Maria R. Blanton

Works (1)

Updated: July 5th, 2023 16:04

1997 journal article

Genetically engineered large animal model for studying cone photoreceptor survival and degeneration in retinitis pigmentosa

NATURE BIOTECHNOLOGY, 15(10), 965–970.

By: R. Petters n, C. Alexander n, K. Wells n, E. Collins n, . Sommer n, M. Blanton n, G. Rojas n, Y. Hao* ...

author keywords: transgenic swine; retinal degeneration; rhodopsin mutation; night blindness; eye disease
MeSH headings : Animals; Animals, Genetically Modified; Blotting, Southern; Disease Models, Animal; Electroretinography; Embryo Transfer; Gene Expression Regulation / genetics; Genetic Engineering; Microscopy, Electron; Molecular Sequence Data; Phenotype; Polymerase Chain Reaction; Retina / pathology; Retina / physiopathology; Retina / ultrastructure; Retinal Cone Photoreceptor Cells / physiopathology; Retinal Cone Photoreceptor Cells / ultrastructure; Retinal Degeneration / physiopathology; Retinitis Pigmentosa / genetics; Retinitis Pigmentosa / physiopathology; Rhodopsin / chemistry; Rhodopsin / genetics; Swine / embryology; Swine / genetics; Transgenes
TL;DR: These transgenic pigs that express a mutated rhodopsin gene will provide a large animal model for study of the protracted phase of cone degeneration found in RP and for preclinical treatment trials. (via Semantic Scholar)
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Added: August 6, 2018

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