Robyn Jones Medinas

Works (1)

Updated: July 5th, 2023 15:59

2002 journal article

C-terminal gp40 peptide analogs inhibit feline immunodeficiency virus: Cell fusion and virus spread

JOURNAL OF VIROLOGY, 76(18), 9079–9086.

By: R. Medinas n, D. Lambert & W. Tompkins n

MeSH headings : Amino Acid Sequence; Animals; Antiviral Agents / chemical synthesis; Antiviral Agents / chemistry; Antiviral Agents / pharmacology; Cats; Cell Fusion; Dose-Response Relationship, Drug; HIV Envelope Protein gp41 / chemistry; HIV-1 / drug effects; HIV-1 / physiology; HeLa Cells; Humans; Immunodeficiency Virus, Feline / drug effects; Immunodeficiency Virus, Feline / physiology; Membrane Fusion / drug effects; Microbial Sensitivity Tests; Molecular Sequence Data; Peptide Fragments / chemical synthesis; Peptide Fragments / chemistry; Peptide Fragments / pharmacology; Protein Structure, Tertiary; Viral Plaque Assay
TL;DR: Synthetic peptides derived from the HR2 domain of the FIV gp41 protein are effective inhibitors of FIV infection, demonstrating the conservation of the gp41 ectodomain among lentiviruses. (via Semantic Scholar)
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