Allen Worth Olmstead

Works (12)

Updated: July 5th, 2023 16:01

2006 journal article

A candidate juvenoid hormone receptor cis-element in the Daphnia magna hb2 hemoglobin gene promoter

MOLECULAR AND CELLULAR ENDOCRINOLOGY, 247(1-2), 91–102.

By: T. Gorr *, C. Rider n, H. Wang n, A. Olmstead n & G. LeBlanc n 

author keywords: methyl farnesoate; juvenoid; crustacean; response element; sex determination
MeSH headings : Animals; Base Sequence; Cycloheximide / pharmacology; Daphnia / genetics; Daphnia / physiology; Fatty Acids, Unsaturated / metabolism; Hemoglobins / biosynthesis; Hemoglobins / genetics; Hemoglobins / physiology; Juvenile Hormones / metabolism; Molecular Sequence Data; Promoter Regions, Genetic; Pyridines / metabolism; RNA, Messenger / biosynthesis; Receptors, Cytoplasmic and Nuclear / genetics; Receptors, Cytoplasmic and Nuclear / metabolism; Response Elements; Signal Transduction
TL;DR: Induction of hb2 by juvenoids was not dependent upon the synthesis of secondary transcription factors that bound the JRE but was likely due to activation of the gene directly by the juvenoid-receptor complex. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2005 journal article

Joint action of polycyclic aromatic hydrocarbons: Predictive modeling of sublethal toxicity

AQUATIC TOXICOLOGY, 75(3), 253–262.

By: A. Olmstead n & G. LeBlanc n 

author keywords: hazard assessment; risk assessment; response addition; synergy; mixture toxicology
MeSH headings : Algorithms; Animals; Daphnia / drug effects; Daphnia / growth & development; Dose-Response Relationship, Drug; Models, Biological; Polycyclic Aromatic Hydrocarbons / toxicity; Toxicology / methods
TL;DR: Results indicate that PAHs elicit toxicity to daphnids by multiple mechanisms and demonstrate an appropriate modeling approach to assess the toxicity of these PAH mixtures. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2005 journal article

Stress signaling: coregulation of hemoglobin and male sex determination through a terpenoid signaling pathway in a crustacean

JOURNAL OF EXPERIMENTAL BIOLOGY, 208(1), 15–23.

By: C. Rider n, T. Gorr *, A. Olmstead n, B. Wasilak n & G. Leblanc n 

author keywords: Cladocera; juvenoid; endocrine disruption; evolution; nuclear receptor; Daphnia magna
MeSH headings : Analysis of Variance; Animals; Base Sequence; DNA Primers; Daphnia / physiology; Electrophoresis; Fatty Acids, Unsaturated / pharmacology; Hemoglobins / genetics; Hemoglobins / metabolism; Male; Molecular Sequence Data; Reproduction / physiology; Reverse Transcriptase Polymerase Chain Reaction; Sequence Analysis, DNA; Sex Differentiation / drug effects; Signal Transduction / physiology; Spectrophotometry; Stress, Physiological / metabolism; Terpenes / metabolism
TL;DR: It is demonstrated that two responses to environmental stress signaling in the crustacean Daphnia magna - hemoglobin accumulation and male offspring production - are co-elevated by the crustACEan terpenoid hormone methyl farnesoate and several synthetic analogs, suggesting that both processes are regulated by the same ter penoid signaling pathway. (via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action (Web of Science)
14. Life Below Water (OpenAlex)
15. Life on Land (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2005 journal article

The screening of chemicals for juvenoid-related endocrine activity using the water flea Daphnia magna

AQUATIC TOXICOLOGY, 74(3), 193–204.

By: H. Wang n, A. Olmstead n, H. Li n & G. LeBlanc n 

author keywords: endocrine disruptors; screening; juvenoids; sex determination
MeSH headings : Animals; Benzhydryl Compounds; Daphnia / drug effects; Daphnia / metabolism; Ecdysteroids / metabolism; Ecdysteroids / pharmacology; Endocrine System / drug effects; Endpoint Determination / methods; Fatty Acids, Unsaturated / pharmacology; Female; Juvenile Hormones / agonists; Juvenile Hormones / antagonists & inhibitors; Juvenile Hormones / metabolism; Male; Methoprene / pharmacology; Pesticides / toxicity; Phenols / toxicity; Phytol / pharmacology; Pyridines / pharmacology; Reproducibility of Results; Sex Differentiation / drug effects; Toxicity Tests / methods; Tretinoin / pharmacology; United States; United States Environmental Protection Agency
TL;DR: Results demonstrate that an in vivo assay with a crustacean species customarily employed in toxicity testing can be used to effectively screen chemicals for juvenoid-modulating activity. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2005 journal article

Toxicity Assessment of Environmentally Relevant Pollutant Mixtures Using a Heuristic Model

INTEGRATED ENVIRONMENTAL ASSESSMENT AND MANAGEMENT, 1(2), 114–122.

By: A. Olmstead n & G. LeBlanc n 

author keywords: Mixture toxicology; Mixture model; Daphnid; Insecticides; Pollutants
MeSH headings : Animals; Daphnia; Endpoint Determination; Environmental Pollutants / toxicity; Forecasting; Models, Theoretical; Sensitivity and Specificity; Xenobiotics / toxicity
TL;DR: Toxicity was not influenced significantly by interactions among the chemicals and a single constituent dominated toxicity, and the median detected environmental concentrations of chemicals constituting this mixture provided no margin of safety. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2004 personal communication

Evaluating the toxicity of chemical mixtures

LeBlanc, G. A., & Olmstead, A. W. (2004, September).

By: G. LeBlanc*  & A. Olmstead*

MeSH headings : Animals; Data Interpretation, Statistical; Drug Interactions; Endocrine System / drug effects; Estrogens / toxicity; Estrogens, Non-Steroidal / toxicity; Female; Rats; Uterus / drug effects; Uterus / growth & development
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2004 journal article

Non-target toxicology of a new mosquito larvicide, trypsin modulating oostatic factor

PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, 80(3), 131–142.

By: D. Thompson n, H. Young n, F. Edens n, A. Olmstead n, G. LeBlanc n , E. Hodgson n, R. Roe n 

author keywords: trypsin modulating oostatic factor; TMOF; insecticide; mosquito; mouse; rabbit; duck; water flea
TL;DR: It appears from these studies that T MOF can be degraded by vertebrate digestive proteases and technical TMOF is not toxic to the non-target organisms examined. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2003 journal article

Insecticidal juvenile hormone analogs stimulate the production of male offspring in the crustacean Daphnia magna

ENVIRONMENTAL HEALTH PERSPECTIVES, 111(7), 919–924.

By: A. Olmstead n & G. LeBlanc n 

author keywords: crustacea; Daphnia; endocrine disruption; invertebrate; methoprene; methyl farnesoate; mixtures; pyriproxyfen
MeSH headings : Animals; Daphnia / physiology; Female; Juvenile Hormones / chemistry; Juvenile Hormones / pharmacology; Male; Sex Ratio
TL;DR: It is demonstrated that insecticidal JHAs mimic the action of the crustacean juvenoid hormone methyl farnesoate, resulting in the inappropriate production of male offspring. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2002 journal article

Juvenoid hormone methyl farnesoate is a sex determinant in the crustacean Daphnia magna

JOURNAL OF EXPERIMENTAL ZOOLOGY, 293(7), 736–739.

By: A. Olmstead n & G. Leblanc n 

MeSH headings : Animals; Daphnia / drug effects; Daphnia / embryology; Daphnia / growth & development; Daphnia / physiology; Environment; Fatty Acids, Unsaturated / administration & dosage; Fatty Acids, Unsaturated / pharmacology; Female; Juvenile Hormones / administration & dosage; Juvenile Hormones / pharmacology; Male; Reproduction; Sex Differentiation / drug effects; Time Factors
TL;DR: Results demonstrate that methyl farnesoate is capable of programming daphnid embryos to develop into males and is likely the endocrine factor responsible for initiating the sexual reproductive phase in these organisms. (via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action (Web of Science)
14. Life Below Water (OpenAlex)
15. Life on Land (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2001 journal article

Low Exposure Concentration Effects of Methoprene on Endocrine-Regulated Processes in the Crustacean Daphnia magna

Toxicological Sciences, 62(2), 268–273.

By: A. Olmstead n & G. Le Blanc

author keywords: methoprene; daphnid; crustacea; endocrine disruption; methyl farnesoate
MeSH headings : Animals; Daphnia / drug effects; Daphnia / growth & development; Daphnia / physiology; Dose-Response Relationship, Drug; Endocrine Glands / drug effects; Endocrine Glands / physiology; Fertility; Juvenile Hormones / toxicity; Methoprene / toxicity; Reproduction
TL;DR: It is demonstrated that methoprene elicits significant toxicity to endocrine-related processes in the 5-50 nM concentration range, and molting and reproduction were impacted at significantly lower meethoprene concentrations, with a distinct concentration response and a threshold of < or =0.2 nM. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
14. Life Below Water (OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2001 journal article

Temporal and quantitative changes in sexual reproductive cycling of the cladoceran Daphnia magna by a juvenile hormone analog

JOURNAL OF EXPERIMENTAL ZOOLOGY, 290(2), 148–155.

By: A. Olmstead n & G. LeBlanc n 

MeSH headings : Animals; Daphnia / physiology; Female; Juvenile Hormones / physiology; Male; Methoprene / pharmacology; Parthenogenesis; Reproduction
TL;DR: It is demonstrated that methoprene uncouples the coordinate production of males and resting eggs during the sexual reproductive period of D. magna. (via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action (Web of Science)
15. Life on Land (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2000 journal article

Effects of endocrine-active chemicals on the development of sex characteristics of Daphnia magna

ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, 19(8), 2107–2113.

By: A. Olmstead* & G. LeBlanc* 

author keywords: endocrine disruption; daphnid; sexual differentiation; invertebrate
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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