@article{burkhard_valenski_leavell_dean_tompkins_2002, title={Evaluation of FIV protein-expressing VEE-replicon vaccine vectors in cats}, DOI={10.1016/S0264-410X(02)00455-3}, abstractNote={Venezuelan equine encephalitis (VEE) virus-replicon particles (VRP) were used to generate feline immunodeficiency virus (FIV) Gag- and ENV-expressing vaccine vectors. Serum and mucosal FIV-specific antibody was detected in cats immunized subcutaneously, once monthly for 5 months, with FIV-expressing VRP. Expansion of the CD8+ L-selectin negative phenotype and transient CD8+ noncytolytic suppressor activity were seen in cats immunized with FIV-expressing or control VRP. Despite induction of FIV-specific immune responses and nonspecific suppressor responses, all cats became infected following vaginal challenge with high dose, pathogenic cell-associated FIV-NCSU(1) although relative early maintenance of CD4+ cells was seen in FIV-immunized cats.}, number={3-4}, journal={Vaccine}, author={Burkhard, Mary Jo and Valenski, Loretta and Leavell, Sarah and Dean, Gregg A and Tompkins, Wayne A.F}, year={2002}, month={Dec} }