Thymocyte and Peripheral Blood T Lymphocyte Subpopulation Changes in Piglets Following in Utero Infection with Porcine Reproductive and Respiratory Syndrome Virus
Feng, W.-hai, Tompkins, M. B., Xu, J.-S., Brown, T. T., Laster, S. M., Zhang, H.-xiao, & McCaw, M. B. (2002, October 1). Virology.
author keywords: PRRSV; thymus; thymocyte; T lymphocyte
MeSH headings : Animals; Animals, Newborn; Female; Infectious Disease Transmission, Vertical; Leukocytes, Mononuclear / immunology; Lymphocyte Count; Porcine Reproductive and Respiratory Syndrome / immunology; Porcine Reproductive and Respiratory Syndrome / virology; Porcine respiratory and reproductive syndrome virus / immunology; Pregnancy; Pregnancy, Animal; Swine; Swine Diseases / immunology; Swine Diseases / virology; T-Lymphocyte Subsets / immunology; Thymus Gland / cytology; Thymus Gland / immunology; Uterus / virology
topics (OpenAlex): Animal Virus Infections Studies; Viral gastroenteritis research and epidemiology; Virus-based gene therapy research
TL;DR:
It is shown that the number of thymocytes undergoing apoptosis was increased twofold in piglets infected with PRRSV and this results help explain the dramatic immunosuppression observed in neonatal animals infected in utero withPRRSV.
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