullosa Dystrophica / pathology; Epidermolysis Bullosa Dystrophica / veterinary; Epitopes; Female; Immunohistochemistry; Microscopy, Electron / veterinary; Mouth Mucosa / immunology; Mouth Mucosa / pathology; Skin / chemistry; Skin / immunology; Skin / pathology
TL;DR:
Dystrophic epidermolysis bullosa was diagnosed in a cat with juvenile-onset epithelial sloughing of the oral mucosa, footpads, and haired skin and the encoding gene, COL7A1, could be mutated in this case.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
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