Thomas W. Vahlenkamp

Works (16)

Updated: July 5th, 2023 16:00

2014 journal article

Antiviral efficacy of nine nucleoside reverse transcriptase inhibitors against feline immunodeficiency virus in feline peripheral blood mononuclear cells

AMERICAN JOURNAL OF VETERINARY RESEARCH, 75(3), 273–281.

By: A. Schwartz*, M. McCrackin, R. Schinazi, P. Hill, T. Vahlenkamp*, M. Tompkins*, K. Hartmann

MeSH headings : Animals; Antiviral Agents / pharmacology; Cats; Cell Line; Immunodeficiency Virus, Feline / drug effects; Leukocytes, Mononuclear / drug effects; Leukocytes, Mononuclear / virology; Reverse Transcriptase Inhibitors / pharmacology
TL;DR: The evaluated NRTIs had low cytotoxicity against feline peripheral blood mononuclear cells and appeared to be safe options for further in vivo evaluation for the treatment of FIV-infected cats. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2006 journal article

Cerebrospinal fluid is an efficient route for establishing brain infection with feline immunodeficiency virus and transfering infectious virus to the periphery

JOURNAL OF NEUROVIROLOGY, 12(4), 294–306.

By: P. Liu n, L. Hudson n, M. Tompkins n, T. Vahlenkamp n, B. Colby n, C. Rundle*, R. Meeker *

author keywords: dementia; HIV; macrophages; T cells; viremia
MeSH headings : Animals; Brain Diseases / cerebrospinal fluid; Brain Diseases / immunology; Brain Diseases / virology; Cats; DNA, Viral / isolation & purification; Feline Acquired Immunodeficiency Syndrome / cerebrospinal fluid; Feline Acquired Immunodeficiency Syndrome / immunology; Feline Acquired Immunodeficiency Syndrome / virology; Immunodeficiency Virus, Feline / genetics; Immunodeficiency Virus, Feline / isolation & purification; Lymphocyte Subsets / immunology; Macrophages / immunology; Macrophages / virology; RNA, Viral / blood; RNA, Viral / cerebrospinal fluid; Viral Load
TL;DR: Results indicate that free FIV circulating in the CSF promotes infection of the CNS and provides a highly efficient pathway for the transfer of infectious virus to the periphery. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2006 journal article

Compartmentalization and evolution of feline immunodeficiency virus between the central nervous system and periphery following intracerebroventricular or systemic inoculation

JOURNAL OF NEUROVIROLOGY, 12(4), 307–321.

By: P. Liu n, L. Hudson n, M. Tompkins n, T. Vahlenkamp n & R. Meeker *

author keywords: brain; cerebrospinal fluid; dementia; evolution; heteroduplex tracking assay; HIV
MeSH headings : Animals; Brain / virology; Cats; Central Nervous System Diseases / blood; Central Nervous System Diseases / cerebrospinal fluid; Central Nervous System Diseases / virology; Feline Acquired Immunodeficiency Syndrome / blood; Feline Acquired Immunodeficiency Syndrome / cerebrospinal fluid; Feline Acquired Immunodeficiency Syndrome / virology; Genes, env; Heteroduplex Analysis; Immunodeficiency Virus, Feline / genetics; Immunodeficiency Virus, Feline / metabolism; Leukocytes, Mononuclear / virology; Peripheral Nervous System Diseases / blood; Peripheral Nervous System Diseases / cerebrospinal fluid; Peripheral Nervous System Diseases / virology; RNA, Viral / blood; RNA, Viral / cerebrospinal fluid
TL;DR: Early changes in virus evolution and compartmentalization between peripheral tissues and the central nervous system (CNS) after intracerebroventricular or intraperitoneal inoculation of animals with cell-free feline immunodeficiency virus (FIV) were tracked. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2005 article

The role of CD4(+)CD25(+) regulatory T cells in viral infections

Vahlenkamp, T. W., Tompkins, M. B., & Tompkins, W. A. F. (2005, October 18). VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, Vol. 108, pp. 219–225.

By: T. Vahlenkamp*, M. Tompkins n & W. Tompkins n

author keywords: regulatory T cells; viral infection; immune regulation; immunosuppression
MeSH headings : Animals; CD4-Positive T-Lymphocytes / immunology; Herpesviridae Infections / immunology; Immune Tolerance; Lymphocyte Activation; Mice; Picornaviridae Infections / immunology; Receptors, Interleukin-2 / metabolism; Retroviridae Infections / immunology; T-Lymphocyte Subsets / immunology; Virus Diseases / immunology
TL;DR: The findings that T reg cells influence the functional immunity during viral infections might indicate that, in some cases, virus-specific T reg Cells not only influence immune pathology or prevent pathogen elimination but also can promote a generalized state of immunosuppression in vivo such that the host is more susceptible to secondary infections with other pathogens or has reduced resistance to tumors. (via Semantic Scholar)
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Added: August 6, 2018

2004 journal article

B7(+)CTLA4(+) T cells engage in T-T cell interactions that mediate apoptosis: a model for lentivirus-induced T cell depletion

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 98(3-4), 203–214.

By: T. Vahlenkamp n, M. Bull n, J. Dow n, E. Collisson*, B. Winslow, A. Phadke*, W. Tompkins n, M. Tompkins n

author keywords: FIV; apoptosis; 137 costimulatory molecules; CTLA4
MeSH headings : Animals; Antigens, CD / biosynthesis; Antigens, CD / immunology; Antigens, Differentiation / biosynthesis; Antigens, Differentiation / immunology; Apoptosis / immunology; B7-1 Antigen / biosynthesis; B7-1 Antigen / immunology; B7-2 Antigen; CTLA-4 Antigen; Cats; Cell Communication / immunology; Concanavalin A / immunology; Feline Acquired Immunodeficiency Syndrome / immunology; Flow Cytometry / veterinary; Immunodeficiency Virus, Feline / immunology; In Situ Nick-End Labeling / veterinary; Ionomycin / immunology; Lymphocyte Activation / immunology; Membrane Glycoproteins / biosynthesis; Membrane Glycoproteins / immunology; Specific Pathogen-Free Organisms; T-Lymphocytes / immunology; T-Lymphocytes / virology; Tetradecanoylphorbol Acetate / immunology
TL;DR: The hypothesis that the chronic expansion of B7+CTLA4+ LN T cells in infected cats allows for T-T cell interactions resulting in T cell depletion and eventually the development of AIDS is supported. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2004 journal article

Combined anti-retroviral therapy (CART) in a feline immunodeficiency virus (FIV)infected cat

Kleintier-Praxis, 49(8), 517-.

By: J. Huebner, D. Klein, E. Muller, T. Vahlenkamp & I. Langbein

Source: NC State University Libraries
Added: August 6, 2018

2004 journal article

Feline immunodeficiency virus infection phenotypically and functionally activates immunosuppressive CD4(+)CD25(+) T regulatory cells

JOURNAL OF IMMUNOLOGY, 172(8), 4752–4761.

By: T. Vahlenkamp n, M. Tompkins n & W. Tompkins n

MeSH headings : Animals; Antigens, CD / biosynthesis; Antigens, CD / metabolism; Antigens, Differentiation / biosynthesis; Antigens, Viral / biosynthesis; B7-1 Antigen / biosynthesis; B7-1 Antigen / metabolism; B7-2 Antigen; CTLA-4 Antigen; Cats; Cell Division / immunology; Cell Separation; Cells, Cultured; Chronic Disease; Coculture Techniques; Concanavalin A / pharmacology; Feline Acquired Immunodeficiency Syndrome / immunology; Feline Acquired Immunodeficiency Syndrome / virology; Immune Tolerance; Immunodeficiency Virus, Feline / immunology; Immunophenotyping; Interleukin-2 / biosynthesis; Interleukin-2 / deficiency; Ligands; Lipopolysaccharides / pharmacology; Lymph Nodes / cytology; Lymph Nodes / immunology; Lymphocyte Activation / immunology; Lymphocyte Count; Membrane Glycoproteins / biosynthesis; Membrane Glycoproteins / metabolism; Receptors, Interleukin-2 / biosynthesis; Receptors, Interleukin-2 / blood; Receptors, Interleukin-2 / metabolism; T-Lymphocyte Subsets / immunology; T-Lymphocyte Subsets / metabolism; T-Lymphocyte Subsets / virology; T-Lymphocytes, Regulatory / immunology; T-Lymphocytes, Regulatory / metabolism; T-Lymphocytes, Regulatory / virology; Up-Regulation / immunology
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2004 journal article

Preferential replication of FIV in activated CD4(+)CD25(+)T cells independent of cellular proliferation

VIROLOGY, 321(2), 307–322.

By: A. Joshi n, T. Vahlenkamp n, H. Garg n, W. Tompkins n & M. Tompkins n

author keywords: FIV; HIV; AIDS; latency; stimulation; anergy; apoptosis; reservoir
MeSH headings : Animals; Apoptosis; CD4-Positive T-Lymphocytes / immunology; CD4-Positive T-Lymphocytes / virology; Cats; Cell Division / immunology; Disease Models, Animal; Feline Acquired Immunodeficiency Syndrome / immunology; Feline Acquired Immunodeficiency Syndrome / virology; Immunodeficiency Virus, Feline / physiology; Lymphocyte Activation; Receptors, Interleukin-2 / analysis; Virus Latency; Virus Replication
TL;DR: The ability of CD4(+)CD25(+) cells to replicate FIV efficiently in the presence of IL-2 but remain anergic and unresponsive to apoptotic signaling suggests that these cells may provide a reservoir of productive FIV infection. (via Semantic Scholar)
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2004 journal article

Spontaneous T cell apoptosis in feline immunodeficiency virus (FIV)-infected cats is inhibited by IL2 and anti-B7.1 antibodies

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 99(1-2), 25–37.

By: M. Bull n, T. Vahlenkamp n, J. Dow n, E. Collisson*, B. Winslow, A. Phadke*, M. Tompkins n, W. Tompkins n

author keywords: FIV; apoptosis; IL2; B7 co-stimulatory molecules; CTLA4
MeSH headings : Animals; Antibodies, Blocking / immunology; Antigens, CD / immunology; Apoptosis / drug effects; Apoptosis / immunology; B7-2 Antigen; CD4-Positive T-Lymphocytes / immunology; CD4-Positive T-Lymphocytes / pathology; CD4-Positive T-Lymphocytes / virology; CD8-Positive T-Lymphocytes / immunology; CD8-Positive T-Lymphocytes / pathology; CD8-Positive T-Lymphocytes / virology; Cats; Feline Acquired Immunodeficiency Syndrome / blood; Feline Acquired Immunodeficiency Syndrome / immunology; Immunodeficiency Virus, Feline / genetics; Immunodeficiency Virus, Feline / immunology; In Situ Nick-End Labeling / veterinary; Interleukin-2 / immunology; Interleukin-2 / pharmacology; Lymph Nodes / immunology; Lymphocyte Activation / immunology; Membrane Glycoproteins / antagonists & inhibitors; Membrane Glycoproteins / immunology; RNA, Viral / chemistry; RNA, Viral / genetics; Reverse Transcriptase Polymerase Chain Reaction / veterinary; Specific Pathogen-Free Organisms
TL;DR: A role of B7 signaling in the increased spontaneous apoptosis observed in LN T cells from FIV-infected animals is suggested. (via Semantic Scholar)
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2003 journal article

Generation of reference values for the characterization of lymphocyte subpopulations in the peripheral blood of dogs and cats

Kleintier-Praxis, 48(9), 537-.

By: I. Langbein, P. Kuhnlein, C. Schimmer, T. Vahlenkamp, J. Huebner & E. Muller

Source: NC State University Libraries
Added: August 6, 2018

2002 journal article

Cerebrospinal fluid centesis at the cerebellomedullary cistern of kittens

Contemporary Topics in Laboratory Animal Science, 41(5), 30–32.

By: L. Hudson, T. Vahlenkamp, K. Howard, B. Colby, M. Tompkins & R. Meeker

Source: NC State University Libraries
Added: August 6, 2018

2002 article

Feline immunodeficiency virus infection is characterized by B7(+)CTLA4(+) T cell apoptosis

Tompkins, M. B., Bull, M. E., Dow, J. L., Ball, J. M., Collisson, E. W., Winslow, B. J., … Tompkins, W. A. (2002, April 15). JOURNAL OF INFECTIOUS DISEASES, Vol. 185, pp. 1077–1093.

By: M. Tompkins n, M. Bull n, J. Dow n, J. Ball*, E. Collisson*, B. Winslow, A. Phadke*, T. Vahlenkamp n, W. Tompkins n

MeSH headings : Abatacept; Animals; Antigens, CD / analysis; Antigens, Differentiation / analysis; Apoptosis; B7-1 Antigen / analysis; B7-2 Antigen; CTLA-4 Antigen; Cats; Feline Acquired Immunodeficiency Syndrome / immunology; Immunoconjugates; In Situ Nick-End Labeling; Membrane Glycoproteins / analysis; T-Lymphocytes / physiology
TL;DR: Data support the hypothesis that lymph node apoptosis and immune deterioration in FIV-infected cats results from chronic B7.1- and/or B.2-CTLA4-mediated T-T interactions. (via Semantic Scholar)
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2002 journal article

Persistence of Borna disease virus in naturally infected sheep

JOURNAL OF VIROLOGY, 76(19), 9735–9743.

By: T. Vahlenkamp*, A. Konrath *, M. Weber * & H. Muller*

MeSH headings : Animals; Antibodies, Viral / analysis; Borna Disease / virology; Borna disease virus / immunology; Borna disease virus / isolation & purification; Glycoproteins / chemistry; Glycoproteins / genetics; Immunohistochemistry; In Situ Hybridization; Male; RNA, Viral / analysis; Reverse Transcriptase Polymerase Chain Reaction; Sheep; Sheep Diseases / virology; Viral Proteins / chemistry; Viral Proteins / genetics
TL;DR: An isolated flock of approximately 25 sheep within the region of Southeast Germany to which the disease is endemic was investigated over a 3-year observation period, finding that numbers of antibody-positive and viral-RNA-positive animals increased significantly despite their having no obvious clinical symptoms. (via Semantic Scholar)
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Added: August 6, 2018

2001 conference paper

B7.1/B7.2 and CTLA4 expression on feline T cells in vitro correlates with apoptosis

Journal of Leukocyte Biology, (2001), 255.

By: T. Vahlenkamp, M. Bull, J. Dow, J. Anderson, M. Tompkins & W. Tompkins

Source: NC State University Libraries
Added: August 6, 2018

2001 journal article

Changes of the organotypic retinal organization in Borna virus-infected Lewis rats

JOURNAL OF NEUROCYTOLOGY, 30(9-10), 801–820.

By: J. Kacza*, C. Mohr, T. Pannicke, H. Kuhrt, J. Dietzel, M. Fluss, J. Richt, T. Vahlenkamp* ...

MeSH headings : Animals; Antigens, Viral / metabolism; Borna Disease / pathology; Borna Disease / physiopathology; Borna disease virus / metabolism; Borna disease virus / pathogenicity; Disease Models, Animal; Glial Fibrillary Acidic Protein / metabolism; Immunohistochemistry; Membrane Potentials / physiology; Microglia / pathology; Microglia / ultrastructure; Microglia / virology; Microscopy, Electron; Organ Culture Techniques; Photoreceptor Cells / pathology; Photoreceptor Cells / ultrastructure; Photoreceptor Cells / virology; Rats; Rats, Inbred Lew; Retina / pathology; Retina / ultrastructure; Retina / virology; Retinal Diseases / pathology; Retinal Diseases / physiopathology; Retinal Diseases / virology; Retinal Ganglion Cells / pathology; Retinal Ganglion Cells / ultrastructure; Retinal Ganglion Cells / virology
TL;DR: These findings demonstrate for the first time long-term neuron-glia interactions in the retina of BDV-infected rats, and contribute to the knowledge on structural and functional alterations accompanying persisting virus infection in the central nervous system. (via Semantic Scholar)
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2001 conference paper

T cell apoptosis in FIV-infected cats is blocked by the addition of antibodies to B7.1 and B7.2

Journal of Leukocyte Biology, (2001), 256.

By: M. Bull, T. Vahlenkamp, M. Tompkins & W. Tompkins

Source: NC State University Libraries
Added: August 6, 2018

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