Benjamin Lester Holley

Works (5)

Updated: July 5th, 2023 16:01

2004 journal article

The effect of mutation on RNA Diels-Alderases

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 126(38), 11843–11851.

By: T. Tarasow  n, E. Kellogg  n, B. Holley n, D. Nieuwlandt n, S. Tarasow n & B. Eaton n

MeSH headings : Base Sequence; Catalysis; Cations; Conserved Sequence; Gene Library; Kinetics; Metals / chemistry; Metals / metabolism; Molecular Sequence Data; Mutagenesis; Nucleic Acid Conformation; RNA, Catalytic / chemistry; RNA, Catalytic / genetics; RNA, Catalytic / metabolism; Sequence Alignment; Structure-Activity Relationship; Thermodynamics
TL;DR: One of the most active Diels-Alderases (DAM 40), a subtle sequence mutant of DA22, was found to show a new metal dependence and could function with Ni(2+) as the only transition-metal ion. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2003 journal article

Alpha lipoic acid changes iron uptake and storage in lens epithelial cells

EXPERIMENTAL EYE RESEARCH, 76(2), 241–248.

By: M. Goralska n, R. Dackor n, B. Holley n & M. McGahan  n

author keywords: alpha lipoic acid (LA); Fe; ferritin; oxidative damage; calcein; labile Fe pool
MeSH headings : Animals; Antioxidants / pharmacology; Ascorbic Acid / pharmacology; Cells, Cultured; Dogs; Dose-Response Relationship, Drug; Epithelial Cells / drug effects; Epithelial Cells / metabolism; Ferritins / biosynthesis; Ferritins / metabolism; Hydrogen Peroxide / antagonists & inhibitors; Hydrogen Peroxide / pharmacology; Iron / pharmacokinetics; Lens Capsule, Crystalline / cytology; Lens Capsule, Crystalline / drug effects; Lens Capsule, Crystalline / metabolism; Oxidative Stress / drug effects; Thioctic Acid / pharmacology
TL;DR: In vivo effects of lipoic acid treatment on Fe metabolism in cultured lens epithelial cells are examined, and it is found that LA decreases Fe uptake from transferrin, increases Fe deposition into ferritin and increases the concentration of this protein. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2003 journal article

Identification of a mechanism by which lens epithelial cells limit accumulation of overexpressed ferritin H-chain

JOURNAL OF BIOLOGICAL CHEMISTRY, 278(44), 42920–42926.

By: M. Goralska n, B. Holley n & M. McGahan  n

MeSH headings : Animals; Apoferritins; Blotting, Western; Cataract / metabolism; Cytosol / metabolism; DNA, Complementary / metabolism; Dogs; Electrophoresis, Polyacrylamide Gel; Epithelial Cells / metabolism; Eye Diseases, Hereditary / metabolism; Ferritins / biosynthesis; Ferritins / chemistry; Ferritins / metabolism; Humans; Iron Metabolism Disorders; Lens, Crystalline / metabolism; Mutation; Peptides / chemistry; Plasmids / metabolism; Precipitin Tests; RNA, Messenger / metabolism; Recombinant Proteins / metabolism; Time Factors; Transfection
TL;DR: It is concluded that lens epithelial cells differentially regulate concentration of both ferritin chains in the cytosol, which indicates that the inability of cells to more strictly control cytosolic levels of L-chain may augment its accumulation in lenses of humans with hereditary hyperferritinemia cataract syndrome. (via Semantic Scholar)
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Added: August 6, 2018

2001 journal article

Overexpression of H- and L-ferritin subunits in lens epithelial cells: Fe metabolism and cellular response to UVB irradiation

Investigative Ophthalmology and Visual Science, 42(8), 1721–1727.

By: M. Goralska, B. Holley & M. McGahan

Source: NC State University Libraries
Added: August 6, 2018

2000 journal article

The effects of Tempol on ferritin synthesis and Fe metabolism in lens epithelial cells

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 1497(1), 51–60.

By: M. Goralska n, B. Holley n & M. McGahan  n

author keywords: ferritin; Fe metabolism; lens; cataract; lens epithelial cell; tempol; oxidative damage; peroxide; free radical
MeSH headings : Animals; Antioxidants / pharmacology; Cyclic N-Oxides / pharmacology; Dogs; Dose-Response Relationship, Drug; Epithelial Cells / cytology; Epithelial Cells / drug effects; Epithelial Cells / metabolism; Female; Ferritins / biosynthesis; Ferritins / drug effects; Iron / metabolism; Lens, Crystalline / cytology; Lens, Crystalline / drug effects; Lens, Crystalline / metabolism; Male; Spin Labels; Time Factors; tert-Butylhydroperoxide / pharmacology
TL;DR: The redistribution of Fe within the cell after 20 h of Tempol treatment appears to render the cells more vulnerable to oxidative stress, likely due to its effects on Fe metabolism, perhaps by reducing the availability of Fe for incorporation into ferritin and Fe-dependent enzymes as well as enlarging a low molecular weight pool of Fe which may be capable of catalyzing damaging free radical reactions. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

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