Works (32)
Updated: July 5th, 2023 21:18
2010 journal article
Group-specific comparison of four lactobacilli isolated from human sources using differential blast analysis
GENES AND NUTRITION, 6(3), 319–340.
author keywords: In silico analysis; PAU; Adhesion; Stress response; Bacteriophage
TL;DR:
A comparative genomic analysis of four completely sequenced Lactobacillus strains, isolated from the human gastrointestinal tract, versus 25 lactic acid bacterial genomes present in the public database at the time of analysis.
(via Semantic Scholar)
open access via link.springer.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 patent
Compositions comprising promoter sequences and methods of use
Source: NC State University Libraries
Added: August 6, 2018
2009 patent
Lactobacillus acidophillus nucleic acid sequences encoding cell surface protein homologues and uses therefore
Source: NC State University Libraries
Added: August 6, 2018
2009 patent
Lactobacillus acidophilus nucleic acid sequences encoding stress-related proteins and uses therefor
Source: NC State University Libraries
Added: August 6, 2018
2009 patent
Nucleic acid sequences encoding two-component sensing and regulatory proteins, antimicrobial proteins and uses therefor
Source: NC State University Libraries
Added: August 6, 2018
2008 article
Analysis of the genome sequence of Lactobacillus gasseri ATCC 33323 reveals the molecular basis of an autochthonous intestinal organism
Azcarate-Peril, M. A., Altermann, E., Goh, Y. J., Tallon, R., Sanozky-Dawes, R. B., Pfeiler, E. A., … Klaenhammer, T. R. (2008, August). APPLIED AND ENVIRONMENTAL MICROBIOLOGY, Vol. 74, pp. 4610–4625.
MeSH headings : Adult; Bacterial Adhesion / genetics; Bacterial Adhesion / physiology; Bacterial Proteins / genetics; Child; DNA Primers; Gastrointestinal Tract / microbiology; Genes, Bacterial; Genome, Bacterial; Humans; Infant, Newborn; Intestines / microbiology; Lactobacillus / genetics; Lactobacillus / isolation & purification; Lactobacillus / pathogenicity; Open Reading Frames
TL;DR:
The results from this study indicated high intraspecies variability from a genome encoding traits important for survival and retention in the gastrointestinal tract.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
15. Life on Land
(OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2008 article
Functional genomics of probiotic Lactobacilli
Klaenhammer, T. R., Altermann, E., Pfeiler, E., Buck, B. L., Goh, Y.-J., O'Flaherty, S., … Duong, T. (2008, September). JOURNAL OF CLINICAL GASTROENTEROLOGY, Vol. 42, pp. S160–S162.
author keywords: Lactobacillus acidophilus; Lactobacillus johnsonii; Lactobacillus plantarum; Lactobacillus gasseri; genomics; probiotic cultures; lactic acid bacteria
MeSH headings : Animals; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Evolution, Molecular; Genome, Bacterial; Genomics; Humans; Lactobacillus / classification; Lactobacillus / genetics; Lactobacillus / metabolism; Lactobacillus / physiology; Probiotics / metabolism; Species Specificity
TL;DR:
A comparative genomic analysis of 4 completely sequenced Lactobacillus strains versus 25 lactic acid bacterial genomes present in the public database at thetime of analysis is conducted.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2008 patent
Lactobacillus acidophilus nucleic acid sequences encoding carbohydrate utilization-related proteins and uses therefor
Source: NC State University Libraries
Added: August 6, 2018
2008 patent
Lactobacillus acidophilus nucleic acid sequences encoding cell surface protein homologues and uses therefore
Washington, DC: U.S. Patent and Trademark Office.
Source: NC State University Libraries
Added: August 6, 2018
2008 patent
Lactobacillus acidophilus nucleic acid sequences encoding protease homologues and uses therefore
Source: NC State University Libraries
Added: August 6, 2018
2008 patent
Lactobacillus acidophilus nucleic acids and uses thereof
Source: NC State University Libraries
Added: August 6, 2018
2008 journal article
S layer protein A of Lactobacillus acidophilus NCFM regulates immature dendritic cell and T cell functions
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 105(49), 19474–19479.
author keywords: lactobacilli; DC-SIGN
MeSH headings : Bacterial Proteins / genetics; Bacterial Proteins / immunology; Bacterial Proteins / metabolism; Cell Differentiation / immunology; Cell Line; Cytokines / metabolism; Dendritic Cells / immunology; Dendritic Cells / microbiology; Immune Tolerance / immunology; Kidney / cytology; Lactobacillus acidophilus / genetics; Lactobacillus acidophilus / immunology; Lactobacillus acidophilus / metabolism; Macrophages / immunology; Macrophages / microbiology; Membrane Glycoproteins / genetics; Membrane Glycoproteins / immunology; Membrane Glycoproteins / metabolism; Mutagenesis; Probiotics; T-Lymphocytes / immunology; T-Lymphocytes / microbiology; Toll-Like Receptor 2 / genetics; Toll-Like Receptor 2 / metabolism; Toll-Like Receptor 4 / genetics; Toll-Like Receptor 4 / metabolism; Transfection
TL;DR:
The major S layer protein, SlpA, of L. acidophilus NCFM is the first probiotic bacterial DC-SIGN ligand identified that is functionally involved in the modulation of DCs and T cells functions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2007 article
Influence of the dairy environment on gene expression and substrate(1-3)
Klaenhammer, T. R., Azcarate-Peril, M. A., Altermann, E., & Barrangou, R. (2007, March). JOURNAL OF NUTRITION, Vol. 137, pp. 748S–750S.
MeSH headings : Animals; Cattle; Dairy Products; Dairying; Environment; Gene Expression Regulation, Bacterial; Lactobacillaceae / genetics; Lactobacillaceae / metabolism; Probiotics
TL;DR:
Comparative genomics between multiple genomes is providing insights into genes that are important in metabolic, physiological, and functional roles for different LAB in the environments they inhabit, ranging from the gastrointestinal tract to milk and acidified dairy products.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2006 journal article
Comparative genomics and transcriptional analysis of prophages identified in the Genomes of Lactobacillus gasseri, Lactobacillus salivarius, and Lactobacillus casei
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 72(5), 3130–3146.
MeSH headings : Animals; Base Sequence; Genome, Bacterial; Genome, Viral; Genomics; Humans; Lactobacillus / genetics; Lactobacillus / virology; Lacticaseibacillus casei / virology; Molecular Sequence Data; Phylogeny; Prophages / classification; Prophages / genetics; Prophages / isolation & purification; Prophages / metabolism; Sequence Analysis, DNA; Siphoviridae / classification; Siphoviridae / genetics; Siphoviridae / isolation & purification; Siphoviridae / metabolism; Transcription, Genetic; Viral Proteins / genetics; Viral Proteins / metabolism
TL;DR:
Phylogenetic investigation of these newly described prophage sequences revealed that they have not followed an evolutionary development similar to that of their bacterial hosts and that they show a high degree of diversity, even within a species.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2006 journal article
Comparative genomics of the lactic acid bacteria
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 103(42), 15611–15616.
author keywords: evolutionary genomics; fermentation
MeSH headings : Animals; Bacterial Proteins / classification; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Biological Evolution; Food Microbiology; Gene Transfer, Horizontal; Genome, Bacterial; Genomics; Lactic Acid / metabolism; Lactobacillus / classification; Lactobacillus / genetics; Phylogeny; Streptococcaceae / classification; Streptococcaceae / genetics
TL;DR:
Phylogenetic analyses, comparison of gene content across the group, and reconstruction of ancestral gene sets indicate a combination of extensive gene loss and key gene acquisitions via horizontal gene transfer during the coevolution of lactic acid bacteria with their habitats.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2005 journal article
Complete genome sequence of the probiotic lactic acid bacterium Lactobacillus acidophilus NCFM
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 102(11), 3906–3912.
author keywords: adhesion; stress response; proteolytic system; sugar metabolism; in silico analysis
MeSH headings : Bacterial Adhesion / genetics; Bacteriocins / genetics; Bacteriophages / genetics; Bacteriophages / pathogenicity; Carbohydrate Metabolism; Computational Biology; Genome, Bacterial; Lactobacillus acidophilus / genetics; Lactobacillus acidophilus / metabolism; Lactobacillus acidophilus / virology; Molecular Sequence Data; Peptide Hydrolases / genetics; Prophages / genetics; Sequence Analysis, DNA; Transposases / genetics
TL;DR:
These features within the genome sequence of L. acidophilus are likely to contribute to the organisms' gastric survival and promote interactions with the intestinal mucosa and microbiota.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2005 journal article
Functional analysis of putative adhesion factors in Lactobacillus acidophilus NCFM
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 71(12), 8344–8351.
MeSH headings : Adhesins, Bacterial / genetics; Adhesins, Bacterial / physiology; Base Sequence; DNA Primers; DNA, Bacterial / genetics; Escherichia coli / genetics; Genome, Bacterial; Lactobacillus acidophilus / classification; Lactobacillus acidophilus / genetics; Lactobacillus acidophilus / physiology; Mucins / metabolism; Phylogeny; Plasmids; Restriction Mapping
TL;DR:
It is demonstrated that multiple cell surface proteins in L. acidophilus NCFM can individually contribute to the organism's ability to attach to intestinal cells in vitro.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2005 journal article
Genomic Perspectives on Probiotic Lactic Acid Bacteria
Bioscience and Microflora, 24(2), 31–33.
TL;DR:
The genomic content of probiotic Lactobacillus cultures is examined, compared to those lactic acid bacterial genomes that have appeared recently, to illustrate how environmental conditions encountered during biomanufacturing, fermentation, and the gastrointestinal tract can impact gene expression and culture functionality.
(via Semantic Scholar)
Sources: NC State University Libraries, ORCID, NC State University Libraries
Added: August 6, 2018
2005 review
Genomic features of lactic acid bacteria effecting bioprocessing and health
[Review of ]. FEMS MICROBIOLOGY REVIEWS, 29(3), 393–409.
author keywords: lactic acid bacteria; genomics; bioprocessing; probiotics; comparative genomics; functional genomics
MeSH headings : Food Microbiology; Genome, Bacterial; Genomics; Health; Humans; Lactobacillus / genetics; Lactobacillus / growth & development; Lactobacillus / physiology; Lactococcus / genetics; Lactococcus / growth & development; Lactococcus / physiology; Probiotics
TL;DR:
Genomic analyses of multiple members of the lactic acid bacteria have now elucidated many genetic features that direct their fermentative and probiotic roles, providing an important platform for understanding core mechanisms that control and regulate bacterial growth, survival, signaling, and fermentative processes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2005 journal article
Microarray analysis of a two-component regulatory system involved in acid resistance and proteolytic activity in Lactobacillus acidophilus
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 71(10), 5794–5804.
MeSH headings : Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Base Sequence; Culture Media; Gene Expression Profiling; Gene Expression Regulation, Bacterial; Histidine Kinase; Hydrogen-Ion Concentration; Lactobacillus acidophilus / genetics; Lactobacillus acidophilus / growth & development; Lactobacillus acidophilus / metabolism; Lactobacillus acidophilus / physiology; Mutation; Oligonucleotide Array Sequence Analysis / methods; Peptide Hydrolases / genetics; Peptide Hydrolases / metabolism; Protein Kinases / genetics; Protein Kinases / metabolism; Signal Transduction
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2005 journal article
PathwayVoyager: pathway mapping using the Kyoto Encyclopedia of Genes and Genomes (KEGG) database
BMC Genomics, 6.
Source: NC State University Libraries
Added: August 6, 2018
2005 journal article
Sequence analysis of the Lactobacillus plantarum bacteriophage Phi JL-1
GENE, 348, 45–54.
author keywords: bacteriophage; Phi JL-1; sequence analysis; structural proteins; Lactobacillus plantarum
MeSH headings : Amino Acid Sequence; Bacteriolysis / genetics; Bacteriophages / genetics; Bacteriophages / ultrastructure; Chromosome Mapping; DNA Replication / genetics; DNA, Viral / chemistry; DNA, Viral / genetics; Genes / genetics; Genome, Viral; Lactobacillus plantarum / virology; Microscopy, Electron; Molecular Sequence Data; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Viral Structural Proteins / genetics; Virus Assembly / genetics
TL;DR:
The structural gene maps revealed that the order of the head and tail genes is highly conserved among the genomes of several Siphoviridae phages, allowing the assignment of probable functions to certain uncharacterized ORFs from phage PhiJL-1 and other Siphaviridaephages.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2004 journal article
Epidemic clone I-specific genetic markers in strains of Listeria monocytogenes serotype 4b from foods
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 70(7), 4158–4164.
MeSH headings : Base Composition; DNA, Bacterial / analysis; Food Microbiology; Genetic Markers; Listeria monocytogenes / classification; Listeria monocytogenes / genetics; Serotyping
TL;DR:
Examination of 34 serogroup 4 (putative or confirmed serotype 4b) isolates of L. monocytogenes obtained from various foods and food-processing environments, without known implication in illness, revealed that many of these strains had methylation of cytosines at GATC sites in the genome, rendering their DNA resistant to digestion by the restriction endonuclease Sau3AI.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2004 article
Epidemic clone I-specific genetic markers in strains of Listeria monocytogenes serotype 4b from foods (vol 70, pg 4158, 2004)
Yildirim, S., Lin, W., Hitchins, A. D., Jaykus, L. A., Altermann, E., Klaenhammer, T. R., & Kathariou, S. (2004, December). APPLIED AND ENVIRONMENTAL MICROBIOLOGY, Vol. 70, pp. 7581–7581.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2004 journal article
Genetic markers unique to Listeria monocytogenes serotype 4b differentiate epidemic clone II (hot dog outbreak strains) from other lineages
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 70(4), 2383–2390.
MeSH headings : Animals; Base Sequence; DNA Primers / genetics; DNA, Bacterial / genetics; Disease Outbreaks; Europe / epidemiology; Food Microbiology; Foodborne Diseases / epidemiology; Foodborne Diseases / microbiology; Genes, Bacterial; Genetic Markers; Humans; Listeria monocytogenes / classification; Listeria monocytogenes / genetics; Listeria monocytogenes / isolation & purification; Listeria monocytogenes / pathogenicity; Meat Products / microbiology; North America / epidemiology; Polymerase Chain Reaction; Serotyping
TL;DR:
The findings suggest that ECII strains have undergone divergence in portions of a serotype-specific region that is conserved in other serotype 4b strains, although the mechanisms that drive this divergence remain to be identified.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2004 journal article
Identification and inactivation of genetic loci involved with Lactobacillus acidophilus acid tolerance
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 70(9), 5315–5322.
MeSH headings : Base Sequence; Calorimetry; DNA Primers; Genome, Bacterial; Hydrogen-Ion Concentration; Lactobacillus acidophilus / genetics; Lactobacillus acidophilus / growth & development; Molecular Sequence Data; Polymerase Chain Reaction; Restriction Mapping
TL;DR:
Interestingly, each integrant also exhibited an adaptive acid response during logarithmic growth, indicating that multiple mechanisms are present and orchestrated in L. acidophilus in response to acid challenge.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2004 journal article
Identification and phenotypic characterization of the cell-division protein CdpA
GENE, 342(1), 189–197.
author keywords: lactic acid bacteria; lactobacillus; cell adhesion; stress tolerance; functional inactivation; cell wall; cell separation
MeSH headings : Bacterial Adhesion / genetics; Bacterial Adhesion / physiology; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Caco-2 Cells; Cell Cycle Proteins / genetics; Cell Division / drug effects; Cell Division / genetics; Cell Division / physiology; Cell Wall / metabolism; Culture Media / pharmacology; DNA, Bacterial / chemistry; DNA, Bacterial / genetics; DNA, Bacterial / isolation & purification; Ethanol / pharmacology; Freezing; Gene Silencing; Humans; Lactobacillus acidophilus / drug effects; Lactobacillus acidophilus / genetics; Lactobacillus acidophilus / growth & development; Membrane Glycoproteins / genetics; Molecular Sequence Data; Mutation; Phylogeny; Sequence Analysis, DNA; Sodium Chloride / pharmacology; Temperature
TL;DR:
It is ascertained that this protein plays a role in cell-wall processing during the growth and cell-cell separation and is designated as cell-division protein, cdpA, based on the in silico and functional analyses.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2004 patent
Lactobacillus acidophilus nucleic acids encoding fructo-oligosaccharide utilization compounds and uses thereof
Washington, DC: U.S. Patent and Trademark Office.
Source: NC State University Libraries
Added: August 6, 2018
2004 journal article
The genome sequence of the probiotic intestinal bacterium Lactobacillus johnsonii NCC 533
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 101(8), 2512–2517.
MeSH headings : Biological Transport; Cell Adhesion; Energy Metabolism; Fimbriae, Bacterial / genetics; Genes, Bacterial / genetics; Genome, Bacterial; Humans; Intestinal Mucosa / microbiology; Lactobacillus / genetics; Lactobacillus / metabolism; Lactobacillus / pathogenicity; Molecular Sequence Data; Operon / genetics
TL;DR:
Genome analysis predicted an abundance of large and unusual cell-surface proteins, including fimbrial subunits, which may be involved in adhesion to glycoproteins or other components of mucin, a characteristic expected to affect persistence in the gastrointestinal tract (GIT).
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2003 journal article
Functional and comparative genomic analyses of an operon involved in fructooligosaccharide utilization by Lactobacillus acidophilus
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 100(15), 8957–8962.
MeSH headings : ATP-Binding Cassette Transporters / genetics; ATP-Binding Cassette Transporters / metabolism; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Base Sequence; Biological Transport, Active; Chromosome Mapping; DNA, Bacterial / genetics; Escherichia coli Proteins / genetics; Escherichia coli Proteins / metabolism; Genome, Bacterial; Lac Repressors; Lactobacillus acidophilus / genetics; Lactobacillus acidophilus / metabolism; Molecular Sequence Data; Multigene Family; Mutation; Oligosaccharides / metabolism; Operon; Phenotype; Phylogeny; Repressor Proteins / genetics; Repressor Proteins / metabolism; Sequence Homology, Nucleic Acid; Species Specificity
TL;DR:
This is a description of a previously undescribed gene locus involved in transport and catabolism of FOS compounds, which can promote competition of beneficial microorganisms in the human gastrointestinal tract.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2003 journal article
Isolation and characterization of a Lactobacillus plantarum bacteriophage, Phi JL-1, from a cucumber fermentation
INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY, 84(2), 225–235.
author keywords: bacteriophage; Lactobacillus plantarum; lactic acid bacteria; vegetable fermentation; cucumber fermentation
MeSH headings : Adsorption; Bacteriophages / genetics; Bacteriophages / isolation & purification; Bacteriophages / physiology; Cucumis sativus / microbiology; Culture Media / chemistry; DNA, Viral / analysis; Electrophoresis, Polyacrylamide Gel; Fermentation; Food Microbiology; Genome, Viral; Hydrogen-Ion Concentration; Kinetics; Lactobacillus / virology
TL;DR:
A virulent Lactobacillus plantarum bacteriophage, PhiJL-1, was isolated from a commercial cucumber fermentation and sequenced to reveal a linear, double-stranded DNA that may be important for the development of controlled vegetable fermentations.
(via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018
2002 journal article
Discovering lactic acid bacteria by genomics
Antonie Van Leeuwenhoek, 82(1-4), 29–58.
MeSH headings : Bifidobacterium / genetics; Fermentation; Genomics; Gram-Positive Bacteria / genetics; Lactobacillus / classification; Lactobacillus / genetics; Lactococcus lactis / classification; Lactococcus lactis / genetics
UN Sustainable Development Goal Categories
15. Life on Land
(OpenAlex)
Source: NC State University Libraries
Added: August 6, 2018
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