Patricia A. Routh

Works (13)

Updated: July 18th, 2023 21:18

2017 journal article

Evaluation of a 2-aminoimidazole variant as adjuvant treatment for dermal bacterial infections

Drug Design Development and Therapy, 11, 153–162.

By: G. Draughn, C. Allen, P. Routh, M. Stone, K. Kirker, A. Boegli, R. Schuchman, K. Linder ...

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

Pharmacokinetics of C-14-ortho-phenylphenol following intravenous administration in pigs

JOURNAL OF APPLIED TOXICOLOGY, 37(4), 508–512.

By: E. Nixon n , J. Brooks n, P. Routh n, J. Chittenden * & R. Baynes n 

author keywords: pharmacokinetics; ortho-phenylphenol; intravenous dose; pig; biocide
MeSH headings : Administration, Intravenous; Animals; Area Under Curve; Biphenyl Compounds / administration & dosage; Biphenyl Compounds / pharmacokinetics; Disinfectants / pharmacokinetics; Feces / chemistry; Half-Life; Male; Sus scrofa; Swine; Tissue Distribution
TL;DR: Comparisons with other species suggest that 14C‐OPP clearance in pigs (2.48 ml h–1 kg–1) is less than that in humans and rats and that the kidneys play a crucial role in clearance with a large percentage of the dose being found in the urine. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2014 journal article

The Haemophilus ducreyi trimeric autotransporter adhesin DsrA protects against an experimental infection in the swine model of chancroid

VACCINE, 32(30), 3752–3758.

By: W. Fusco *, N. Choudhary*, P. Routh n, M. Ventevogel*, V. Smith *, G. Koch*, G. Almond n , P. Orndorff n, G. Sempowski *, I. Leduc*

author keywords: Haemophilus ducreyi; Trimeric autotransporter adhesin; DsrA; Active protection
MeSH headings : Adhesins, Bacterial / immunology; Adjuvants, Immunologic / administration & dosage; Animals; Antibodies, Bacterial / blood; Bacterial Vaccines / immunology; Chancroid / prevention & control; Disease Models, Animal; Fibrinogen / metabolism; Haemophilus ducreyi; Immune Sera / immunology; Immunity, Humoral; Immunoglobulin G / blood; Recombinant Proteins / immunology; Sus scrofa
TL;DR: Overall, immunization with the passenger domain of the trimeric autotransporter adhesin DsrA accelerated clearance of H. ducreyi in experimental lesions, possibly by interfering with fibrinogen binding. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 journal article

The effect of breed and sex on sulfamethazine, enrofloxacin, fenbendazole and flunixin meglumine pharmacokinetic parameters in swine

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 37(6), 531–541.

By: J. Howard  n, R. Baynes n , J. Brooks n, J. Yeatts n, B. Bellis n, M. Ashwell  n, P. Routh n, A. O'Nan n, C. Maltecca n 

Contributors: J. Howard  n, R. Baynes n , J. Brooks n, J. Yeatts n, B. Bellis n, M. Ashwell  n, P. Routh n, . A.T. O'Nan n, C. Maltecca n 

MeSH headings : Animals; Anti-Infective Agents / blood; Anti-Infective Agents / pharmacokinetics; Anti-Inflammatory Agents, Non-Steroidal / blood; Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics; Antinematodal Agents / blood; Antinematodal Agents / pharmacokinetics; Benzimidazoles / blood; Ciprofloxacin / blood; Clonixin / analogs & derivatives; Clonixin / blood; Clonixin / pharmacokinetics; Enrofloxacin; Female; Fenbendazole / blood; Fenbendazole / pharmacokinetics; Fluoroquinolones / blood; Fluoroquinolones / pharmacokinetics; Male; Sex Factors; Species Specificity; Sulfamethazine / analogs & derivatives; Sulfamethazine / blood; Sulfamethazine / pharmacokinetics; Swine / metabolism
TL;DR: Whether drug clearance differs across genetic backgrounds and sex for sulfamethazine, enrofloxacin, fenbendazole and flunixin meglumine is determined to determine the degree of additive genetic variation utilizing a larger population. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2011 journal article

Passive Immunization with a Polyclonal Antiserum to the Hemoglobin Receptor of Haemophilus ducreyi Confers Protection against a Homologous Challenge in the Experimental Swine Model of Chancroid

INFECTION AND IMMUNITY, 79(8), 3168–3177.

By: I. Leduc*, W. Fusco *, N. Choudhary*, P. Routh n, D. Cholon *, M. Hobbs*, G. Almond n , P. Orndorff n, C. Elkins *

MeSH headings : Animals; Antibodies, Bacterial / administration & dosage; Antibodies, Bacterial / immunology; Bacterial Proteins / immunology; Carrier Proteins / immunology; Chancroid / immunology; Chancroid / pathology; Chancroid / prevention & control; Disease Models, Animal; Ear / pathology; Haemophilus ducreyi / immunology; Haemophilus ducreyi / pathogenicity; Histocytochemistry; Immune Sera / administration & dosage; Immune Sera / immunology; Immunization, Passive / methods; Microbial Viability; Microscopy; Receptors, Cell Surface / immunology; Swine; Swine Diseases / immunology; Swine Diseases / prevention & control
TL;DR: Data suggest that the humoral immune response to the HgbA vaccine is protective against an H. ducreyi infection, possibly by preventing acquisition of the essential nutrient heme. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2010 journal article

Immunization with the Haemophilus ducreyi Hemoglobin Receptor HgbA with Adjuvant Monophosphoryl Lipid A Protects Swine from a Homologous but Not a Heterologous Challenge

INFECTION AND IMMUNITY, 78(9), 3763–3772.

By: W. Fusco *, G. Afonina*, I. Nepluev*, D. Cholon *, N. Choudhary*, P. Routh n, G. Almond n , P. Orndorff n ...

MeSH headings : Adjuvants, Immunologic / administration & dosage; Animals; Antibodies, Bacterial / blood; Bacterial Proteins / genetics; Bacterial Proteins / immunology; Bacterial Vaccines / immunology; Carrier Proteins / genetics; Carrier Proteins / immunology; Chancroid / prevention & control; Enzyme-Linked Immunosorbent Assay; Haemophilus ducreyi / immunology; Immune Sera / immunology; Immunization; Lipid A / administration & dosage; Lipid A / analogs & derivatives; Swine
TL;DR: This study investigated whether nHgbAI dispensed with monophosphoryl lipid A (MPL), an adjuvant approved for use in humans, offered protection against a challenge with H. ducreyi and found that a bivalent HgbA vaccine may be needed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2006 journal article

Immunization with the Haemophilus ducreyi hemoglobin receptor HgbA protects against infection in the swine model of chancroid

INFECTION AND IMMUNITY, 74(4), 2224–2232.

By: G. Afonina, I. Leduc, I. Nepluev, C. Jeter, P. Routh n, G. Almond n , P. Orndorff n, M. Hobbs*, C. Elkins *

MeSH headings : Animals; Antibodies, Bacterial / biosynthesis; Antibodies, Bacterial / blood; Antibodies, Bacterial / metabolism; Bacterial Proteins / administration & dosage; Bacterial Proteins / immunology; Binding Sites, Antibody; Carrier Proteins / administration & dosage; Carrier Proteins / immunology; Chancroid / immunology; Chancroid / microbiology; Chancroid / pathology; Chancroid / prevention & control; Disease Models, Animal; Haemophilus Vaccines / administration & dosage; Haemophilus Vaccines / immunology; Haemophilus ducreyi / immunology; Hemoglobins / metabolism; Immunoglobulin G / metabolism; Immunoglobulin G / physiology; Protein Binding / immunology; Swine
TL;DR: Data suggest continuing the development of an HgbA subunit vaccine to prevent chancroid, and suggests such a vaccine strategy might be applied to other bacterial pathogens with strict heme/iron requirements. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2005 journal article

Expression and localization of hypoxia inducible factor-1 alpha mRNA in the porcine ovary

Canadian Journal of Veterinary Research, 69(3), 215–222.

By: U. Boonyaprakob, J. Gadsby , V. Hedgpeth, P. Routh & G. Almond 

Source: NC State University Libraries
Added: August 6, 2018

2004 journal article

Effects of dietary zinc on performance and immune response of growing pigs inoculated with porcine reproductive and respiratory syndrome virus and mycoplasma hyopneumoniae

ASIAN-AUSTRALASIAN JOURNAL OF ANIMAL SCIENCES, 17(10), 1438–1446.

By: E. Roberts  n, E. Heugten  n, J. Spears n, P. Routh n, K. Lloyd n & G. Almond n 

author keywords: pigs; PRRSv; zinc; growth; immune response
TL;DR: The data suggest that PRRSv and M. hyopneumoniae act to produce some performance deficits and the influence of Zn supplementation of nursery age pigs does not have clear effect in grower pigs affected with disease. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2003 journal article

Cloning of pig prostaglandin F-2 alpha(FP) receptor cDNA and expression of its mRNA in the corpora lutea

Reproduction (Cambridge, England), 125(1), 53–64.

By: U. Boonyaprakob n, J. Gadsby* , V. Hedgpeth*, P. Routh* & G. Almond* 

TL;DR: It is demonstrated that FPr is expressed in pig corpora lutea throughout the oestrous cycle and that upregulation of the FPr mRNA occurs when the corporaLutea becomes sensitive to PGF(2alpha). (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018

2003 journal article

Expression and localization of vascular endothelial growth factor and its receptors in pig corpora lutea during the oestrous cycle

Reproduction (Cambridge, England), 126(3), 393–405.

By: U. Boonyaprakob*, J. Gadsby n , V. Hedgpeth n, P. Routh* & G. Almond* 

MeSH headings : Animals; Blotting, Northern / methods; Corpus Luteum / chemistry; Corpus Luteum / physiology; Estrous Cycle / physiology; Female; Follicular Phase / physiology; In Situ Hybridization / methods; Luteal Phase / physiology; RNA, Messenger / analysis; Receptors, Vascular Endothelial Growth Factor / genetics; Swine / physiology; Vascular Endothelial Growth Factor A / genetics; Vascular Endothelial Growth Factor Receptor-1 / genetics; Vascular Endothelial Growth Factor Receptor-2 / genetics
TL;DR: Data indicate that the VEGF system may be involved in the regulation of luteal vasculature throughout the lifespan of the corpus luteum, and variations in the expression of V EGFR-1 and VEGFR-2 mRNAs indicate that differential regulation of expression of the V EGF receptors may play a role in the control of VEGf-mediated vascular growth at different phases of development and maturation of the pig corpus lutenum. (via Semantic Scholar)
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018

2000 journal article

Experimental Salmonella typhi infection in the domestic pig, Sus scrofa domestica

MICROBIAL PATHOGENESIS, 29(2), 121–126.

By: E. Metcalf*, G. Almond n , P. Routh n, . Horton  n, R. Dillman n & P. Orndorff n

author keywords: Salmonella; typhi; choleraesuis; pig; tonsil; typhoid fever
MeSH headings : Animals; Disease Models, Animal; Female; Humans; Palatine Tonsil / microbiology; Salmonella / growth & development; Salmonella / pathogenicity; Salmonella Infections, Animal / microbiology; Salmonella typhi / growth & development; Salmonella typhi / pathogenicity; Swine; Swine Diseases / microbiology; Typhoid Fever / microbiology; Virulence
TL;DR: The observation of tonsillar involvement was consistent with former observations of S. choleraesuis and S. typhimurium infections in swine and supports a role for the tonsil in all porcine salmonella infections. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

1999 journal article

Effects of immune challenge on concentrations of serum insulin- like growth factor-I and growth performance in pigs

Canadian Veterinary Journal, 40(11), 782–786.

By: W. Hevener, P. Routh & G. Almond 

Source: NC State University Libraries
Added: August 6, 2018

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