Amitabh C. Sehgal

Works (5)

Updated: July 5th, 2023 16:00

2009 journal article

Energy stores are not altered by long-term partial sleep deprivation in Drosophila melanogaster

PLoS One, 4(7).

By: S. Harbison & A. Sehgal

Source: NC State University Libraries
Added: August 6, 2018

2008 article

Quantitative Genetic Analysis of Sleep inDrosophila melanogaster

Harbison, S. T., & Sehgal, A. (2008, April 1). Genetics.

By: S. Harbison* & A. Sehgal*

MeSH headings : Alleles; Analysis of Variance; Animals; Drosophila melanogaster / genetics; Energy Metabolism / genetics; Female; Gene Expression Regulation; Male; Mutagenesis, Insertional; Phenotype; Quantitative Trait, Heritable; RNA, Messenger / genetics; RNA, Messenger / metabolism; Sex Characteristics; Sleep / genetics; Time Factors; Wakefulness / genetics
topics (OpenAlex): Neurobiology and Insect Physiology Research; Insect and Arachnid Ecology and Behavior; Circadian rhythm and melatonin
TL;DR: Mutational genetic correlations among sleep parameters revealed that the genetic basis of the transition between sleep and waking states in males and females may be different, suggesting that sleep may serve a number of different functions rather than a single purpose. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2003 article

Strategic Selection of Hyperthermophilic Esterases for Resolution of 2‐Arylpropionic Esters

Sehgal, A. C., & Kelly, R. M. (2003, January 1). Biotechnology Progress, Vol. 19, pp. 1410–1416.

By: A. Sehgal n & R. Kelly n 

MeSH headings : Amino Acid Sequence; Candida / enzymology; Candida / genetics; Catalysis; Enzyme Stability; Esterases / biosynthesis; Esterases / chemistry; Esterases / genetics; Esterases / isolation & purification; Esters; Hydrolysis; Molecular Sequence Data; Naproxen / analogs & derivatives; Naproxen / chemistry; Protein Engineering / methods; Pyrococcus furiosus / enzymology; Pyrococcus furiosus / genetics; Recombinant Proteins / biosynthesis; Recombinant Proteins / chemistry; Sequence Alignment / methods; Sequence Analysis, Protein / methods; Species Specificity; Stereoisomerism; Sulfolobus / enzymology; Sulfolobus / genetics
topics (OpenAlex): Enzyme Catalysis and Immobilization; Analytical Chemistry and Chromatography; Microbial Metabolic Engineering and Bioproduction
TL;DR: The results here show that although bioinformatics tools can be used to select candidate biocatalysts for chiral resolution of 2‐arylpropionic esters, biochemical characterization is needed to definitively determine functional characteristics. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2002 article

Enantiomeric Resolution of 2-Aryl Propionic Esters with Hyperthermophilic and Mesophilic Esterases:  Contrasting Thermodynamic Mechanisms

Sehgal, A. C., & Kelly, R. M. (2002, June 19). Journal of the American Chemical Society, Vol. 124, pp. 8190–8191.

By: A. Sehgal n & R. Kelly n 

MeSH headings : Candida / enzymology; Carboxylesterase; Carboxylic Ester Hydrolases / chemistry; Esterases / chemistry; Esters / chemistry; Esters / isolation & purification; Lipase / chemistry; Naproxen / chemistry; Naproxen / isolation & purification; Propionates / chemistry; Propionates / isolation & purification; Rhizomucor / enzymology; Stereoisomerism; Substrate Specificity; Sulfolobus / enzymology; Thermodynamics
topics (OpenAlex): Enzyme Catalysis and Immobilization; Analytical Chemistry and Chromatography; Chemical Reaction Mechanisms
TL;DR: The enantiomeric resolution of 2-aryl propionic esters by hyperthermophilic and mesophilic esterases was found to be governed by contrasting thermodynamic mechanisms. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2002 article

Structural and catalytic response to temperature and cosolvents of carboxylesterase EST1 from the extremely thermoacidophilic archaeon Sulfolobus solfataricus P1

Sehgal, A. C., Tompson, R., Cavanagh, J., & Kelly, R. M. (2002, October 23). Biotechnology and Bioengineering, Vol. 80, pp. 784–793.

By: A. Sehgal n, R. Tompson n, J. Cavanagh n & R. Kelly n 

author keywords: DMSO; conformational flexibility; enzyme activation; thermostable
MeSH headings : Acetonitriles / chemistry; Carboxylesterase; Carboxylic Ester Hydrolases / biosynthesis; Carboxylic Ester Hydrolases / chemistry; Carboxylic Ester Hydrolases / isolation & purification; Catalysis; Dimethyl Sulfoxide / chemistry; Dimethylformamide / chemistry; Dioxanes / chemistry; Enzyme Activation; Enzyme Stability; Molecular Conformation; Quality Control; Sensitivity and Specificity; Solvents / chemistry; Species Specificity; Structure-Activity Relationship; Sulfolobus / classification; Sulfolobus / enzymology; Temperature
topics (OpenAlex): Enzyme Catalysis and Immobilization; Cholinesterase and Neurodegenerative Diseases; Enzyme function and inhibition
TL;DR: Results suggest cosolvents may also serve as activators in applications involving thermostable biocatalysts at sub-optimal temperatures, related to small changes in the enzyme's structure resulting in an increase in its conformational flexibility. (via Semantic Scholar)
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6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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