Patricia A. Routh

Works (13)

Updated: July 18th, 2023 21:18

2017 journal article

Evaluation of a 2-aminoimidazole variant as adjuvant treatment for dermal bacterial infections

Drug Design Development and Therapy, 11, 153–162.

By: G. Draughn, C. Allen, P. Routh, M. Stone, K. Kirker, A. Boegli, R. Schuchman, K. Linder ...

Source: NC State University Libraries
Added: August 6, 2018

2016 article

Pharmacokinetics of 14C‐ortho‐phenylphenol following intravenous administration in pigs

Nixon, E., Brooks, J. D., Routh, P. A., Chittenden, J. T., & Baynes, R. E. (2016, September 4). Journal of Applied Toxicology, Vol. 37, pp. 508–512.

By: E. Nixon n , J. Brooks n, P. Routh n, J. Chittenden * & R. Baynes n 

author keywords: pharmacokinetics; ortho-phenylphenol; intravenous dose; pig; biocide
MeSH headings : Administration, Intravenous; Animals; Area Under Curve; Biphenyl Compounds / administration & dosage; Biphenyl Compounds / pharmacokinetics; Disinfectants / pharmacokinetics; Feces / chemistry; Half-Life; Male; Sus scrofa; Swine; Tissue Distribution
topics (OpenAlex): Carcinogens and Genotoxicity Assessment; Effects and risks of endocrine disrupting chemicals; Animal testing and alternatives
TL;DR: Comparisons with other species suggest that 14C‐OPP clearance in pigs (2.48 ml h–1 kg–1) is less than that in humans and rats and that the kidneys play a crucial role in clearance with a large percentage of the dose being found in the urine. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2014 article

The Haemophilus ducreyi trimeric autotransporter adhesin DsrA protects against an experimental infection in the swine model of chancroid

Fusco, W. G., Choudhary, N. R., Routh, P. A., Ventevogel, M. S., Smith, V. A., Koch, G. G., … Leduc, I. (2014, May 18). Vaccine, Vol. 32, pp. 3752–3758.

By: W. Fusco *, N. Choudhary*, P. Routh n, M. Ventevogel*, V. Smith *, G. Koch*, G. Almond n , P. Orndorff n, G. Sempowski *, I. Leduc*

author keywords: Haemophilus ducreyi; Trimeric autotransporter adhesin; DsrA; Active protection
MeSH headings : Adhesins, Bacterial / immunology; Adjuvants, Immunologic / administration & dosage; Animals; Antibodies, Bacterial / blood; Bacterial Vaccines / immunology; Chancroid / prevention & control; Disease Models, Animal; Fibrinogen / metabolism; Haemophilus ducreyi; Immune Sera / immunology; Immunity, Humoral; Immunoglobulin G / blood; Recombinant Proteins / immunology; Sus scrofa
topics (OpenAlex): Syphilis Diagnosis and Treatment; Virology and Viral Diseases; Reproductive tract infections research
TL;DR: Overall, immunization with the passenger domain of the trimeric autotransporter adhesin DsrA accelerated clearance of H. ducreyi in experimental lesions, possibly by interfering with fibrinogen binding. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 article

The effect of breed and sex on sulfamethazine, enrofloxacin, fenbendazole and flunixin meglumine pharmacokinetic parameters in swine

Howard, J. T., Baynes, R. E., Brooks, J. D., Yeatts, J. L., Bellis, B., Ashwell, M. S., … Maltecca, C. (2014, April 15). Journal of Veterinary Pharmacology and Therapeutics, Vol. 37, pp. 531–541.

By: J. Howard  n, R. Baynes n , J. Brooks n, J. Yeatts n, B. Bellis n, M. Ashwell n , P. Routh n, A. O'Nan n, C. Maltecca n 

Contributors: J. Howard  n, R. Baynes n , J. Brooks n, J. Yeatts n, B. Bellis n, M. Ashwell n , P. Routh n, . A.T. O'Nan n, C. Maltecca n 

MeSH headings : Animals; Anti-Infective Agents / blood; Anti-Infective Agents / pharmacokinetics; Anti-Inflammatory Agents, Non-Steroidal / blood; Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics; Antinematodal Agents / blood; Antinematodal Agents / pharmacokinetics; Benzimidazoles / blood; Ciprofloxacin / blood; Clonixin / analogs & derivatives; Clonixin / blood; Clonixin / pharmacokinetics; Enrofloxacin; Female; Fenbendazole / blood; Fenbendazole / pharmacokinetics; Fluoroquinolones / blood; Fluoroquinolones / pharmacokinetics; Male; Sex Factors; Species Specificity; Sulfamethazine / analogs & derivatives; Sulfamethazine / blood; Sulfamethazine / pharmacokinetics; Swine / metabolism
topics (OpenAlex): Antibiotics Pharmacokinetics and Efficacy; Drug Transport and Resistance Mechanisms; Pharmacogenetics and Drug Metabolism
TL;DR: Whether drug clearance differs across genetic backgrounds and sex for sulfamethazine, enrofloxacin, fenbendazole and flunixin meglumine is determined to determine the degree of additive genetic variation utilizing a larger population. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2011 article

Passive Immunization with a Polyclonal Antiserum to the Hemoglobin Receptor of Haemophilus ducreyi Confers Protection against a Homologous Challenge in the Experimental Swine Model of Chancroid

Leduc, I., Fusco, W. G., Choudhary, N., Routh, P. A., Cholon, D. M., Hobbs, M. M., … Elkins, C. (2011, June 7). Infection and Immunity, Vol. 79, pp. 3168–3177.

By: I. Leduc*, W. Fusco *, N. Choudhary*, P. Routh n, D. Cholon *, M. Hobbs*, G. Almond n , P. Orndorff n, C. Elkins *

MeSH headings : Animals; Antibodies, Bacterial / administration & dosage; Antibodies, Bacterial / immunology; Bacterial Proteins / immunology; Carrier Proteins / immunology; Chancroid / immunology; Chancroid / pathology; Chancroid / prevention & control; Disease Models, Animal; Ear / pathology; Haemophilus ducreyi / immunology; Haemophilus ducreyi / pathogenicity; Histocytochemistry; Immune Sera / administration & dosage; Immune Sera / immunology; Immunization, Passive / methods; Microbial Viability; Microscopy; Receptors, Cell Surface / immunology; Swine; Swine Diseases / immunology; Swine Diseases / prevention & control
topics (OpenAlex): Syphilis Diagnosis and Treatment; Blood groups and transfusion; Reproductive tract infections research
TL;DR: Data suggest that the humoral immune response to the HgbA vaccine is protective against an H. ducreyi infection, possibly by preventing acquisition of the essential nutrient heme. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2010 article

Immunization with theHaemophilus ducreyiHemoglobin Receptor HgbA with Adjuvant Monophosphoryl Lipid A Protects Swine from a Homologous but Not a Heterologous Challenge

Fusco, W. G., Afonina, G., Nepluev, I., Cholon, D. M., Choudhary, N., Routh, P. A., … Elkins, C. (2010, June 29). Infection and Immunity, Vol. 78, pp. 3763–3772.

By: W. Fusco *, G. Afonina*, I. Nepluev*, D. Cholon *, N. Choudhary*, P. Routh n, G. Almond n , P. Orndorff n ...

MeSH headings : Adjuvants, Immunologic / administration & dosage; Animals; Antibodies, Bacterial / blood; Bacterial Proteins / genetics; Bacterial Proteins / immunology; Bacterial Vaccines / immunology; Carrier Proteins / genetics; Carrier Proteins / immunology; Chancroid / prevention & control; Enzyme-Linked Immunosorbent Assay; Haemophilus ducreyi / immunology; Immune Sera / immunology; Immunization; Lipid A / administration & dosage; Lipid A / analogs & derivatives; Swine
topics (OpenAlex): Syphilis Diagnosis and Treatment; Reproductive tract infections research; Virology and Viral Diseases
TL;DR: This study investigated whether nHgbAI dispensed with monophosphoryl lipid A (MPL), an adjuvant approved for use in humans, offered protection against a challenge with H. ducreyi and found that a bivalent HgbA vaccine may be needed. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2006 article

Immunization with theHaemophilus ducreyiHemoglobin Receptor HgbA Protects against Infection in the Swine Model of Chancroid

Afonina, G., Leduc, I., Nepluev, I., Jeter, C., Routh, P., Almond, G., … Elkins, C. (2006, March 21). Infection and Immunity, Vol. 74, pp. 2224–2232.

By: G. Afonina, I. Leduc, I. Nepluev, C. Jeter, P. Routh n, G. Almond n , P. Orndorff n, M. Hobbs*, C. Elkins *

MeSH headings : Animals; Antibodies, Bacterial / biosynthesis; Antibodies, Bacterial / blood; Antibodies, Bacterial / metabolism; Bacterial Proteins / administration & dosage; Bacterial Proteins / immunology; Binding Sites, Antibody; Carrier Proteins / administration & dosage; Carrier Proteins / immunology; Chancroid / immunology; Chancroid / microbiology; Chancroid / pathology; Chancroid / prevention & control; Disease Models, Animal; Haemophilus Vaccines / administration & dosage; Haemophilus Vaccines / immunology; Haemophilus ducreyi / immunology; Hemoglobins / metabolism; Immunoglobulin G / metabolism; Immunoglobulin G / physiology; Protein Binding / immunology; Swine
topics (OpenAlex): Syphilis Diagnosis and Treatment; Blood groups and transfusion; Reproductive tract infections research
TL;DR: Data suggest continuing the development of an HgbA subunit vaccine to prevent chancroid, and suggests such a vaccine strategy might be applied to other bacterial pathogens with strict heme/iron requirements. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2005 journal article

Expression and localization of hypoxia inducible factor-1 alpha mRNA in the porcine ovary

Canadian Journal of Veterinary Research, 69(3), 215–222.

By: U. Boonyaprakob, J. Gadsby , V. Hedgpeth, P. Routh & G. Almond 

Source: NC State University Libraries
Added: August 6, 2018

2004 article

Effects of Dietary Zinc on Performance and Immune Response of Growing Pigs Inoculated with Porcine Reproductive and Respiratory Syndrome Virus and Mycoplasma hyopneumoniae

Roberts, E. S., Heugten, E., Spears, J. W., Routh, P. A., Lloyd, K. L., & Almond, G. W. (2004, January 1). Asian-Australasian Journal of Animal Sciences, Vol. 17, pp. 1438–1446.

By: E. Roberts  n, E. Heugten n , J. Spears n, P. Routh n, K. Lloyd n & G. Almond n 

author keywords: pigs; PRRSv; zinc; growth; immune response
topics (OpenAlex): Animal Virus Infections Studies; Viral gastroenteritis research and epidemiology; Microbial infections and disease research
TL;DR: The data suggest that PRRSv and M. hyopneumoniae act to produce some performance deficits and the influence of Zn supplementation of nursery age pigs does not have clear effect in grower pigs affected with disease. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2003 article

Cloning of pig prostaglandin F2alphaFP receptor cDNA and expression of its mRNA in the corpora lutea

Boonyaprakob, U., Gadsby, J. E., Hedgpeth, V., Routh, P., & Almond, G. W. (2003, January 1). Reproduction, Vol. 125, pp. 53–64.

By: U. Boonyaprakob n, J. Gadsby n , V. Hedgpeth n, P. Routh* & G. Almond n 

topics (OpenAlex): Reproductive Physiology in Livestock; Genetic and phenotypic traits in livestock; Animal Behavior and Welfare Studies
TL;DR: It is demonstrated that FPr is expressed in pig corpora lutea throughout the oestrous cycle and that upregulation of the FPr mRNA occurs when the corporaLutea becomes sensitive to PGF(2alpha). (via Semantic Scholar)
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15. Life on Land (OpenAlex)
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018

2003 article

Expression and localization of vascular endothelial growth factor and its receptors in pig corpora lutea during the oestrous cycle

Boonyaprakob, U., Gadsby, J. E., Hedgpeth, V., Routh, P., & Almond, G. W. (2003, September 1). Reproduction, Vol. 126, pp. 393–405.

By: U. Boonyaprakob*, J. Gadsby n , V. Hedgpeth n, P. Routh* & G. Almond* 

MeSH headings : Animals; Blotting, Northern / methods; Corpus Luteum / chemistry; Corpus Luteum / physiology; Estrous Cycle / physiology; Female; Follicular Phase / physiology; In Situ Hybridization / methods; Luteal Phase / physiology; RNA, Messenger / analysis; Receptors, Vascular Endothelial Growth Factor / genetics; Swine / physiology; Vascular Endothelial Growth Factor A / genetics; Vascular Endothelial Growth Factor Receptor-1 / genetics; Vascular Endothelial Growth Factor Receptor-2 / genetics
topics (OpenAlex): Angiogenesis and VEGF in Cancer; Reproductive Physiology in Livestock; Veterinary Equine Medical Research
TL;DR: Data indicate that the VEGF system may be involved in the regulation of luteal vasculature throughout the lifespan of the corpus luteum, and variations in the expression of V EGFR-1 and VEGFR-2 mRNAs indicate that differential regulation of expression of the V EGF receptors may play a role in the control of VEGf-mediated vascular growth at different phases of development and maturation of the pig corpus lutenum. (via Semantic Scholar)
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018

2000 article

Experimental Salmonella typhi infection in the domestic pig, Sus scrofa domestica

Metcalf, E. S., Almond, G. W., Routh, P. A., Horton, J. R., Dillman, R. C., & Orndorff, P. E. (2000, August 1). Microbial Pathogenesis, Vol. 29, pp. 121–126.

By: E. Metcalf*, G. Almond n , P. Routh n, J. Horton n, R. Dillman n & P. Orndorff n

author keywords: Salmonella; typhi; choleraesuis; pig; tonsil; typhoid fever
MeSH headings : Animals; Disease Models, Animal; Female; Humans; Palatine Tonsil / microbiology; Salmonella / growth & development; Salmonella / pathogenicity; Salmonella Infections, Animal / microbiology; Salmonella typhi / growth & development; Salmonella typhi / pathogenicity; Swine; Swine Diseases / microbiology; Typhoid Fever / microbiology; Virulence
topics (OpenAlex): Salmonella and Campylobacter epidemiology; Viral gastroenteritis research and epidemiology; Vibrio bacteria research studies
TL;DR: The observation of tonsillar involvement was consistent with former observations of S. choleraesuis and S. typhimurium infections in swine and supports a role for the tonsil in all porcine salmonella infections. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

1999 journal article

Effects of immune challenge on concentrations of serum insulin- like growth factor-I and growth performance in pigs

Canadian Veterinary Journal, 40(11), 782–786.

By: W. Hevener, P. Routh & G. Almond 

Source: NC State University Libraries
Added: August 6, 2018

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