@article{yoon_zhu_ewing_smart_2007, title={Decreased survival of C/EBP beta-deficient keratinocytes is due to aberrant regulation of p53 levels and function}, volume={26}, ISSN={["1476-5594"]}, DOI={10.1038/sj.onc.1209797}, abstractNote={Recent studies have identified roles for C/EBPbeta in cellular survival and tumorigenesis, however, the mechanisms through which C/EBPbeta regulates these processes are not fully understood. Previously, we demonstrated that C/EBPbeta(-/-) mice are resistant to carcinogen-induced skin tumorigenesis and in response to topical carcinogen treatment display a 17-fold increase in keratinocyte apoptosis compared to wild-type mice. Here, we have investigated the mechanisms through which C/EBPbeta regulates apoptosis in response to carcinogenic stress. Analysis of carcinogen-treated C/EBPbeta(-/-) mouse skin revealed a striking increase in the number of p53 immunopositive keratinocytes in the epidermis of C/EBPbeta(-/-) mice compared to wild-type mice and this increase was temporally associated with a concomitant anomalous increase in apoptosis. The increased levels of p53 were functional as Mdm2, Bcl-2, C/EBPalpha and p21 were differentially regulated in the epidermis of carcinogen-treated C/EBPbeta(-/-) mice. The increase in p53 protein was not associated with an increase in p53 mRNA levels. To determine whether p53 is required for the increased apoptosis in C/EBPbeta(-/-) mice, C/EBPbeta/p53 compound knockout mice were generated. Carcinogen-treated C/EBPbeta/p53 compound knockout mice did not display increased apoptosis demonstrating p53 is required for the proapoptotic phenotype in C/EBPbeta(-/-) mice. Our results demonstrate that altered keratinocyte survival in C/EBPbeta(-/-) mice results from aberrant regulation of p53 protein and function and indicate C/EBPbeta has a role in the negative regulation of p53 protein levels in response to carcinogen-induced stress.}, number={3}, journal={ONCOGENE}, author={Yoon, K. and Zhu, S. and Ewing, S. J. and Smart, R. C.}, year={2007}, month={Jan}, pages={360–367} }
 @article{zhu_chang_kadla_2003, title={A new method for the preparation of peroxymonophosphoric acid}, volume={81}, ISSN={["1480-3291"]}, DOI={10.1139/V03-010}, abstractNote={ A new method for the preparation of peroxymonophosphoric acid (H3PO5) has been developed. It utilizes a biphasic solution to moderate the vigorous reaction between phosphorous pentoxide (P2O5) and hydrogen peroxide (H2O2). P2O5 is suspended in carbon tetrachloride (CCl4), and concentrated H2O2 is slowly added while being vigorously stirred at low temperature. Careful control of the reaction temperature through the slow addition of H2O2 is critical. Using typical preparation conditions (P2O5:H2O2 = 0.5:1, H2O2 70 wt %, 2°C, 120–180 min), ~70% of the H2O2 is effectively converted to H3PO5. Increasing the concentration of H2O2, as well as the mole ratio of P2O5:H2O2, leads to an even higher % conversion of H2O2 to H3PO5. The addition of glacial acetic acid to the P2O5:H2O2 suspension at the end of the 120–180 min reaction (P2O5:H2O2:CH3COOH = 0.5:1:0.3) leads to the formation of peracetic acid in addition to H3PO5, and to an overall increase in the conversion ratio of total peroxy acids based on H2O2 (>95%).Key words: peroxymonophosphoric acid, synthesis, stability, conversion ratio. }, number={2}, journal={CANADIAN JOURNAL OF CHEMISTRY}, author={Zhu, T and Chang, HM and Kadla, JF}, year={2003}, month={Feb}, pages={156–160} }
 @article{zhu_kadla_chang_jameel_2003, title={Reactions of lignin with peroxymonophosphoric acid: The degradation of lignin model compounds}, volume={57}, ISSN={["0018-3830"]}, DOI={10.1515/HF.2003.007}, abstractNote={Summary}, number={1}, journal={HOLZFORSCHUNG}, author={Zhu, T and Kadla, JF and Chang, HM and Jameel, H}, year={2003}, pages={44–51} }