Gretchen L. Geiger-Thornsberry

2004 journal article

Quantitative trait loci affecting natural variation in Drosophila longevity

MECHANISMS OF AGEING AND DEVELOPMENT, 125(3), 179–189.

By: G. Geiger-Thornsberry n & T. Mackay n

author keywords: QTL mapping; quantitative complementation tests; candidate genes
MeSH headings : Aging / genetics; Animals; Drosophila Proteins / genetics; Drosophila melanogaster / genetics; Female; Genetic Complementation Test; Genetic Variation; Longevity / genetics; Male; Quantitative Trait Loci
TL;DR: Several genes that regulate life span complemented the life span effects of wild-derived alleles, suggesting little natural variation affecting longevity at these loci, at least in this sample of alleles. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2003 journal article

Dopa decarboxylase (Ddc) affects variation in Drosophila longevity

NATURE GENETICS, 34(4), 429–433.

By: M. De Luca n, N. Roshina*, G. Geiger-Thornsberry n, R. Lyman n, E. Pasyukova* & T. Mackay n

MeSH headings : Animals; Base Sequence; Chromosome Mapping; DNA / genetics; Dopa Decarboxylase / genetics; Drosophila melanogaster / enzymology; Drosophila melanogaster / genetics; Female; Genes, Insect; Genetic Complementation Test; Genetic Variation; Longevity / genetics; Male; Molecular Sequence Data; Mutation; Polymorphism, Genetic; Quantitative Trait Loci; Sequence Homology, Nucleic Acid; Species Specificity
TL;DR: Variation in the synthesis of bioamines as a factor contributing to natural variation in individual life span is implicate by mapping quantitative trait loci affecting variation in longevity between two Drosophila melanogaster strains. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2002 journal article

Association of single-nucleotide polymorphisms at the Delta locus with genotype by environment interaction for sensory bristle number in Drosophila melanogaster

GENETICS RESEARCH, 79(3), 211–218.

By: G. Geiger-Thornsberry n & T. Mackay n

MeSH headings : Abdomen / physiology; Animals; Drosophila melanogaster / genetics; Environment; Genetic Variation; Genotype; Intracellular Signaling Peptides and Proteins; Membrane Proteins / genetics; Polymorphism, Single Nucleotide; Quantitative Trait, Heritable; Sense Organs / physiology
TL;DR: Heterozygotes for the abdominal bristle number SNPs were indeed the most stable genotype for two of the three environment pairs exhibiting GEI, but the mean genotypic effect was greater than the standard deviation of effects across environments, so this mechanism of GEI seems unlikely to be responsible for maintaining the common bristle numbers at Dl. (via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action (Web of Science)
15. Life on Land (Web of Science)
Source: Web Of Science
Added: August 6, 2018

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