@article{yang_lin_wang_2005, title={A new type of boronic acid fluorescent reporter compound for sugar recognition}, volume={46}, ISSN={["0040-4039"]}, DOI={10.1016/j.tetlet.2005.09.074}, abstractNote={Fluorescent boronic acids that change fluorescent properties upon carbohydrate binding are very useful for the preparation of fluorescent sensors for sugars. Herein we report 5-quinolineboronic acid (5-QBA) that shows significant fluorescent property changes through a unique pKa-switching mechanism upon binding a diol in aqueous solution.}, number={46}, journal={TETRAHEDRON LETTERS}, author={Yang, WQ and Lin, L and Wang, BH}, year={2005}, month={Nov}, pages={7981–7984} } @misc{wang_weston_yang_2005, title={Fluorescent sensor compounds for detecting saccharides}, volume={6,916,660}, publisher={Washington, DC: U.S. Patent and Trademark Office}, author={Wang, B. and Weston, B. and Yang, W.}, year={2005} } @article{chen_yang_sivamani_bruneau_wang_qu_2005, title={Selective elimination of perennial ryegrass by activation of a pro-herbicide through engineering E-coli argE gene}, volume={15}, ISSN={["1572-9788"]}, DOI={10.1007/s11032-004-7243-z}, number={4}, journal={MOLECULAR BREEDING}, author={Chen, X and Yang, WQ and Sivamani, E and Bruneau, AH and Wang, BH and Qu, RD}, year={2005}, month={May}, pages={339–347} } @article{yang_li_wang_2004, title={A new type of water-soluble fluorescent boronic acid suitable for construction of polyboronic acids for carbohydrate recognition}, volume={10}, number={6}, journal={Heterocyclic Communications}, author={Yang, W. Q. and Li, L. and Wang, B. H.}, year={2004}, pages={383–388} } @article{zych_yang_liao_griffin_wang_2004, title={The effect of substitution patterns on the release rates of opioid peptides DADLE and [Leu(5)]-enkephalin from coumarin prodrug moieties}, volume={32}, ISSN={["1090-2120"]}, DOI={10.1016/j.bioorg.2003.12.002}, abstractNote={A coumarin-based prodrug system has been developed in our laboratory for the preparation of esterase-sensitive prodrugs of amines, peptides, and peptidomimetics. The drug release rates from this prodrug system were found to be dependent on the structural features of the drug moiety. The effect of the phenyl ring substitutions on the release kinetics of such prodrugs of model amines was examined recently and it was found that appropriately positioned alkyl substituents on the phenyl ring could help to facilitate the release. Aimed at further understanding the structure-release rate relationship of the coumarin-based cyclic prodrugs, we synthesized and examined a series of substituted coumarinic acid derivatives of opioid peptides, DADLE, and [Leu(5)]-enkephalin.}, number={2}, journal={BIOORGANIC CHEMISTRY}, author={Zych, LA and Yang, WQ and Liao, Y and Griffin, KR and Wang, BH}, year={2004}, month={Apr}, pages={109–123} } @article{yang_yan_springsteen_deeter_wang_2003, title={A novel type of fluorescent boronic acid that shows large fluorescence intensity changes upon binding with a carbohydrate in aqueous solution at physiological pH}, volume={13}, ISSN={["1464-3405"]}, DOI={10.1016/S0960-894X(03)00086-6}, abstractNote={In this paper we report 8-quinolineboronic acid as a novel type of fluorescent probe for carbohydrates. This boronic acid responds to the binding of a carbohydrate with over 40-fold increases in fluorescence intensity and shows optimal fluorescence change at physiological pH in aqueous solution.}, number={6}, journal={BIOORGANIC & MEDICINAL CHEMISTRY LETTERS}, author={Yang, WQ and Yan, J and Springsteen, G and Deeter, S and Wang, BH}, year={2003}, month={Mar}, pages={1019–1022} } @misc{yang_gao_wang_2003, title={Boronic acid compounds as potential pharmaceutical agents}, volume={23}, ISSN={["1098-1128"]}, DOI={10.1002/med.10043}, abstractNote={Abstract}, number={3}, journal={MEDICINAL RESEARCH REVIEWS}, author={Yang, WQ and Gao, XM and Wang, BH}, year={2003}, month={May}, pages={346–368} } @article{yang_yan_fang_wang_2003, title={The first fluorescent sensor for D-glucarate based on the cooperative action of boronic acid and guanidinium groups}, ISSN={["1364-548X"]}, DOI={10.1039/b300098b}, abstractNote={A new fluorescent sensor (1) with a recognition unit consisting of a boronic acid moiety and a guanidinium unit shows selective binding of D-glucarate in aqueous solution.}, number={6}, journal={CHEMICAL COMMUNICATIONS}, author={Yang, WQ and Yan, J and Fang, H and Wang, BH}, year={2003}, pages={792–793} } @article{karnati_gao_gao_yang_ni_sankar_wang_2002, title={A glucose-selective fluorescence sensor based on boronic acid-diol recognition}, volume={12}, ISSN={["0960-894X"]}, DOI={10.1016/S0960-894X(02)00767-9}, abstractNote={A glucose selective diphenylboronic acid fluorescent sensor (10a) with a K(a) of 1472M(-1) has been synthesized and evaluated. This sensor shows a 43- and 49-fold selectivity for glucose over fructose and galactose, respectively. The binding affinity improvement is about 300-fold and the selectivity improvement for glucose over fructose is about 1400-fold compared with the monoboronic acid compound, phenylboronic acid. 1H NMR studies indicate that sensor 10a binds with alpha-D-glucofuranose in a bidentate manner (1:1 ratio).}, number={23}, journal={BIOORGANIC & MEDICINAL CHEMISTRY LETTERS}, author={Karnati, VV and Gao, XM and Gao, SH and Yang, WQ and Ni, WJ and Sankar, S and Wang, BH}, year={2002}, month={Dec}, pages={3373–3377} } @article{yang_gao_springsteen_wang_2002, title={Catechol pendant polystyrene for solid-phase synthesis}, volume={43}, ISSN={["0040-4039"]}, DOI={10.1016/S0040-4039(02)01370-9}, abstractNote={A catechol pendant polystyrene polymer was prepared from the Merrifield resin via a convenient procedure with high-density loading. Due to the high affinity binding between catechol and boronic acid, the polymer resin readily captures boronic acid compounds. The feasibility of using immobilized catechol to capture boronic acid products for purification and solid-phase transformation was demonstrated. Moreover, the immobilized catechol was also used for the preparation of resin-bound catecholborane, which can be used as a solid-phase amidation reagent.}, number={36}, journal={TETRAHEDRON LETTERS}, author={Yang, WQ and Gao, XM and Springsteen, G and Wang, BH}, year={2002}, month={Sep}, pages={6339–6342} } @article{yang_gao_gao_karnati_ni_wang_hooks_carson_weston_2002, title={Diboronic acids as fluorescent probes for cells expressing sialyl Lewis X}, volume={12}, ISSN={["0960-894X"]}, DOI={10.1016/S0960-894X(02)00339-6}, abstractNote={A series of fluorescent diboronic acids was synthesized in nine steps as potential sensors for sialyl Lewis X (sLex). The fluorescent binding studies of these sensors with sLex were carried out in a mixed aqueous solution. Compound 7e was found to show the strongest fluorescence enhancement upon binding with sLex. Using cell cultures, 7e was shown to label sLex-expressing HEPG2 cells at 1 microM, while non-sLex-expressing cells were not labeled.}, number={16}, journal={BIOORGANIC & MEDICINAL CHEMISTRY LETTERS}, author={Yang, WQ and Gao, SH and Gao, XM and Karnati, VVR and Ni, WJ and Wang, BH and Hooks, WB and Carson, J and Weston, B}, year={2002}, month={Aug}, pages={2175–2177} }