Works (1)
Updated: July 5th, 2023 16:02
2000 journal article
Molecular evolution of the GATA family of transcription factors: Conservation within the DNA-binding domain
JOURNAL OF MOLECULAR EVOLUTION, 50(2), 103–115.
author keywords: GATA; transcription factor; zinc finger; DNA binding domain; phylogeny; Boltzmann entropy; predictive motif
MeSH headings : Amino Acid Motifs; Amino Acid Sequence; Binding Sites; Conserved Sequence; DNA-Binding Proteins / physiology; Erythroid-Specific DNA-Binding Factors; Evolution, Molecular; Models, Molecular; Molecular Sequence Data; Phylogeny; Protein Structure, Tertiary; Transcription Factors / physiology; Zinc Fingers
TL;DR:
It is shown that only the C-terminal zinc finger and basic domain, which together constitute the GATA-binding domain, are conserved throughout this protein family, and multiple modes of evolution are suggested, including gene duplication and modular evolution of GATA factors based upon inclusion of a class IV zinc finger motif.
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