Works (3)
Updated: July 5th, 2023 15:59
2005 journal article
Plasma and interstitial fluid pharmacokinetics of enrofloxacin, its metabolite ciprofloxacin, and marbofloxacin after oral administration and a constant rate intravenous infusion in dogs
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 28(4), 329–341.
MeSH headings : Administration, Oral; Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / pharmacokinetics; Area Under Curve; Ciprofloxacin / administration & dosage; Ciprofloxacin / blood; Ciprofloxacin / pharmacokinetics; Cross-Over Studies; Dogs / metabolism; Enrofloxacin; Extracellular Fluid / metabolism; Female; Fluoroquinolones / administration & dosage; Fluoroquinolones / blood; Fluoroquinolones / pharmacokinetics; Infusions, Intravenous / veterinary; Quinolones / administration & dosage; Quinolones / blood; Quinolones / pharmacokinetics
TL;DR:
The ISF and plasma-unbound concentrations were similar during the steady-state period despite differences in lipophilicity and pharmacokinetic parameters of the drugs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2003 journal article
Comparison of plasma and interstitial fluid concentrations of doxycycline and meropenem following constant rate intravenous infusion in dogs
AMERICAN JOURNAL OF VETERINARY RESEARCH, 64(8), 1040–1046.
MeSH headings : Animals; Area Under Curve; Cross-Over Studies; Dogs / blood; Dogs / metabolism; Doxycycline / administration & dosage; Doxycycline / blood; Doxycycline / pharmacokinetics; Extracellular Space; Female; Half-Life; Injections, Intravenous; Male; Meropenem; Protein Binding; Thienamycins / administration & dosage; Thienamycins / blood; Thienamycins / pharmacokinetics
TL;DR:
The extent of protein binding determines distribution of doxycycline and meropenem into ISF, and as a result of high protein binding, ISF doxycyine concentrations are lower than plasma total doxy cycline concentrations.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2002 article
Plasma pharmacokinetics and tissue fluid concentrations of meropenem after intravenous and subcutaneous administration in dogs
Bidgood, T., & Papich, M. G. (2002, December). AMERICAN JOURNAL OF VETERINARY RESEARCH, Vol. 63, pp. 1622–1628.
MeSH headings : Animals; Area Under Curve; Cross-Over Studies; Dogs / blood; Dogs / metabolism; Extracellular Space / chemistry; Female; Half-Life; Injections, Intravenous / veterinary; Injections, Subcutaneous / veterinary; Meropenem; Protein Binding / physiology; Random Allocation; Thienamycins / blood; Thienamycins / pharmacokinetics; Thienamycins / urine; Ultrafiltration / veterinary
TL;DR:
Analysis of the data revealed that tissue fluid and plasma (unbound fraction) concentrations were similar, and because of the kinetic similarity of meropenem in the extravascular and vascular spaces, tissue fluid concentrations can be predicted from plasma concentrations.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
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