Clayton D. Chilcoat

Works (2)

Updated: July 5th, 2023 16:00

2008 journal article

Tonic protein kinase A activity maintains inactive beta 2 integrins in unstimulated neutrophils by reducing myosin light-chain phosphorylation: role of myosin light-chain kinase and Rho kinase

JOURNAL OF LEUKOCYTE BIOLOGY, 83(4), 964–971.

By: C. Chilcoat n, Y. Sharief n & S. Jones n 

author keywords: PMN; PKA; ROCK; avidity; adhesion; cytoskeleton
MeSH headings : Adult; CD18 Antigens / blood; CD18 Antigens / drug effects; Carbazoles / pharmacology; Cell Adhesion; Cyclic AMP-Dependent Protein Kinases / antagonists & inhibitors; Cyclic AMP-Dependent Protein Kinases / blood; Homeostasis; Humans; Indoles / pharmacology; Myosin-Light-Chain Kinase / blood; Neutrophils / enzymology; Neutrophils / physiology; Oligopeptides / pharmacology; Phosphorylation; Pyrroles / pharmacology; rho-Associated Kinases / blood
TL;DR: It is demonstrated that tonic PKA activity prevents activation of β2 integrins and adhesion by inhibiting MLC phosphorylation via a MLCK‐dependent but ROCK‐independent pathway. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2002 journal article

The effects of cAMP modulation upon the adhesion and respiratory burst activity of immune complex-stimulated equine neutrophils

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 88(1-2), 65–77.

By: C. Chilcoat n, K. Rowlingson n & S. Jones n 

author keywords: neutrophil; cAMP; adhesion; integrin; immune complex
MeSH headings : Adrenergic beta-Agonists / pharmacology; Animals; Antigen-Antibody Complex / immunology; Cell Adhesion / immunology; Clenbuterol / pharmacology; Cyclic AMP / antagonists & inhibitors; Cyclic AMP / immunology; Cyclic AMP-Dependent Protein Kinases / immunology; Horses / blood; Horses / immunology; Isoproterenol / pharmacology; Neutrophils / cytology; Neutrophils / immunology; Pentoxifylline / pharmacology; Phosphodiesterase Inhibitors / pharmacology; Respiratory Burst / immunology; Rolipram / pharmacology
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UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

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