Works (8)
Updated: July 5th, 2023 16:00
2004 journal article
B7(+)CTLA4(+) T cells engage in T-T cell interactions that mediate apoptosis: a model for lentivirus-induced T cell depletion
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 98(3-4), 203–214.
author keywords: FIV; apoptosis; 137 costimulatory molecules; CTLA4
MeSH headings : Animals; Antigens, CD / biosynthesis; Antigens, CD / immunology; Antigens, Differentiation / biosynthesis; Antigens, Differentiation / immunology; Apoptosis / immunology; B7-1 Antigen / biosynthesis; B7-1 Antigen / immunology; B7-2 Antigen; CTLA-4 Antigen; Cats; Cell Communication / immunology; Concanavalin A / immunology; Feline Acquired Immunodeficiency Syndrome / immunology; Flow Cytometry / veterinary; Immunodeficiency Virus, Feline / immunology; In Situ Nick-End Labeling / veterinary; Ionomycin / immunology; Lymphocyte Activation / immunology; Membrane Glycoproteins / biosynthesis; Membrane Glycoproteins / immunology; Specific Pathogen-Free Organisms; T-Lymphocytes / immunology; T-Lymphocytes / virology; Tetradecanoylphorbol Acetate / immunology
TL;DR:
The hypothesis that the chronic expansion of B7+CTLA4+ LN T cells in infected cats allows for T-T cell interactions resulting in T cell depletion and eventually the development of AIDS is supported.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2004 journal article
Spontaneous T cell apoptosis in feline immunodeficiency virus (FIV)-infected cats is inhibited by IL2 and anti-B7.1 antibodies
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 99(1-2), 25–37.
author keywords: FIV; apoptosis; IL2; B7 co-stimulatory molecules; CTLA4
MeSH headings : Animals; Antibodies, Blocking / immunology; Antigens, CD / immunology; Apoptosis / drug effects; Apoptosis / immunology; B7-2 Antigen; CD4-Positive T-Lymphocytes / immunology; CD4-Positive T-Lymphocytes / pathology; CD4-Positive T-Lymphocytes / virology; CD8-Positive T-Lymphocytes / immunology; CD8-Positive T-Lymphocytes / pathology; CD8-Positive T-Lymphocytes / virology; Cats; Feline Acquired Immunodeficiency Syndrome / blood; Feline Acquired Immunodeficiency Syndrome / immunology; Immunodeficiency Virus, Feline / genetics; Immunodeficiency Virus, Feline / immunology; In Situ Nick-End Labeling / veterinary; Interleukin-2 / immunology; Interleukin-2 / pharmacology; Lymph Nodes / immunology; Lymphocyte Activation / immunology; Membrane Glycoproteins / antagonists & inhibitors; Membrane Glycoproteins / immunology; RNA, Viral / chemistry; RNA, Viral / genetics; Reverse Transcriptase Polymerase Chain Reaction / veterinary; Specific Pathogen-Free Organisms
TL;DR:
A role of B7 signaling in the increased spontaneous apoptosis observed in LN T cells from FIV-infected animals is suggested.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2003 journal article
Evaluation of T lymphocytes in captive African lions (Panthera leo) infected with feline immunodeficiency virus
AMERICAN JOURNAL OF VETERINARY RESEARCH, 64(10), 1293–1300.
MeSH headings : Animals; Animals, Zoo; Antibodies, Viral / blood; CD4-Positive T-Lymphocytes / immunology; CD8-Positive T-Lymphocytes / immunology; Cats; Feline Acquired Immunodeficiency Syndrome / immunology; Female; Flow Cytometry; Immunodeficiency Virus, Feline; Lions / immunology; North Carolina; T-Lymphocytes / immunology
TL;DR:
FIV+ African lions develop lymphocyte deficiencies, including significant decreases in the absolute number of CD4+ and CD8+ T cells; these findings of immune dysfunction are similar to those defined for FIV+ domestic cats.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2002 article
Feline immunodeficiency virus infection is characterized by B7(+)CTLA4(+) T cell apoptosis
Tompkins, M. B., Bull, M. E., Dow, J. L., Ball, J. M., Collisson, E. W., Winslow, B. J., … Tompkins, W. A. (2002, April 15). JOURNAL OF INFECTIOUS DISEASES, Vol. 185, pp. 1077–1093.
MeSH headings : Abatacept; Animals; Antigens, CD / analysis; Antigens, Differentiation / analysis; Apoptosis; B7-1 Antigen / analysis; B7-2 Antigen; CTLA-4 Antigen; Cats; Feline Acquired Immunodeficiency Syndrome / immunology; Immunoconjugates; In Situ Nick-End Labeling; Membrane Glycoproteins / analysis; T-Lymphocytes / physiology
TL;DR:
Data support the hypothesis that lymph node apoptosis and immune deterioration in FIV-infected cats results from chronic B7.1- and/or B.2-CTLA4-mediated T-T interactions.
(via Semantic Scholar)
academic.oup.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2002 journal article
Polymorphic expression in the CD8 alpha chain surface receptor of African lions (Panthera leo)
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 84(3-4), 181–189.
author keywords: African lion (Panthera leo); monoclonal antibody; cross-reactivity; CD8 alpha polymorphism
MeSH headings : Africa, Southern; Animals; Antibodies, Monoclonal; Antibody Specificity; Cats; Cross Reactions; Epitopes; Lions / genetics; Lions / immunology; Polymorphism, Genetic; Receptors, Antigen, T-Cell / chemistry; Receptors, Antigen, T-Cell / genetics; Species Specificity
TL;DR:
Free-ranging African lion peripheral blood mononuclear cells were examined to determine if phenotypic changes occurred in lion lymphocytes as a result of feline immunodeficiency virus (FIV) infection and suggests that lions similar to other mammalian species demonstrate polymorphic expression of the CD8alpha chain.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2001 conference paper
B7.1/B7.2 and CTLA4 expression on feline T cells in vitro correlates with apoptosis
Journal of Leukocyte Biology, (2001), 255.
Source: NC State University Libraries
Added: August 6, 2018
2001 conference paper
Feline immunodeficiency virus (FIV) infection induces B7(+)CTLA4(+) T cell apoptosis: A model for T cell depletion and immunodeficiency
Journal of Leukocyte Biology, (2001), 254.
Source: NC State University Libraries
Added: August 6, 2018
2001 conference paper
T cell apoptosis in FIV-infected cats is blocked by the addition of antibodies to B7.1 and B7.2
Journal of Leukocyte Biology, (2001), 256.
Source: NC State University Libraries
Added: August 6, 2018
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