Leslie M. Tompkins

Works (3)

Updated: July 5th, 2023 15:59

2008 journal article

Unique transcription start sites and distinct promoter regions differentiate the pregnane X receptor (PXR) isoforms PXR 1 and PXR 2

DRUG METABOLISM AND DISPOSITION, 36(5), 923–929.

By: L. Tompkins*, T. Sit*  & A. Wallace*

Contributors: L. Tompkins*, T. Sit*  & A. Wallace*

MeSH headings : Cell Line, Tumor; Cytochrome P-450 CYP3A / genetics; Gene Expression; Humans; Liver / metabolism; Pregnane X Receptor; Promoter Regions, Genetic; Protein Isoforms / genetics; RNA, Messenger / metabolism; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid / genetics; Reverse Transcriptase Polymerase Chain Reaction; Transcription Initiation Site; Transfection
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2007 journal article

Mechanisms of cytochrome P450 induction

Journal of Biochemical and Molecular Toxicology, 21(4), 176–181.

By: L. Tompkins & A. Wallace

Source: NC State University Libraries
Added: August 6, 2018

2003 article

Modulation of fibroblast growth factor expression and signal transduction in type II cells

Li, C. M., Newman, D., Cesta, M., Tompkins, L., Khosla, J., & Sannes, P. L. (2003, March). CHEST, Vol. 123, pp. 429S–429S.

By: C. Li n, D. Newman n, M. Cesta n, L. Tompkins n, J. Khosla n & P. Sannes n

MeSH headings : Antigenic Modulation / genetics; Antigenic Modulation / immunology; Asthma / genetics; Asthma / immunology; Epithelial Cells / immunology; Fibroblast Growth Factors / genetics; Fibroblast Growth Factors / immunology; Gene Expression / genetics; Gene Expression / immunology; Humans; In Vitro Techniques; Signal Transduction / genetics; Signal Transduction / immunology
TL;DR: The data suggests that airway fibroblasts from severe asthmatics may be of a synthetic phenotype, with altered capabilities in collagen production, as compared to those from patients with mild-to-moderate asthma and normal control subjects, and this may be driven by an increased expression of PDGFR. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

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