@article{yi_hughes-oliver_zhu_young_2002, title={A factorial design to optimize cell-based drug discovery analysis}, volume={42}, ISSN={["0095-2338"]}, DOI={10.1021/ci025509n}, abstractNote={Drug discovery is dependent on finding a very small number of biologically active or potent compounds among millions of compounds stored in chemical collections. Quantitative structure-activity relationships suggest that potency of a compound is highly related to that compound's chemical makeup or structure. To improve the efficiency of cell-based analysis methods for high throughput screening, where information of a compound's structure is used to predict potency, we consider a number of potentially influential factors in the cell-based approach. A fractional factorial design is implemented to evaluate the effects of these factors, and lift chart results show that the design scheme is able to find conditions that enhance hit rates.}, number={5}, journal={JOURNAL OF CHEMICAL INFORMATION AND COMPUTER SCIENCES}, author={Yi, BM and Hughes-Oliver, JM and Zhu, L and Young, SS}, year={2002}, pages={1221–1229} }