Amin Usmani

Works (15)

Updated: July 5th, 2023 16:01

2006 article

Inhibition of the human liver microsomal and human cytochrome P450 1A2 and 3A4 metabolism of estradiol by deployment-related and other chemicals

Usmani, K. A., Cho, T. M., Rose, R. L., & Hodgson, E. (2006, September). DRUG METABOLISM AND DISPOSITION, Vol. 34, pp. 1606–1614.

By: K. Usmani*, T. Cho, R. Rose* & E. Hodgson n

MeSH headings : Carbaryl / toxicity; Chlorpyrifos / toxicity; Cholinesterase Inhibitors / toxicity; Cytochrome P-450 CYP1A2 / genetics; Cytochrome P-450 CYP1A2 / metabolism; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System / genetics; Cytochrome P-450 Enzyme System / metabolism; Dose-Response Relationship, Drug; Estradiol / analogs & derivatives; Estradiol / metabolism; Female; Fonofos / toxicity; Humans; In Vitro Techniques; Kinetics; Liver / drug effects; Liver / enzymology; Male; Microsomes, Liver; Military Medicine; Recombinant Proteins / antagonists & inhibitors; Recombinant Proteins / metabolism
TL;DR: Phenotyped HLM use showed that individuals with high levels of CYP1A2 and CYP3A4 have the greatest potential to metabolize E2, and chlorpyrifos inhibition of E2 metabolism is shown to be irreversible. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2005 journal article

Pesticide metabolism in humans, including polymorphisms

Scandinavian Journal of Work, Environment & Health, 31, 156–163.

By: R. Rose, J. Tang, J. Choi, Y. Cao, A. Usmani, N. Cherrington, E. Hodgson

Source: NC State University Libraries
Added: August 6, 2018

2004 journal article

In vitro metabolism of carbofuran by human, mouse, and rat cytochrome P450 and interactions with chlorpyrifos, testosterone, and estradiol

CHEMICO-BIOLOGICAL INTERACTIONS, 150(3), 221–232.

By: K. Usmani n, E. Hodgson n & R. Rose n

author keywords: carbofuran; metabolism; human liver microsomes; cytochrome P450; CYP3MA4; testosterone; interactions
MeSH headings : Animals; Carbofuran / metabolism; Carbofuran / pharmacology; Chlorpyrifos / metabolism; Chlorpyrifos / pharmacology; Cytochrome P-450 Enzyme System / chemistry; Cytochrome P-450 Enzyme System / metabolism; Drug Interactions / physiology; Estradiol / metabolism; Estradiol / pharmacology; Humans; In Vitro Techniques; Isoenzymes / metabolism; Ketoconazole / pharmacology; Liver / cytology; Liver / enzymology; Mice; Microsomes, Liver / enzymology; Pesticides / metabolism; Rats; Testosterone / metabolism; Testosterone / pharmacology
TL;DR: Investigating the comparative in vitro metabolism of carbofuran from human, rat, and mouse liver microsomes and characterize the specific enzymes involved in such metabolism found that individuals with high levels of CYP3A4 have the greatest potential to metabolize carb ofuran to its major metabolite. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2004 journal article

In vitro metabolism of fipronil by human and rat cytochrome P450 and its interactions with testosterone and diazepam

CHEMICO-BIOLOGICAL INTERACTIONS, 147(3), 319–329.

By: J. Tang n, K. Usmani n, E. Hodgson n & R. Rose n

author keywords: fipronil; metabolism; human liver microsomes; cytochrome p450; CYP3A4; interaction
MeSH headings : Animals; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System / metabolism; Diazepam / metabolism; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Enzyme Inhibitors / pharmacology; Humans; Insecticides / metabolism; Isoenzymes / metabolism; Ketoconazole / pharmacology; Microsomes, Liver / enzymology; Pyrazoles / metabolism; Rats; Species Specificity; Testosterone / metabolism
TL;DR: The results suggest that fipronil has the potential to interact with a wide range of xenobiotics or endogenous chemicals that are CYP3A4 substrates and that fIPronil may be a useful substrate for the characterization of CYP 3A4 in HLM. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2004 journal article

In vitro sulfoxidation of thioether compounds by human cytochrome P450 and flavin-containing monooxygenase isoforms with particular reference to the CYP2C subfamily

DRUG METABOLISM AND DISPOSITION, 32(3), 333–339.

By: K. Usmani n, E. Karoly*, E. Hodgson* & R. Rose*

MeSH headings : Aryl Hydrocarbon Hydroxylases / antagonists & inhibitors; Catalysis; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 Enzyme System / metabolism; Enzyme Inhibitors / pharmacology; Humans; In Vitro Techniques; Isoenzymes / metabolism; Microsomes, Liver / drug effects; Microsomes, Liver / enzymology; Mixed Function Oxygenases / antagonists & inhibitors; Monoamine Oxidase / metabolism; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Sulfaphenazole / pharmacology; Sulfides / metabolism; Sulfoxides / metabolism; Ticlopidine / pharmacology
TL;DR: The results indicate that current models of the substrate binding site of the CYP2C subfamily would not effectively predict thioether pesticide metabolism, and the substrate specificity of CYP 2Cs is more extensive than is currently believed, and some reevaluation of structure-activity relationships may be required. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2003 journal article

Genetic findings and functional studies of human CYP3A5 single nucleotide polymorphisms in different ethnic groups

Pharmacogenetics, 13(8), 461–472.

By: S. Lee, K. Usmani, B. Chanas, B. Ghanayem, H. T., M. E., . H. W., J. Goldstein

Source: NC State University Libraries
Added: August 6, 2018

2003 journal article

Inhibition and activation of the human liver microsomal and human cytochrome P450 3A4 metabolism of testosterone by deployment-related chemicals

DRUG METABOLISM AND DISPOSITION, 31(4), 384–391.

By: K. Usmani n, R. Rose* & E. Hodgson*

MeSH headings : Chlorpyrifos / pharmacology; Cholinesterase Inhibitors / pharmacology; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System / metabolism; Dose-Response Relationship, Drug; Gonadal Steroid Hormones / metabolism; Humans; In Vitro Techniques; Isoenzymes / metabolism; Kinetics; Microsomes, Liver / drug effects; Microsomes, Liver / metabolism; Steroid Hydroxylases / metabolism; Testosterone / metabolism
TL;DR: Kinetic analysis indicated that chlorpyrifos was one of the most potent inhibitors of major TST metabolites followed by fonofos and phorate, and inhibited major T ST metabolites noncompetitively and irreversibly. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2002 journal article

In vitro human metabolism and interactions of repellent N,N-diethyl-M-toluamide

DRUG METABOLISM AND DISPOSITION, 30(3), 289–294.

By: K. Usmani n, R. Rose*, J. Goldstein*, W. Taylor, A. Brimfield & E. Hodgson*

MeSH headings : Animals; Biotransformation; Chlorpyrifos / metabolism; Chlorpyrifos / pharmacology; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System / biosynthesis; Cytochrome P-450 Enzyme System / genetics; Cytochrome P-450 Enzyme System / metabolism; DEET / analogs & derivatives; DEET / metabolism; DEET / pharmacokinetics; Drug Interactions; Enzyme Induction / drug effects; Enzyme Inhibitors / metabolism; Enzyme Inhibitors / pharmacology; Female; Humans; In Vitro Techniques; Insect Repellents / metabolism; Insect Repellents / pharmacokinetics; Isoenzymes / biosynthesis; Isoenzymes / genetics; Isoenzymes / metabolism; Male; Mice; Microsomes, Liver / enzymology; Oxidation-Reduction; Permethrin / metabolism; Permethrin / pharmacology; Pyridostigmine Bromide / metabolism; Pyridostigmine Bromide / pharmacology; Rats; Rats, Long-Evans; Spectrometry, Fluorescence
TL;DR: Use of phenotyped HLMs demonstrated that individuals with high levels of CYP2B6, 3A4, 2C19, and 2A6 have the greatest potential to metabolize DEET. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2001 journal article

DEF sensitive esterases in homogenates of larval and adult Helicoverpa zea, Spodoptera frugiperda, and Agrotis ipsilon (Lepidoptera : Noctuidae)

JOURNAL OF ECONOMIC ENTOMOLOGY, 94(4), 884–891.

By: K. Usmani* & C. Knowles*

author keywords: noctuidae; esterases; inhibition studies; S,S,S-tri-n-butyl phosphorotrithioate
MeSH headings : Animals; Esterases / antagonists & inhibitors; Esterases / isolation & purification; Esterases / metabolism; Female; Insecticides / metabolism; Larva / enzymology; Male; Moths / enzymology; Naphthols / metabolism; Organothiophosphates / pharmacology; Pesticide Synergists / pharmacology; Pyrethrins / metabolism; Spodoptera / enzymology
TL;DR: Homogenates of Helicoverpa zea, Agrotis ipsilon, and Spodoptera frugiperda third instars and adults contained S,S,S-tri-n-butyl phosphorotrithioate (DEF)-sensitive enzymes that hydrolyzed trans-cypermethrin and two known esterase substrates, α-naphthyl acetate and β- naphthy acetate. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2001 journal article

Pharmacokinetic mechanisms associated with synergism by DEF of cypermethrin toxicity in larval and adult Helicoverpa zea, Spodoptera frugiperda, and Agrotis ipsilon (Lepidoptera : Noctuidae)

JOURNAL OF ECONOMIC ENTOMOLOGY, 94(4), 874–883.

By: K. Usmani* & C. Knowles*

author keywords: Noctuidae; cypermethrin; pharmacokinetics; S,S,S-tri-n-butyl phosphorotrithioate; synergism
MeSH headings : Animals; Insecticides / metabolism; Insecticides / pharmacokinetics; Insecticides / toxicity; Larva / drug effects; Larva / metabolism; Moths / drug effects; Moths / metabolism; Organothiophosphates / metabolism; Organothiophosphates / pharmacokinetics; Pesticide Synergists / metabolism; Pesticide Synergists / pharmacokinetics; Pyrethrins / metabolism; Pyrethrins / pharmacokinetics; Pyrethrins / toxicity; Spodoptera / drug effects; Spodoptera / metabolism
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2001 journal article

Sex-related response to organophosphorus and carbamate insecticides in adult Oriental fruit moth, Grapholita molesta

PEST MANAGEMENT SCIENCE, 57(9), 822–826.

By: P. Shearer* & K. Usmani n

author keywords: insecta; insecticide resistance; resistance monitoring; treatment thresholds; sex-linked; insecticide
MeSH headings : Animals; Carbamates; Female; Insect Control / methods; Insecticide Resistance; Insecticides / toxicity; Larva / drug effects; Male; Moths / drug effects; Organothiophosphorus Compounds; Sex Factors
TL;DR: Concerns are raised regarding the use of pheromone traps for determining whether insecticide treatments are required and as part of resistance monitoring programs after preliminary results indicated that more males survived diagnostic doses of azinphos-methyl than females. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2001 journal article

Susceptibility of male Oriental fruit moth (Lepidoptera : Tortricidae) populations from New Jersey apple orchards to azinphosmethyl

JOURNAL OF ECONOMIC ENTOMOLOGY, 94(1), 233–239.

By: K. Usmani* & P. Shearer*

author keywords: Grapholita molesta; azinphosmethyl; resistance monitoring; bioassay; synergism
MeSH headings : Animals; Azinphosmethyl; Biological Assay; Insect Control / methods; Insecticides; Male; Moths; New Jersey; Pheromones; Rosales
TL;DR: S,S, S,S,-tri-n-butyl phosphorotrithioate (DEF), but not piperonyl butoxide, significantly enhanced the toxicity of azinphosmethyl, suggesting that enhanced metabolism by esterases is involved in the tolerance in moths collected from these study sties. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
15. Life on Land (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2001 journal article

Toxicity of pyrethroids and effect of synergists to larval and adult Helicoverpa zea, Spodoptera frugiperda, and Agrotis ipsilon (Lepidoptera : Noctuidae)

JOURNAL OF ECONOMIC ENTOMOLOGY, 94(4), 868–873.

By: K. Usmani* & C. Knowles*

author keywords: Noctuidae; cypermethrin; permethrin; toxicity; synergism
MeSH headings : Animals; Biological Assay; Female; Insecticides / toxicity; Larva; Male; Moths / drug effects; Organothiophosphates / pharmacology; Permethrin / toxicity; Pesticide Synergists / pharmacology; Piperonyl Butoxide / pharmacology; Pyrethrins / toxicity; Spodoptera / drug effects; Toluidines / pharmacology
TL;DR: Based on 48 h LD50 estimates from topical bioassays, cypermethrin was more toxic than permethrin to Helicoverpa zea (Boddie) larvae and adults; however, the two pyrethroids did not differ significantly in their relative toxicities to Spodoptera frugiperda and Agrotis ipsilon. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2000 journal article

Azinphosmethyl resistance in populations of male Oriental fruit moth (Lepidoptera: Tortricidae) from New Jersey apple orchards

Resistant Pest Management, 11(1), 8.

By: K. Usmani & P. Shearer

Source: NC State University Libraries
Added: August 6, 2018

2000 journal article

Cypermethrin pharmacokinetics in laboratory and field strains of Helicoverpa zea (Lepidoptera: Noctuidae)

Resistant Pest Management, 11(1), 13.

By: K. Usmani & C. Knowles

Source: NC State University Libraries
Added: August 6, 2018

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