Alexander G. Tkachenko

Works (5)

Updated: November 3rd, 2025 23:44

2008 patent

Nanoparticle delivery vehicle

Washington, DC: U.S. Patent and Trademark Office.

By: S. Franzen , D. Feldheim, A. Tkachenko, M. Godek, J. Ryan & M. Anderson

Source: NC State University Libraries
Added: August 6, 2018

2006 article

Mimicking the biological activity of diazobenzo[b]fluorene natural products with electronically tuned diazofluorene analogs

Zeng, W., Ballard, T. E., Tkachenko, A. G., Burns, V. A., Feldheim, D. L., & Melander, C. (2006, July 26). Bioorganic & Medicinal Chemistry Letters.

By: W. Zeng n, T. Ballard n, A. Tkachenko n, V. Burns n, D. Feldheim n & C. Melander n

author keywords: kinamycins; lomaiviticins; DNA cleavage; diazofluorenes; antiproliferative activity
MeSH headings : Animals; Antineoplastic Agents / chemical synthesis; Antineoplastic Agents / pharmacology; Carbazoles / pharmacology; Cell Proliferation / drug effects; DNA Damage / drug effects; Fluorenes / chemical synthesis; Fluorenes / pharmacology; HeLa Cells; Humans; Molecular Mimicry; Structure-Activity Relationship
topics (OpenAlex): Organic Chemistry Cycloaddition Reactions; Click Chemistry and Applications; Fluorine in Organic Chemistry
TL;DR: Under appropriate electronic modulation, simple diazofluorene analogs recapitulate the DNA cleavage activity of kinamycin D under thiol-based reducing conditions, key to anticancer activity. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2004 article

Cellular Trajectories of Peptide-Modified Gold Particle Complexes:  Comparison of Nuclear Localization Signals and Peptide Transduction Domains

Tkachenko, A. G., Xie, H., Liu, Y., Coleman, D., Ryan, J., Glomm, W. R., … Feldheim, D. L. (2004, April 28). Bioconjugate Chemistry.

By: A. Tkachenko n, H. Xie n, Y. Liu n, D. Coleman n, J. Ryan n, W. Glomm n, M. Shipton n, S. Franzen n , D. Feldheim n

MeSH headings : 3T3 Cells; Animals; Biological Transport, Active / physiology; Cell Line, Tumor; Cell Nucleus / drug effects; Cell Nucleus / metabolism; Gene Products, tat / chemistry; Gold / chemistry; Gold / pharmacokinetics; HeLa Cells; Humans; Macromolecular Substances; Mice; Nuclear Localization Signals / drug effects; Nuclear Localization Signals / metabolism; Peptides / chemistry; Peptides / pharmacokinetics; Protein Structure, Tertiary / physiology; Serum Albumin, Bovine / chemistry; Serum Albumin, Bovine / pharmacokinetics; Temperature; Transduction, Genetic
topics (OpenAlex): RNA Interference and Gene Delivery; Advanced biosensing and bioanalysis techniques; Immunotherapy and Immune Responses
TL;DR: Video-enhanced color differential interference contrast microscopy and transmission electron microscopy indicated that transport of nanoparticles into the cytoplasm and nucleus depends on peptide sequence and cell line, and cellular uptake of Tat PTD peptide-gold nanoparticle conjugates was temperature dependent, suggesting an endosomal pathway of uptake. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2004 article

Preparation of Protein Gradients through the Controlled Deposition of Protein−Nanoparticle Conjugates onto Functionalized Surfaces

Krämer, S., Xie, H., Gaff, J., Williamson, J. R., Tkachenko, A. G., Nouri, N., … Feldheim, D. L. (2004, April 1). Journal of the American Chemical Society.

By: S. Krämer n, H. Xie n, J. Gaff n, J. Williamson n, A. Tkachenko n, N. Nouri n, D. Feldheim  n, D. Feldheim n

MeSH headings : Animals; Axons / drug effects; Axons / physiology; Cattle; Cell Division / drug effects; Cells, Cultured; Chromatography, High Pressure Liquid; Gold Colloid / chemistry; Gold Colloid / pharmacology; Hippocampus / cytology; Metals / chemistry; Microscopy, Fluorescence; Nanotechnology; Neurons / cytology; Neurons / drug effects; Polylysine / chemistry; Rats; Serum Albumin, Bovine / chemistry; Serum Albumin, Bovine / pharmacology; Spectrophotometry
topics (OpenAlex): Nanofabrication and Lithography Techniques; Monoclonal and Polyclonal Antibodies Research; Biochemical and Structural Characterization
TL;DR: Surfaces patterned with proteins using the procedures described within are shown to support cell growth and are thus suitable for studies of protein-cell interactions. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2003 article

Critical Flocculation Concentrations, Binding Isotherms, and Ligand Exchange Properties of Peptide-Modified Gold Nanoparticles Studied by UV−Visible, Fluorescence, and Time-Correlated Single Photon Counting Spectroscopies

Xie, H., Tkachenko, A. G., Glomm, W. R., Ryan, J. A., Brennaman, M. K., Papanikolas, J. M., … Feldheim, D. L. (2003, September 30). Analytical Chemistry.

By: H. Xie n, A. Tkachenko n, W. Glomm n, J. Ryan n, M. Brennaman  n, J. Papanikolas  n, S. Franzen n, D. Feldheim n

MeSH headings : 2,2'-Dipyridyl / analogs & derivatives; 2,2'-Dipyridyl / chemistry; Amino Acid Sequence; Animals; Binding, Competitive; Cattle; Coordination Complexes; Dithionitrobenzoic Acid / chemistry; Flocculation; Fluorescamine / chemistry; Glutathione / chemistry; Gold Colloid / chemistry; Gold Colloid / metabolism; Kinetics; Ligands; Nanotechnology / methods; Particle Size; Peptides / chemistry; Protein Binding; Rhodamines / chemistry; Serum Albumin, Bovine / chemistry; Serum Albumin, Bovine / metabolism; Spectrometry, Fluorescence; Spectrophotometry; Spectrophotometry, Ultraviolet; Succinimides / chemistry; Sulfhydryl Compounds / chemistry
topics (OpenAlex): Gold and Silver Nanoparticles Synthesis and Applications; Analytical chemistry methods development; Mass Spectrometry Techniques and Applications
TL;DR: Protocols for modifying gold nanoparticles with peptide-bovine serum albumin (BSA) conjugates are described within and TCSPC has proven to be a powerful technique for observing the microenvironment of protein-gold nanoparticle conjugacy. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

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