Works (4)

Updated: July 5th, 2023 16:03

2001 journal article

Lung-specific mutagenicity and mutational spectrum in B6C3F1 lacI transgenic mice following inhalation exposure to 1,2-epoxybutene


By: C. Saranko n, K. Meyer*, L. Pluta*, R. Henderson* & L. Recio*

author keywords: lung-specific mutagenicity; mutational spectrum; B6C3F1 lacI transgenic mice
MeSH headings : Administration, Inhalation; Animals; Bacterial Proteins / drug effects; Bacterial Proteins / genetics; Bone Marrow / metabolism; DNA Mutational Analysis; Epoxy Compounds / administration & dosage; Epoxy Compounds / toxicity; Escherichia coli Proteins; Female; Lac Repressors; Lung / metabolism; Mice; Mice, Transgenic; Mutagenesis / drug effects; Mutagenesis / genetics; Mutagens / administration & dosage; Mutagens / toxicity; Repressor Proteins / drug effects; Repressor Proteins / genetics; Spleen / metabolism; Tissue Distribution
TL;DR: It is hypothesized that the direct in vivo mutagenicity and further in situ metabolism of EB in the lungs of EB-exposed mice played a prominent role in the generation of the current mutational spectrum. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1999 journal article

Expression and distribution of cytochrome P450 2E1 in B6C3F1 mouse liver and testes


By: L. Healy n, L. Pluta* & L. Recio*

author keywords: cytochrome P450 2E1; testes; liver; B6C3F1 mouse; immunohistochemistry
MeSH headings : Animals; Blotting, Western; Cytochrome P-450 CYP2E1 / genetics; Cytochrome P-450 CYP2E1 / metabolism; DNA / analysis; DNA Primers / chemistry; Electrophoresis, Agar Gel; Immunoenzyme Techniques; Liver / chemistry; Liver / enzymology; Male; Mice; Mice, Inbred Strains; Reverse Transcriptase Polymerase Chain Reaction; Sequence Analysis, DNA; Testis / chemistry; Testis / enzymology; Tissue Distribution
TL;DR: Results suggest that in situ bioactivation of BD in testes by CYP2E1 may contribute to BD-induced germ cell genotoxicity. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1998 journal article

Butadiene metabolite, 1,2:3,4-diepoxybutane, induces micronuclei but is only weekly mutagenic at lacI in the Big Blue(R) Rat2 lacI transgenic cell line

Environmental and Molecular Mutagenesis, 31(1), 32–40.

By: C. Saranko & L. Recio

Source: NC State University Libraries
Added: August 6, 2018

1998 journal article

Molecular analysis of lacI mutants from transgenic fibroblasts exposed to 1,2-epoxybutene

CARCINOGENESIS, 19(11), 1879–1887.

By: C. Saranko n, L. Pluta & L. Recio

MeSH headings : Animals; Bacterial Proteins / genetics; Epoxy Compounds / toxicity; Escherichia coli Proteins; Fibroblasts; Lac Repressors; Mice; Mutagens / toxicity; Mutation; Rats; Repressor Proteins / genetics; Transfection
TL;DR: The mutagenicity and mutational spectrum of EB in Rat2 lacI transgenic fibroblasts are determined and suggest that EB causes mutation primarily by base substitution and that the spectrum of these mutations closely resembles that of BD. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

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