Works (8)
Updated: July 5th, 2023 16:01
2008 journal article
AAV vector-mediated reversal of hypoglycemia in canine and murine glycogen storage disease type Ia
MOLECULAR THERAPY, 16(4), 665–672.
MeSH headings : Animals; Dependovirus / genetics; Disease Models, Animal; Dogs; Genetic Therapy; Genetic Vectors; Glucose-6-Phosphatase / biosynthesis; Glucose-6-Phosphatase / genetics; Glycogen Storage Disease Type I / enzymology; Glycogen Storage Disease Type I / therapy; Humans; Hypoglycemia / enzymology; Hypoglycemia / therapy; Liver Glycogen / metabolism; Mice; Mice, Knockout
TL;DR:
The AAV2/8 vector uniquely prevented hypoglycemia during fasting and fully corrected liver G6Pase deficiency in GSD-Ia mice and dogs, and support the further preclinical development of AAV vector-mediated gene therapy for GSD -Ia.
(via Semantic Scholar)
open access via doi.org (publisher)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2006 journal article
Early, sustained efficacy of adeno-associated virus vector-mediated gene therapy in glycogen storage disease type Ia
GENE THERAPY, 13(17), 1281–1289.
author keywords: adeno-associated virus; glycogen storage disease; growth failure; metabolism; hypoglycemia; glucose-6-phosphatase
MeSH headings : Animals; CD4-Positive T-Lymphocytes / immunology; CD8-Positive T-Lymphocytes / immunology; Dependovirus / genetics; Genetic Therapy / methods; Genetic Vectors / administration & dosage; Genetic Vectors / genetics; Genetic Vectors / immunology; Glucose-6-Phosphatase / analysis; Glucose-6-Phosphatase / genetics; Glucose-6-Phosphatase / metabolism; Glyceraldehyde-3-Phosphate Dehydrogenases / genetics; Glycogen / analysis; Glycogen Storage Disease Type I / enzymology; Glycogen Storage Disease Type I / immunology; Glycogen Storage Disease Type I / therapy; Immunohistochemistry; Injections, Intravenous; Kidney / chemistry; Kidney / enzymology; Kidney / immunology; Liver / chemistry; Liver / enzymology; Liver / immunology; Mice; Mice, Knockout; Models, Animal; RNA, Messenger / analysis; Reverse Transcriptase Polymerase Chain Reaction; Time Factors; Transduction, Genetic / methods
TL;DR:
The development of efficacious AAV vector-mediated gene therapy could significantly reduce the impact of long-term complications in GSD-Ia, including hypoglycemia, hyperlipidemia and growth failure.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2004 journal article
The Clinician Investigator Program in Companion Animal Internal Medicine at North Carolina State University
Journal of Veterinary Medical Education, 31(4), 425–434.
MeSH headings : Animals; Animals, Domestic; Curriculum; Education, Veterinary / methods; Humans; Internal Medicine / education; Mentors; North Carolina; Research Personnel; Retrospective Studies; Schools, Veterinary; Surveys and Questionnaires
TL;DR:
A retrospective study was conducted to describe the development and evolution of the combined internal medicine/PhD program, the Clinician Investigator (CI) Program, at North Carolina State University.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: NC State University Libraries, NC State University Libraries, Crossref
Added: August 6, 2018
2003 journal article
Evaluation of the clinical and allergen specific serum immunoglobulin E responses to oral challenge with cornstarch, corn, soy and a soy hydrolysate diet in dogs with spontaneous food allergy
VETERINARY DERMATOLOGY, 14(4), 181–187.
author keywords: dog; food allergy; hydrolysed protein; IgE; intradermal test
MeSH headings : Animal Feed; Animals; Antigens; Diet; Dog Diseases / blood; Dog Diseases / diagnosis; Dog Diseases / immunology; Dogs; Female; Food Hypersensitivity / diagnosis; Food Hypersensitivity / immunology; Food Hypersensitivity / veterinary; Immunoglobulin E / blood; Immunoglobulin E / immunology; Intradermal Tests / standards; Intradermal Tests / veterinary; Male; Predictive Value of Tests; Soybean Proteins / immunology; Soybeans / immunology; Zea mays / immunology
TL;DR:
Although increases in soy and corn-specific serum IgE concentrations were measured in individual dogs post challenge they were not statistically significant and could not be used to predict clinical hypersensitivity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2003 article
Percutaneous ultrasound-guided cholecystocentesis in healthy cats
JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 17, pp. 298–303.
author keywords: bile; cholangiohepatitis; cholangitis; feline inflammatory liver disease; Helicobacter species; liver
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2002 journal article
Hypercalcemia and high parathyroid hormone-related protein concentration associated with malignant melanoma in a dog
JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 221(2), 263-+.
MeSH headings : Animals; Dog Diseases / blood; Dog Diseases / etiology; Dogs; Fatal Outcome; Hypercalcemia / etiology; Hypercalcemia / veterinary; Male; Melanoma / complications; Melanoma / metabolism; Melanoma / veterinary; Mouth Neoplasms / complications; Mouth Neoplasms / metabolism; Mouth Neoplasms / veterinary; Parathyroid Hormone-Related Protein; Proteins / metabolism
TL;DR:
A 12-year-old Cocker Spaniel with an oral malignant melanoma was evaluated for progressive lethargy and anorexia, andSerum parathyroid hormone-related protein concentration was markedly high, and the melanoma had moderate to marked immunostaining for this protein.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2001 journal article
Canine model and genomic structural organization of glycogen storage disease type Ia (GSD Ia)
VETERINARY PATHOLOGY, 38(1), 83–91.
author keywords: animal model; canine; genomic structure; glomerular sclerosis; glycogen; GSD Ia; hepatomegaly; hypoglycemia; lactic acidosis
MeSH headings : Animals; Base Sequence; Crosses, Genetic; DNA / chemistry; DNA / isolation & purification; Disease Models, Animal; Dog Diseases / blood; Dog Diseases / enzymology; Dog Diseases / genetics; Dog Diseases / pathology; Dogs; Electrophoresis, Agar Gel / veterinary; Female; Glucose-6-Phosphatase / blood; Glucose-6-Phosphatase / genetics; Glucose-6-Phosphatase / metabolism; Glycogen Storage Disease Type I / enzymology; Glycogen Storage Disease Type I / genetics; Glycogen Storage Disease Type I / pathology; Glycogen Storage Disease Type I / veterinary; Histocytochemistry / veterinary; Humans; Kidney / enzymology; Kidney / pathology; Liver / enzymology; Liver / pathology; Liver Glycogen / metabolism; Male; Microscopy, Electron / veterinary; Molecular Sequence Data; Point Mutation / genetics; Sequence Analysis, DNA
TL;DR:
Establishment of this canine colony of GSD Ia that closely resembles human disease and isolation of the canine genomic gene provides an excellent model for studying pathophysiology and long-term complications and an opportunity to develop novel therapeutic approaches such as drug and gene therapy.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2001 journal article
Secondary hypoparathyroidism attributed to hypomagnesemia in a dog with protein-losing enteropathy
JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 219(12), 1732-+.
MeSH headings : Animals; Calcium / blood; Dog Diseases / blood; Dog Diseases / etiology; Dogs; Hypoparathyroidism / etiology; Hypoparathyroidism / veterinary; Magnesium / administration & dosage; Magnesium / blood; Male; Parathyroid Hormone / blood; Paresis / veterinary; Protein-Losing Enteropathies / blood; Protein-Losing Enteropathies / complications; Protein-Losing Enteropathies / veterinary
TL;DR:
Magnesium concentration should be monitored in all dogs with gastrointestinal tract disease, especially those with protein-losing enteropathy, anorexia, and weakness.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018