@article{birdsall_zimmerman_teeter_gibson_2000, title={Genetic variation for the positioning of wing veins in Drosophila melanogaster}, volume={2}, ISSN={["1525-142X"]}, DOI={10.1046/j.1525-142x.2000.00034.x}, abstractNote={SUMMARY To define the components of variation for wing shape in Drosophila in relation to what is known about the developmental control of wing patterning, we have characterized shape variation in the wings of 12 randomly chosen highly inbred lines. Despite large differences in wing size between males and females, and between flies reared at 18°C or 25°C, wing shape is remarkably unaffected by these variables and is highly line specific. The shape of each intervein region of the wing appears to be independently regulated at the genetic level, consistent with the role of secreted growth factors in establishing the locations of wing veins. Sex and temperature were found to have different effects on cell number in two intervein regions, with the result that wing shape is to a large extent independent of cell density. Dietary cholesterol was also shown to affect the breadth of the central intervein region, consistent with an effect on the strength of Hedgehog signaling during wing development. We conclude that wing shape is under tighter genetic control than wing size, and hypothesize that this control is achieved in large part by gene activity at the level of wing vein determination and differentiation.}, number={1}, journal={EVOLUTION & DEVELOPMENT}, author={Birdsall, K and Zimmerman, E and Teeter, K and Gibson, G}, year={2000}, pages={16–24} } @article{teeter_naeemuddin_gasperini_zimmerman_white_hoskins_gibson_2000, title={Haplotype dimorphism in a SNP collection from Drosophila melanogaster}, volume={288}, ISSN={["0022-104X"]}, DOI={10.1002/(SICI)1097-010X(20000415)288:1<63::AID-JEZ7>3.0.CO;2-1}, abstractNote={A moderate resolution single nucleotide polymorphism (SNP) map of the genome of Drosophila melanogaster that is designed for use in quantitative genetic mapping is described. Seventeen approximately 500 nucleotide gene sequences spaced at 10 to 20 centimorgan intervals were combined with 49 shorter sequence tag sites (STSs) at 5 to 10 centimorgan intervals to generate a map that should not leave any gaps greater than one half of a chromosome arm when any two wild type lines are compared. Of 20 markers with sufficient polymorphism to construct haplotype cladograms, 13 showed evidence for two divergent classes of haplotype. The possible mechanisms for and implications of the unexpected finding that two thirds of all short gene sequences in D. melanogaster may be dimorphic are discussed, including the suggestion that admixture between two separate lineages may have been a major event in the history of the species.}, number={1}, journal={JOURNAL OF EXPERIMENTAL ZOOLOGY}, author={Teeter, K and Naeemuddin, M and Gasperini, R and Zimmerman, E and White, KP and Hoskins, R and Gibson, G}, year={2000}, month={Apr}, pages={63–75} } @article{zimmerman_palsson_gibson_2000, title={Quantitative trait loci affecting components of wing shape in Drosophila melanogaster}, volume={155}, number={2}, journal={Genetics}, author={Zimmerman, E. and Palsson, A. and Gibson, G.}, year={2000}, pages={671–683} }