Works (6)
Updated: July 5th, 2023 15:58
2008 patent
Nanoparticle delivery vehicle
Washington, DC: U.S. Patent and Trademark Office.
Source: NC State University Libraries
Added: August 6, 2018
2006 journal article
Mimicking the biological activity of diazobenzo[b]fluorene natural products with electronically tuned diazofluorene analogs
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 16(19), 5148–5151.
author keywords: kinamycins; lomaiviticins; DNA cleavage; diazofluorenes; antiproliferative activity
MeSH headings : Animals; Antineoplastic Agents / chemical synthesis; Antineoplastic Agents / pharmacology; Carbazoles / pharmacology; Cell Proliferation / drug effects; DNA Damage / drug effects; Fluorenes / chemical synthesis; Fluorenes / pharmacology; HeLa Cells; Humans; Molecular Mimicry; Structure-Activity Relationship
TL;DR:
Under appropriate electronic modulation, simple diazofluorene analogs recapitulate the DNA cleavage activity of kinamycin D under thiol-based reducing conditions, key to anticancer activity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2006 journal article
RNA-mediated synthesis of palladium nanoparticles on Au surfaces
LANGMUIR, 22(13), 5862–5866.
MeSH headings : Base Sequence; Gold / chemistry; In Vitro Techniques; Metal Nanoparticles / chemistry; Metal Nanoparticles / ultrastructure; Microscopy, Electron, Scanning; Nucleic Acid Conformation; Palladium / chemistry; RNA, Catalytic / chemistry; RNA, Catalytic / metabolism; Surface Properties
TL;DR:
The use of surface-bound RNA as a tool for directing the orthogonal synthesis of materials on surfaces was demonstrated and it was suggested that a single RNA molecule may be sufficient for nucleating and controlling the shapes of these particles.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2004 journal article
Cellular trajectories of peptide-modified gold particle complexes: Comparison of nuclear localization signals and peptide transduction domains
BIOCONJUGATE CHEMISTRY, 15(3), 482–490.
MeSH headings : 3T3 Cells; Animals; Biological Transport, Active / physiology; Cell Line, Tumor; Cell Nucleus / drug effects; Cell Nucleus / metabolism; Gene Products, tat / chemistry; Gold / chemistry; Gold / pharmacokinetics; HeLa Cells; Humans; Macromolecular Substances; Mice; Nuclear Localization Signals / drug effects; Nuclear Localization Signals / metabolism; Peptides / chemistry; Peptides / pharmacokinetics; Protein Structure, Tertiary / physiology; Serum Albumin, Bovine / chemistry; Serum Albumin, Bovine / pharmacokinetics; Temperature; Transduction, Genetic
TL;DR:
Video-enhanced color differential interference contrast microscopy and transmission electron microscopy indicated that transport of nanoparticles into the cytoplasm and nucleus depends on peptide sequence and cell line, and cellular uptake of Tat PTD peptide-gold nanoparticle conjugates was temperature dependent, suggesting an endosomal pathway of uptake.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2004 journal article
Preparation of protein gradients through the controlled deposition of protein-nanoparticle conjugates onto functionalized surfaces
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 126(17), 5388–5395.
MeSH headings : Animals; Axons / drug effects; Axons / physiology; Cattle; Cell Division / drug effects; Cells, Cultured; Chromatography, High Pressure Liquid; Gold Colloid / chemistry; Gold Colloid / pharmacology; Hippocampus / cytology; Metals / chemistry; Microscopy, Fluorescence; Nanotechnology; Neurons / cytology; Neurons / drug effects; Polylysine / chemistry; Rats; Serum Albumin, Bovine / chemistry; Serum Albumin, Bovine / pharmacology; Spectrophotometry
TL;DR:
Surfaces patterned with proteins using the procedures described within are shown to support cell growth and are thus suitable for studies of protein-cell interactions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2003 journal article
Critical flocculation concentrations, binding isotherms, and ligand exchange properties of peptide-modified gold nanoparticles studied by UV-visible, fluorescence, and time-correlated single photon counting spectroscopies
ANALYTICAL CHEMISTRY, 75(21), 5797–5805.
MeSH headings : 2,2'-Dipyridyl / analogs & derivatives; 2,2'-Dipyridyl / chemistry; Amino Acid Sequence; Animals; Binding, Competitive; Cattle; Coordination Complexes; Dithionitrobenzoic Acid / chemistry; Flocculation; Fluorescamine / chemistry; Glutathione / chemistry; Gold Colloid / chemistry; Gold Colloid / metabolism; Kinetics; Ligands; Nanotechnology / methods; Particle Size; Peptides / chemistry; Protein Binding; Rhodamines / chemistry; Serum Albumin, Bovine / chemistry; Serum Albumin, Bovine / metabolism; Spectrometry, Fluorescence; Spectrophotometry; Spectrophotometry, Ultraviolet; Succinimides / chemistry; Sulfhydryl Compounds / chemistry
TL;DR:
Protocols for modifying gold nanoparticles with peptide-bovine serum albumin (BSA) conjugates are described within and TCSPC has proven to be a powerful technique for observing the microenvironment of protein-gold nanoparticle conjugacy.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
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