Works (15)

Updated: July 5th, 2023 15:59

2016 journal article

Sustained Release of Protein Therapeutics from Subcutaneous Thermosensitive Biocompatible and Biodegradable Pentablock Copolymers (PTSgels)

JOURNAL OF DRUG DELIVERY, 2016.

By: E. Schaefer n, S. Abbaraju*, M. Walsh n, D. Newman n, J. Salmon n, R. Amin*, S. Weiss, U. Grau ...

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
Sources: Web Of Science, ORCID
Added: August 6, 2018

2015 journal article

Expression of WNT5A in Idiopathic Pulmonary Fibrosis and Its Control by TGF-ฮฒ and WNT7B in Human Lung Fibroblasts

Journal of Histochemistry & Cytochemistry, 64(2), 99โ€“111.

By: D. Newman n, W. Sills n, K. Hanrahan n, A. Ziegler nโ€‰, K. Tidd n, E. Cook n, P. Sannes n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Cells, Cultured; Fibroblasts / metabolism; Fibroblasts / pathology; Gene Expression Regulation; Gene Silencing; Humans; Idiopathic Pulmonary Fibrosis / genetics; Idiopathic Pulmonary Fibrosis / metabolism; Idiopathic Pulmonary Fibrosis / pathology; Lung / metabolism; Lung / pathology; Myocytes, Smooth Muscle / metabolism; Myofibroblasts / metabolism; Myofibroblasts / pathology; Proto-Oncogene Proteins / analysis; Proto-Oncogene Proteins / genetics; Proto-Oncogene Proteins / metabolism; Transforming Growth Factor beta / analysis; Transforming Growth Factor beta / genetics; Transforming Growth Factor beta / metabolism; Up-Regulation; Wnt Proteins / analysis; Wnt Proteins / genetics; Wnt Proteins / metabolism; Wnt-5a Protein
Sources: NC State University Libraries, ORCID, Crossref
Added: August 6, 2018

2015 journal article

Heparin and LPS-induced COX-2 expression in airway cells: a link between its anti-inflammatory effects and GAG sulfation

EXPERIMENTAL LUNG RESEARCH, 41(9), 499โ€“513.

By: N. Yi n, D. Newman n, H. Zhang n, H. Johanssonโ€‰ n & P. Sannes n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: COX-2; heparin; LPS; lung; sulfation
MeSH headings : Anti-Inflammatory Agents, Non-Steroidal / chemistry; Anti-Inflammatory Agents, Non-Steroidal / pharmacology; Cell Line; Cyclooxygenase 2 / genetics; Cyclooxygenase 2 / metabolism; Gene Expression / drug effects; Glycosaminoglycans / chemistry; Glycosaminoglycans / metabolism; Heparin / chemistry; Heparin / pharmacology; Humans; Interleukin-8 / genetics; Interleukin-8 / metabolism; Lipopolysaccharides / toxicity; MAP Kinase Signaling System / drug effects; RNA, Messenger / genetics; RNA, Messenger / metabolism; Respiratory Mucosa / cytology; Respiratory Mucosa / drug effects; Respiratory Mucosa / metabolism
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Whole-Genome Analysis of Temporal Gene Expression during Early Transdifferentiation of Human Lung Alveolar Epithelial Type 2 Cells In Vitro

PLOS ONE, 9(4).

By: H. Johanssonโ€‰ n, D. Newman n & P. Sannes n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Alveolar Epithelial Cells / cytology; Alveolar Epithelial Cells / metabolism; Caveolin 1 / genetics; Caveolin 1 / metabolism; Cell Transdifferentiation / genetics; Cells, Cultured; Gene Expression; Gene Expression Profiling; Gene Expression Regulation; Genome-Wide Association Study; Humans; Protein Transport; Reproducibility of Results; Time Factors; Transcriptome
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Expression of Fibroblast Growth Factor 9 in Normal Human Lung and Idiopathic Pulmonary Fibrosis

JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 61(9), 671โ€“679.

By: E. Coffey n, D. Newman n & P. Sannes n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: smooth muscle cells; myofibroblast; metaplastic epithelium
MeSH headings : Adult; Cells, Cultured; Fibroblast Growth Factor 9 / analysis; Fibroblast Growth Factor 9 / metabolism; Humans; Idiopathic Pulmonary Fibrosis / metabolism; Idiopathic Pulmonary Fibrosis / pathology; Immunohistochemistry; Lung / metabolism; Lung / pathology; Lung / ultrastructure; Myocytes, Smooth Muscle / metabolism; Myocytes, Smooth Muscle / pathology; Myocytes, Smooth Muscle / ultrastructure; Myofibroblasts / metabolism; Myofibroblasts / pathology; Myofibroblasts / ultrastructure
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Over-expression of human endosulfatase-1 exacerbates cadmium-induced injury to transformed human lung cells in vitro

TOXICOLOGY AND APPLIED PHARMACOLOGY, 265(1), 27โ€“42.

By: H. Zhang n, D. Newman n, J. Bonner n & P. Sannes n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: Cadmium; HSulf-1; Lung epithelial injury; 6-O-sulfate
MeSH headings : Adenoviridae / genetics; Apoptosis / drug effects; Blotting, Western; Cadmium / toxicity; Cell Count; Cell Line, Tumor; Cell Survival / drug effects; Cell Transformation, Neoplastic / drug effects; Coloring Agents; Down-Regulation / drug effects; Heparan Sulfate Proteoglycans / pharmacology; Humans; In Situ Nick-End Labeling; Lac Operon / genetics; Lung / pathology; Polymerase Chain Reaction; Respiratory Mucosa / pathology; Sulfotransferases / biosynthesis; Sulfotransferases / physiology; Tetrazolium Salts; Thiazoles; Transduction, Genetic; Up-Regulation / drug effects
Source: Web Of Science
Added: August 6, 2018

2012 journal article

WNT7B in fibroblastic foci of idiopathic pulmonary fibrosis

Respiratory Research, 13(1), 62.

By: T. Meuten n, A. Hickey n, K. Franklin n, B. Grossi n, J. Tobias n, D. Newman n, S. Jennings n, M. Correaโ€‰ n, P. Sannes n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: Myofibroblasts; Alveolar epithelium; Interstitial lung disease
MeSH headings : Aged; Aged, 80 and over; Basement Membrane / pathology; Female; Fibroblasts / pathology; Humans; Idiopathic Pulmonary Fibrosis / metabolism; Idiopathic Pulmonary Fibrosis / pathology; Macrophages / pathology; Male; Middle Aged; Muscle, Smooth / pathology; Respiratory Mucosa / pathology; Respiratory System / blood supply; Respiratory System / pathology; Severity of Illness Index; Wnt Proteins / analysis; Wnt Proteins / metabolism
Sources: Web Of Science, Crossref
Added: August 6, 2018

2011 journal article

Heterotaxin: A TGF-beta Signaling Inhibitor Identified in a Multi-Phenotype Profiling Screen in Xenopus Embryos

CHEMISTRY & BIOLOGY, 18(2), 252โ€“263.

By: M. Dush n, A. McIver n, M. Parr n, D. Young n, J. Fisher n, D. Newman n, P. Sannes n, M. Hauck n, A. Deiters n, N. Nascone-Yoder n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Animals; Cell Line; Drug Evaluation, Preclinical; Embryo, Nonmammalian / abnormalities; Embryo, Nonmammalian / cytology; Embryo, Nonmammalian / drug effects; Embryo, Nonmammalian / metabolism; Humans; Intracellular Space / drug effects; Intracellular Space / metabolism; Neovascularization, Physiologic / drug effects; Phenotype; Pyridines / chemistry; Pyridines / pharmacology; Signal Transduction / drug effects; Stereoisomerism; Structure-Activity Relationship; Transforming Growth Factor beta / metabolism; Xenopus laevis
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Temporal Changes in Expression of FoxA1 and Wnt7A in Isolated Adult Human Alveolar Epithelial Cells Enhanced by Heparin

ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY, 293(6), 938โ€“946.

By: K. Apparao n, D. Newman n, H. Zhang n, J. Khosla n, S. Randellโ€‰* & P. Sannes n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: beta-catenin; differentiation; heparin; sulfated extracellular matrices
MeSH headings : Adult; Anticoagulants / physiology; Biomarkers / metabolism; Cell Differentiation / drug effects; Cell Differentiation / physiology; Cell Line; Cell Separation; Cells, Cultured; Heparin / physiology; Hepatocyte Nuclear Factor 3-alpha / biosynthesis; Hepatocyte Nuclear Factor 3-alpha / genetics; Humans; Pulmonary Alveoli / cytology; Pulmonary Alveoli / drug effects; Pulmonary Alveoli / metabolism; Respiratory Mucosa / cytology; Respiratory Mucosa / drug effects; Respiratory Mucosa / metabolism; Time Factors; Wnt Proteins / biosynthesis; Wnt Proteins / genetics; beta Catenin / biosynthesis; beta Catenin / genetics
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Alterations in cytoskeletal and immune function-related proteome profiles in whole rat lung following intratracheal instillation of heparin

RESPIRATORY RESEARCH, 8.

By: A. Gabr n, M. Reed*, D. Newman n, J. Pohl*, J. Khosla n & P. Sannes n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Administration, Inhalation; Animals; Anticoagulants / administration & dosage; Cytoskeleton / drug effects; Cytoskeleton / ultrastructure; Gene Expression Regulation / drug effects; Heparin / administration & dosage; Lung / drug effects; Lung / immunology; Lung / ultrastructure; Proteome / drug effects; Proteomics / methods; Rats; Rats, Inbred F344; Reference Values
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Fibroblast growth factor-binding protein and N-deacetylase/N-sulfotransferase-1 expression in type II cells is modulated by heparin and extracellular matrix

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 293(5), L1314โ€“L1320.

By: D. Newman*, E. Walsh*, K. Apparao & P. Sannes*

author keywords: coculture; alveolus; sulfation
MeSH headings : Animals; Carrier Proteins / genetics; Carrier Proteins / metabolism; Cells, Cultured; Extracellular Matrix / metabolism; Fibroblasts / cytology; Fibroblasts / metabolism; Heparin / pharmacology; Intercellular Signaling Peptides and Proteins; Lung / cytology; Lung / metabolism; Pulmonary Alveoli / cytology; Pulmonary Alveoli / metabolism; RNA, Messenger / genetics; RNA, Messenger / metabolism; Rats; Reverse Transcriptase Polymerase Chain Reaction; Sulfotransferases / genetics; Sulfotransferases / metabolism
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Heparin and fibroblast growth factors affect surfactant protein gene expression in type II cells

American Journal of Respiratory Cell and Molecular Biology, 35(5), 611โ€“618.

Source: NC State University Libraries
Added: August 6, 2018

2004 journal article

Heparin affects signaling pathways stimulated by fibroblast growth factor-1 and-2 in type II cells

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 287(1), L191โ€“L200.

By: D. Newman*, C. Li*, R. Simmons*, J. Khosla* & P. Sannes*

author keywords: extracellular matrix; basement membrane; receptor tyrosine kinase phosphorylation; ERK pathway; fibroblast growth factor signaling
MeSH headings : Animals; Cells, Cultured; Dose-Response Relationship, Drug; Drug Synergism; Fibroblast Growth Factor 1 / pharmacology; Fibroblast Growth Factor 2 / pharmacology; Heparin / administration & dosage; Heparin / pharmacology; Mitogen-Activated Protein Kinases / metabolism; Phosphorylation / drug effects; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins / metabolism; Proto-Oncogene Proteins c-akt; Pulmonary Alveoli / cytology; Pulmonary Alveoli / drug effects; Pulmonary Alveoli / metabolism; Pulmonary Alveoli / physiology; Rats; Rats, Inbred Strains; Signal Transduction / drug effects; Sulfates / metabolism; Thymidine / metabolism; Time Factors
Source: Web Of Science
Added: August 6, 2018

2003 article

Modulation of fibroblast growth factor expression and signal transduction in type II cells

Li, C. M., Newman, D., Cesta, M., Tompkins, L., Khosla, J., & Sannes, P. L. (2003, March). CHEST, Vol. 123, pp. 429Sโ€“429S.

By: C. Li n, D. Newman n, M. Cesta n, L. Tompkins n, J. Khosla n & P. Sannes n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Antigenic Modulation / genetics; Antigenic Modulation / immunology; Asthma / genetics; Asthma / immunology; Epithelial Cells / immunology; Fibroblast Growth Factors / genetics; Fibroblast Growth Factors / immunology; Gene Expression / genetics; Gene Expression / immunology; Humans; In Vitro Techniques; Signal Transduction / genetics; Signal Transduction / immunology
Source: Web Of Science
Added: August 6, 2018

2002 journal article

Heparin inhibits DNA synthesis and gene expression in alveolar type II cells

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 27(3), 345โ€“352.

By: C. Li n, D. Newman n, J. Khosla n & P. Sannes n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Animals; Cell Division / drug effects; Cells, Cultured; DNA / biosynthesis; DNA / drug effects; Extracellular Matrix / drug effects; Extracellular Matrix / metabolism; Fibroblast Growth Factor 1 / genetics; Fibroblast Growth Factor 1 / metabolism; Fibroblast Growth Factor 1 / pharmacology; Fibroblast Growth Factor 2 / genetics; Fibroblast Growth Factor 2 / pharmacology; Gene Expression / drug effects; Heparin / pharmacology; Pulmonary Alveoli / cytology; Pulmonary Alveoli / drug effects; Pulmonary Alveoli / physiology; Rats; Rats, Inbred F344; Receptor Protein-Tyrosine Kinases / drug effects; Receptor Protein-Tyrosine Kinases / genetics; Receptor, Fibroblast Growth Factor, Type 1; Receptor, Fibroblast Growth Factor, Type 2; Receptors, Fibroblast Growth Factor / drug effects; Receptors, Fibroblast Growth Factor / genetics; Thymidine / metabolism
Source: Web Of Science
Added: August 6, 2018

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