Paul E. Hoyle

Works (2)

Updated: July 5th, 2023 16:01

2001 article

Transforming growth factor-beta(1) modifies fibroblast growth factor-2 production in type II cells

Li, C. M., Khosla, J., Hoyle, P., & Sannes, P. L. (2001, July). CHEST, Vol. 120, pp. 60S–61S.

By: C. Li n, J. Khosla n, P. Hoyle n & P. Sannes n

author keywords: alveolar epithelium; extracellular matrix; growth factors
MeSH headings : Animals; Fibroblast Growth Factor 2 / biosynthesis; Pulmonary Alveoli / metabolism; Rats; Rats, Inbred F344; Transforming Growth Factor beta / physiology; Transforming Growth Factor beta1
TL;DR: Important regulatory links between FGF-2, sulfated ECMs, and both TGF-β 1 and FGF, which could contribute to the modulation of normal cell turnover, development, and repair processes attendant to fibrosis in the lung are demonstrated. (via Semantic Scholar)
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Added: August 6, 2018

2000 journal article

TGF-beta 1 and fibroblast growth factor-1 modify fibroblast growth factor-2 production in type II cells

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 279(6), L1038–L1046.

By: C. Li n, J. Khosla n, I. Pagan n, P. Hoyle n & P. Sannes n

author keywords: basic fibroblast growth factor; acidic fibroblast growth factor; alveolar epithelium; alveolar injury; pulmonary fibrosis; transforming growth factor
MeSH headings : Animals; Cells, Cultured; Dose-Response Relationship, Drug; Fibroblast Growth Factor 1; Fibroblast Growth Factor 2 / genetics; Fibroblast Growth Factor 2 / pharmacology; Gene Expression / drug effects; Pulmonary Alveoli / cytology; Pulmonary Alveoli / metabolism; Pulmonary Fibrosis / metabolism; RNA, Messenger / analysis; Rats; Rats, Inbred F344; Receptor Protein-Tyrosine Kinases / genetics; Receptor, Fibroblast Growth Factor, Type 1; Receptors, Fibroblast Growth Factor / genetics; Specific Pathogen-Free Organisms; Transforming Growth Factor beta / pharmacology
TL;DR: Fibroblast growth factor (FGF)-2, which stimulates DNA synthesis by type II cells in the lung, has been shown to be regulated by transforming growth factors (TGF)-β1, an important inflammatory cytokine. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

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