Works (8)
Updated: July 5th, 2023 16:00
2005 journal article
Effects of cyclooxygenase inhibitors flunixin and deracoxib on permeability of ischaemic-injured equine jejunum
EQUINE VETERINARY JOURNAL, 37(1), 75–80.
author keywords: horse; intestine; nonsteroidal anti-inflammatory; flunixin; deracoxib
MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / pharmacology; Biological Transport; Clonixin / analogs & derivatives; Clonixin / pharmacology; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors / pharmacology; Electric Impedance; Histological Techniques; Horse Diseases / drug therapy; Horses; Intestinal Mucosa / blood supply; Intestinal Mucosa / drug effects; Ischemia / drug therapy; Ischemia / veterinary; Jejunum / blood supply; Jejunum / drug effects; Jejunum / metabolism; Mannitol / metabolism; Misoprostol / pharmacology; Permeability / drug effects; Prostaglandin-Endoperoxide Synthases / metabolism; Prostaglandins / metabolism; Reperfusion / veterinary; Sulfonamides / pharmacology; Tritium
TL;DR:
Treatment of horses with ischaemic jejunal disease with flunixin may result in a prolonged permeability defect in recovering mucosa, which may have implications for the use of nonsteroidal anti-inflammatory drugs in colic patients.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2005 article
Post operative neutrophilic inflammation in equine small intestine after manipulation and ischaemia
Little, D., Tomlinson, J. E., & Blikslager, A. T. (2005, July). EQUINE VETERINARY JOURNAL, Vol. 37, pp. 329–335.
MeSH headings : Analysis of Variance; Animals; Horse Diseases / immunology; Horses; Ileus / immunology; Ileus / veterinary; Immunohistochemistry / veterinary; Ischemia / immunology; Ischemia / veterinary; Jejunum / blood supply; Jejunum / pathology; Leukocyte L1 Antigen Complex / metabolism; Neutrophil Infiltration; Neutrophils / metabolism; Neutrophils / physiology; Postoperative Complications / immunology; Postoperative Complications / veterinary; Postoperative Period; Random Allocation
TL;DR:
This neutrophilic inflammation coincides with the clinical time point at which POI is identified and may indicate that inflammatory pathways, rather than solely neurogenic pathways, are responsible for POI in the horse.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2004 journal article
Effects of flunixin meglumine or etodolac treatment on mucosal recovery of equine jejunum after ischemia
AMERICAN JOURNAL OF VETERINARY RESEARCH, 65(6), 761–769.
Contributors: n, O. Wilder n, K. Young n & A. Blikslager n
MeSH headings : Animals; Biological Transport; Blotting, Western; Clonixin / analogs & derivatives; Clonixin / pharmacokinetics; Clonixin / therapeutic use; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors / pharmacokinetics; Cyclooxygenase Inhibitors / therapeutic use; Eicosanoids / metabolism; Electric Impedance; Epithelium / blood supply; Etodolac / pharmacokinetics; Etodolac / therapeutic use; Gene Expression; Histological Techniques; Horse Diseases / drug therapy; Horses; Ischemia / drug therapy; Ischemia / veterinary; Isoenzymes / metabolism; Jejunum / blood supply; Mannitol; Neutrophils; Pain Measurement / veterinary; Prostaglandin-Endoperoxide Synthases / metabolism; Reperfusion / veterinary; Time Factors; Tritium
TL;DR:
Flunixin and etodolac treatment retarded recovery of intestinal barrier function in jejunal mucosa after 18 hours of reperfusion, whereas tissues from horses treated with saline solution recovered baseline values of TER and permeability to mannitol.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2004 journal article
Effects of ischemia and the cyclooxygenase inhibitor flunixin on in vitro passage of lipopolysaccharide across equine jejunum
AMERICAN JOURNAL OF VETERINARY RESEARCH, 65(10), 1377–1383.
Contributors: n & A. Blikslager*
MeSH headings : Acute-Phase Proteins / metabolism; Analysis of Variance; Animals; Biological Transport / drug effects; Blotting, Western / veterinary; Carrier Proteins / metabolism; Clonixin / analogs & derivatives; Clonixin / pharmacology; Electrophoresis, Polyacrylamide Gel / veterinary; Fluorescence; Horse Diseases / metabolism; Horses; In Vitro Techniques; Ischemia / metabolism; Ischemia / veterinary; Jejunum / blood supply; Jejunum / drug effects; Jejunum / metabolism; Lipopolysaccharides / metabolism; Membrane Glycoproteins / metabolism; Time Factors; Tumor Necrosis Factor-alpha / metabolism
TL;DR:
Evaluated the clinical importance of flunixin-associated delayed mucosal recovery requires further in vivo investigation, and ischemia increased LPS passage across equine jejunal mucosa.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2004 journal article
Interactions between lipopolysaccharide and the intestinal epithelium
JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 224(9), 1446–1452.
Contributors: n & A. Blikslager*
MeSH headings : Animals; Chemotaxis; Endotoxemia / microbiology; Endotoxemia / physiopathology; Endotoxemia / veterinary; Epithelial Cells / metabolism; Epithelial Cells / microbiology; Intestinal Mucosa / immunology; Intestinal Mucosa / metabolism; Intestinal Mucosa / microbiology; Lipopolysaccharides / chemistry; Lipopolysaccharides / metabolism
TL;DR:
Endotoxemia is a result of absorption of lipopolysaccharide from intestinal gram-negative bacteria, and small amounts of LPS may be found in the portal blood of healthy individuals.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2003 journal article
Computed tomographic anatomy of the equine tarsus
VETERINARY RADIOLOGY & ULTRASOUND, 44(2), 174–178.
author keywords: horse; tarsus; anatomy; computed tomography
MeSH headings : Animals; Ankle / anatomy & histology; Ankle / diagnostic imaging; Horses / anatomy & histology; Tomography, X-Ray Computed
TL;DR:
CT examinations of the tarsal regions from four clinically and radiographically normal adult horses, which were euthanized for reasons not related to musculoskeletal disease, were included in the study.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2003 journal article
Ultrasonographic abnormalities detected in the sacroiliac area in twenty cases of upper hindlimb lameness
EQUINE VETERINARY JOURNAL, 35(1), 48–54.
author keywords: horse; ultrasound; sacroiliac; ligament; fracture
MeSH headings : Animals; Female; Hindlimb; Horse Diseases / diagnosis; Horse Diseases / diagnostic imaging; Horses / anatomy & histology; Horses / injuries; Lameness, Animal / diagnosis; Lameness, Animal / diagnostic imaging; Lameness, Animal / etiology; Ligaments / diagnostic imaging; Ligaments / injuries; Low Back Pain / diagnostic imaging; Low Back Pain / etiology; Low Back Pain / veterinary; Male; Sacrococcygeal Region / diagnostic imaging; Sacroiliac Joint / anatomy & histology; Sacroiliac Joint / diagnostic imaging; Sacroiliac Joint / injuries; Ultrasonography
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2001 journal article
Detailed ultrasonographic mapping of the pelvis in clinically normal horses and ponies
AMERICAN JOURNAL OF VETERINARY RESEARCH, 62(11), 1768–1775.
MeSH headings : Animals; Horses / anatomy & histology; Magnetic Resonance Imaging / veterinary; Pelvis / anatomy & histology; Pelvis / diagnostic imaging; Pilot Projects; Tomography, X-Ray Computed / veterinary; Ultrasonography
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
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