2002 journal article

Identification and quantification of protecting groups remaining in commercial oligonucleotide products using monoclonal antibodies


By: C. Fu n, S. Smith n, S. Simkins n & P. Agris n

author keywords: DNA; RNA; automated synthesis; protecting group detection; quality control
MeSH headings : Antibodies, Monoclonal / immunology; Antibody Specificity; Chromatography, High Pressure Liquid; DNA / chemistry; DNA / immunology; Enzyme-Linked Immunosorbent Assay; Immunoblotting / methods; Molecular Structure; Oligonucleotides / chemistry; Oligonucleotides / immunology; Quality Control; RNA / chemistry; RNA / immunology; Sensitivity and Specificity; Spectrum Analysis
TL;DR: Monoclonal antibodies selectively identify and quantify picomoles of remaining protecting groups on antisense therapeutics and oligonucleotide diagnostics. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2002 personal communication

QC in antisense oligo synthesis

By: P. Agris, S. Smith, C. Fu & S. Simkins

Source: NC State University Libraries
Added: August 6, 2018

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