Works (28)

2020 journal article

DRoP: Automated detection of conserved solvent-binding sites on proteins

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 88(1), 152–165.

By: B. Kearney n, M. Schwabe*, K. Marcus*, D. Roberts n, M. Dechene, P. Swartz, C. Mattos

author keywords: conserved solvent positions; DRoP software; protein hydration; protein multiple crystal structures; RNase A; water analysis program
Source: Web Of Science
Added: August 12, 2019

2020 article

Exploring the Rap1A Active Site Through Accelerated Molecular Dynamic Simulations

Schwabe, M., Holzapfel, G., & Mattos, C. (2020, April). FASEB JOURNAL, Vol. 34.

By: M. Schwabe*, G. Holzapfel & C. Mattos

Source: Web Of Science
Added: October 12, 2020

2019 journal article

Titration of ionizable groups in proteins using multiple neutron data sets from a single crystal: application to the small GTPase Ras

ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 75(2), 111–115.

By: R. Knihtila*, A. Volmar*, F. Meilleur & C. Mattos

author keywords: in crystallo titration; neutron crystallography; pK(a); protonation; radiation damage
Sources: Web Of Science, ORCID
Added: February 18, 2019

2018 journal article

Neutron scattering in the biological sciences: progress and prospects

ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, 74, 1129–1168.

author keywords: neutron scattering; biological systems; structure and dynamics
Sources: Web Of Science, ORCID
Added: January 21, 2019

2015 journal article

Allosteric Effects of the Oncogenic RasQ61L Mutant on Raf-RBD

STRUCTURE, 23(3), 505–516.

By: S. Fetics, H. Guterres*, B. Kearney n, G. Buhrman, B. Ma*, R. Nussinov*, C. Mattos

Source: Web Of Science
Added: August 6, 2018

2015 journal article

Neutron Crystal Structure of RAS GTPase Puts in Question the Protonation State of the GTP gamma-Phosphate

JOURNAL OF BIOLOGICAL CHEMISTRY, 290(52), 31025–31036.

By: R. Knihtila*, G. Holzapfel, K. Weiss*, F. Meilleur & C. Mattos

Sources: Web Of Science, ORCID
Added: August 6, 2018

2014 journal article

DRoP: A Water Analysis Program Identifies Ras-GTP-Specific Pathway of Communication between Membrane-Interacting Regions and the Active Site

JOURNAL OF MOLECULAR BIOLOGY, 426(3), 611–629.

By: B. Kearney n, C. Johnson*, D. Roberts n, P. Swartz & C. Mattos

author keywords: crystallographic water analysis; Ras GTPase; water-mediated networks in protein structure; protein hydration; DRoP software
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Allosteric modulation of caspase 3 through mutagenesis

BIOSCIENCE REPORTS, 32(4), 401–411.

author keywords: allosteric site; apoptosis; caspase; inhibition; protein ensemble
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Shift in the Equilibrium between On and Off States of the Allosteric Switch in Ras-GppNHp Affected by Small Molecules and Bulk Solvent Composition

BIOCHEMISTRY, 51(31), 6114–6126.

By: G. Holzapfel, G. Buhrman & C. Mattos

Source: Web Of Science
Added: August 6, 2018

2012 journal article

Structurally Conserved Nop56/58 N-terminal Domain Facilitates Archaeal Box C/D Ribonucleoprotein-guided Methyltransferase Activity

JOURNAL OF BIOLOGICAL CHEMISTRY, 287(23), 19418–19428.

By: K. Gagnon, S. Biswas, X. Zhang, B. Brown n, P. Wollenzien, C. Mattos, E. Maxwell n

Source: Web Of Science
Added: August 6, 2018

2011 journal article

Allosteric Modulation of Ras-GTP Is Linked to Signal Transduction through RAF Kinase

JOURNAL OF BIOLOGICAL CHEMISTRY, 286(5), 3323–3331.

By: G. Buhrman, V. Kumar*, M. Cirit, J. Haugh & C. Mattos

Sources: Web Of Science, ORCID
Added: August 6, 2018

2011 journal article

Comparative Analysis of the 15.5kD Box C/D snoRNP Core Protein in the Primitive Eukaryote Giardia lamblia Reveals Unique Structural and Functional Features

BIOCHEMISTRY, 50(14), 2907–2918.

By: S. Biswas, G. Buhrman, K. Gagnon*, C. Mattos, B. Brown n & E. Maxwell n

Source: Web Of Science
Added: August 6, 2018

2011 journal article

Thermodynamic, enzymatic and structural effects of removing a salt bridge at the base of loop 4 in (pro)caspase-3

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 508(1), 31–38.

By: J. Walters, P. Swartz, C. Mattos & A. Clark

author keywords: Apoptosis; Caspase activation; Enzyme activity; Protein folding and assembly
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Allosteric modulation of Ras positions Q61 for a direct role in catalysis

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 107(11), 4931–4936.

By: G. Buhrman, G. Holzapfel, S. Fetics & C. Mattos

author keywords: GTPase; Raf; calcium; intrinsic hydrolysis
Source: Web Of Science
Added: August 6, 2018

2009 journal article

A constitutively active and uninhibitable caspase-3 zymogen efficiently induces apoptosis

BIOCHEMICAL JOURNAL, 424, 335–345.

author keywords: apoptosis; cancer therapy; conformational switch; co-operative dimer interface; procaspase activation
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Fragment-based identification of druggable 'hot spots' of proteins using Fourier domain correlation techniques

BIOINFORMATICS, 25(5), 621–627.

By: R. Brenke*, D. Kozakov n, G. Chuang n, D. Beglov n, D. Hall n, M. Landon n, C. Mattos, S. Vajda n

Source: Web Of Science
Added: August 6, 2018

2009 journal article

Multiple solvent crystal structures of ribonuclease A: An assessment of the method

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 76(4), 861–881.

By: M. Dechene, G. Wink, M. Smith, P. Swartz & C. Mattos

author keywords: organic solvents; solvent mapping; plasticity; hydration; protein binding sites
Source: Web Of Science
Added: August 6, 2018

2008 review

Minimizing frustration by folding in an aqueous environment

[Review of ]. Archives of Biochemistry and Biophysics, 469(1), 118–131.

By: C. Mattos & A. Clark

Source: NC State University Libraries
Added: August 6, 2018

2007 journal article

Rapid folding and unfolding of Apaf-1 CARD

JOURNAL OF MOLECULAR BIOLOGY, 369(1), 290–304.

By: S. Milam, N. Nicely, B. Feeney, C. Mattos & A. Clark

author keywords: caspase recruitment domain; protein folding; folding kinetics; parallel folding channels; sequential mixing stopped-flow
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Transformation efficiency of RasQ61 mutants linked to structural features of the switch regions in the presence of Raf

STRUCTURE, 15(12), 1618–1629.

By: G. Buhrman, G. Wink & C. Mattos

Source: Web Of Science
Added: August 6, 2018

2006 journal article

Multiple solvent crystal structures: Probing binding sites, plasticity and hydration

JOURNAL OF MOLECULAR BIOLOGY, 357(5), 1471–1482.

By: C. Mattos, C. Bellamacina*, E. Peisach*, A. Pereira*, D. Vitkup*, G. Petsko*, D. Ringe*

author keywords: elastase; solvent mapping; organic solvents; protein binding sites; multiple solvent crystal structures
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Role of loop bundle hydrogen bonds in the maturation and activity of (pro) caspase-3

BIOCHEMISTRY, 45(44), 13249–13263.

By: B. Feeney, C. Pop n, P. Swartz, C. Mattos & A. Clark

Source: Web Of Science
Added: August 6, 2018

2005 journal article

Structural mechanism of oxidative regulation of the phosphatase Cdc25B via an intramolecular disulfide bond

BIOCHEMISTRY, 44(14), 5307–5316.

Source: Web Of Science
Added: August 6, 2018

2004 journal article

Crystal structures of Ral-GppNHp and Ral-GDP reveal two binding sites that are also present in Ras and Rap

STRUCTURE, 12(11), 2025–2036.

By: N. Nicely, J. Kosak, V. Serrano n & C. Mattos

Source: Web Of Science
Added: August 6, 2018

2004 journal article

X-ray structural and simulation analysis of a protein mutant: The value of a combined approach

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 55(3), 733–742.

By: C. Mattos, J. Cohen*, D. Green*, B. Tidor* & M. Karplus*

Source: Web Of Science
Added: August 6, 2018

2003 journal article

Organic solvents order the dynamic switch II in Ras crystals

STRUCTURE, 11(7), 747–751.

By: G. Buhrman, V. Serrano n & C. Mattos

Source: Web Of Science
Added: August 6, 2018

2002 review

Protein-water interactions in a dynamic world

[Review of ]. Trends in Biochemical Sciences, 27(4), 203–208.

By: C. Mattos

Source: NC State University Libraries
Added: August 6, 2018

2001 journal article

Proteins in organic solvents

CURRENT OPINION IN STRUCTURAL BIOLOGY, 11(6), 761–764.

By: C. Mattos & D. Ringe*

Source: Web Of Science
Added: August 6, 2018