Sara Dyann Lawhon

MeSH headings : Animals; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Escherichia coli Proteins / genetics; Escherichia coli Proteins / metabolism; Ethanolamine / metabolism; Filaggrin Proteins; Gene Expression Profiling; Gene Expression Regulation, Bacterial; Genome, Bacterial; Humans; Maltose / metabolism; Mutation; Oligonucleotide Array Sequence Analysis; Propylene Glycol / metabolism; RNA-Binding Proteins / genetics; RNA-Binding Proteins / metabolism; Repressor Proteins / genetics; Repressor Proteins / metabolism; Salmonella typhimurium / genetics; Salmonella typhimurium / metabolism; Salmonella typhimurium / pathogenicity; Vitamin B 12 / biosynthesis

TL;DR: Results show that csrA controls a number of gene classes in addition to those required for invasion, some of them unique to Salmonella, and suggests a co‐ordinated bacterial response to conditions that exist at the site of bacterial invasion, the intestinal tract of a host animal. (via Semantic Scholar)

MeSH headings : Animals; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Cell Line; Escherichia coli Proteins; Fatty Acids / pharmacology; Female; Gene Expression Regulation, Bacterial; Humans; Intestines / chemistry; Membrane Proteins / genetics; Membrane Proteins / metabolism; Mice; Mice, Inbred BALB C; Phosphotransferases; Salmonella Infections, Animal / microbiology; Salmonella typhimurium / genetics; Salmonella typhimurium / pathogenicity; Sepsis / microbiology; Trans-Activators / genetics; Trans-Activators / metabolism; Virulence / genetics

TL;DR: The results suggest that the concentration and composition of SCFAs in the distal ileum provide a signal for productive infection by Salmonella, whereas those of the large intestine inhibit invasion. (via Semantic Scholar)

MeSH headings : Bacterial Proteins / genetics; Bacterial Proteins / physiology; Base Sequence; Escherichia coli Proteins; Gene Expression Regulation, Bacterial; Humans; Molecular Sequence Data; RNA-Binding Proteins / physiology; Repressor Proteins; Salmonella typhimurium / genetics; Salmonella typhimurium / pathogenicity; Trans-Activators / genetics

TL;DR: It is reported here that epithelial cell invasion requires the serovar Typhimurium homologue of Escherichia coli csrA, which encodes a regulator that alters the stability of specific mRNA targets, and it is found that CsrA affected hilA, a regulator of the other three genes the authors tested, probably by controlling one or more genetic elements that regulate hILA. (via Semantic Scholar)