Xinxin Zhang

Works (9)

Updated: July 5th, 2023 15:59

2019 article

A Novel Porcine Model for the Study of Cerebrospinal Fluid Dynamics: Development and Preliminary Results

Fleischman, D., Kaskar, O., Shams, R., Zhang, X., Olson, D., Zdanski, C., … Lee, Y. Z. (2019, October 23). Frontiers in Neurology.

By: D. Fleischman *, O. Kaskar n, R. Shams *, X. Zhang*, D. Olson *, C. Zdanski *, B. Thorp*, A. Kuznetsov n, L. Grace n, Y. Lee *

author keywords: CSF; CSF pressure; optic canal; glaucoma; papilledema; space-flight associated neuro-ocular syndrome
topics (OpenAlex): Cerebral Venous Sinus Thrombosis; Ophthalmology and Eye Disorders; Cerebrospinal fluid and hydrocephalus
TL;DR: To investigate CSF flow within the orbit, a model for CSF dynamics was created using three medium-sized pigs and head tilting was performed to highlight the role of gravitational dependence within the subarachnoid space. (via Semantic Scholar)
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Source: Web Of Science
Added: November 18, 2019

2019 article

Extraction and characterization of lignin from corncob residue after acid-catalyzed steam explosion pretreatment

Zhang, X., Zhu, J., Sun, L., Yuan, Q., Cheng, G., & Argyropoulos, D. S. (2019, March 18). Industrial Crops and Products, Vol. 133, pp. 241–249.

By: X. Zhang n, J. Zhu  n, L. Sun, Q. Yuan *, G. Cheng * & D. Argyropoulos n 

author keywords: Biomass; Steam explosion; Corncob; Enzymatic mild acidolysis lignin; NMR; Antioxidant activity
topics (OpenAlex): Lignin and Wood Chemistry; Phytochemicals and Antioxidant Activities; Biochemical and biochemical processes
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6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: July 1, 2019

2012 article

Structurally Conserved Nop56/58 N-terminal Domain Facilitates Archaeal Box C/D Ribonucleoprotein-guided Methyltransferase Activity

Gagnon, K. T., Biswas, S., Zhang, X., Brown, B. A., Wollenzien, P., Mattos, C., & Maxwell, E. S. (2012, April 12). Journal of Biological Chemistry.

By: K. Gagnon n, S. Biswas n, X. Zhang n, B. Brown n, P. Wollenzien n, C. Mattos n, E. Maxwell n

MeSH headings : Archaeal Proteins / chemistry; Archaeal Proteins / genetics; Archaeal Proteins / metabolism; Chromosomal Proteins, Non-Histone / chemistry; Chromosomal Proteins, Non-Histone / genetics; Chromosomal Proteins, Non-Histone / metabolism; Methanococcales / chemistry; Methanococcales / genetics; Methanococcales / metabolism; Methyltransferases / chemistry; Methyltransferases / genetics; Methyltransferases / metabolism; Protein Binding; Protein Structure, Tertiary; Ribonucleoproteins / chemistry; Ribonucleoproteins / genetics; Ribonucleoproteins / metabolism
topics (OpenAlex): RNA modifications and cancer; RNA and protein synthesis mechanisms; Cancer-related gene regulation
TL;DR: The archaeal Nop56/58 NTD exhibits a conserved domain structure whose exceptionally stable interaction with fibrillarin plays a role in both RNP assembly and methyltransferase activity. (via Semantic Scholar)
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15. Life on Land (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2010 article

Structural Basis for Substrate Placement by an Archaeal Box C/D Ribonucleoprotein Particle

Xue, S., Wang, R., Yang, F., Terns, R. M., Terns, M. P., Zhang, X., … Li, H. (2010, September 1). Molecular Cell.

By: S. Xue *, R. Wang *, F. Yang*, R. Terns*, M. Terns *, X. Zhang n, E. Maxwell n, H. Li *

MeSH headings : Archaeal Proteins / chemistry; Archaeal Proteins / genetics; Binding Sites / physiology; Biocatalysis; Chromosomal Proteins, Non-Histone / chemistry; Chromosomal Proteins, Non-Histone / genetics; Chromosomal Proteins, Non-Histone / metabolism; Crystallography, X-Ray; Holoenzymes / chemistry; Holoenzymes / genetics; Holoenzymes / metabolism; Methyltransferases / chemistry; Methyltransferases / genetics; Methyltransferases / metabolism; Models, Molecular; Mutagenesis, Insertional / physiology; Nuclear Proteins / chemistry; Nuclear Proteins / genetics; Nucleic Acid Conformation; Protein Multimerization / physiology; Protein Structure, Quaternary / physiology; Pyrococcus furiosus / enzymology; Pyrococcus furiosus / genetics; RNA, Archaeal / chemistry; RNA, Archaeal / metabolism; RNA, Small Nucleolar / chemistry; Recombinant Proteins / chemistry; Recombinant Proteins / genetics; Ribonucleoproteins, Small Nucleolar / chemistry; Ribonucleoproteins, Small Nucleolar / genetics; Ribonucleoproteins, Small Nucleolar / metabolism; Sequence Deletion / physiology
topics (OpenAlex): RNA and protein synthesis mechanisms; RNA modifications and cancer; Bacterial Genetics and Biotechnology
TL;DR: The predicted asymmetric nature of the holoenzyme is consistent with previous biochemical data on RNP assembly and provides a simple solution for accommodating base-pairing between the C/D guide RNA and large ribosomal and spliceosomal substrate RNAs. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2009 article

Signature amino acids enable the archaeal L7Ae box C/D RNP core protein to recognize and bind the K-loop RNA motif

Gagnon, K. T., Zhang, X., Qu, G., Biswas, S., Suryadi, J., Brown, B. A., & Maxwell, E. S. (2009, November 19). RNA.

By: K. Gagnon n, X. Zhang n, G. Qu n, S. Biswas n, J. Suryadi *, B. Brown n, E. Maxwell n

author keywords: box C/D snoRNA; snoRNP; kink-turn; L7Ae/L30 proteins; RNA-protein interaction
MeSH headings : Amino Acid Motifs / physiology; Amino Acid Sequence; Archaea / genetics; Archaea / metabolism; Archaeal Proteins / chemistry; Archaeal Proteins / genetics; Archaeal Proteins / metabolism; Base Sequence; Binding Sites / genetics; Conserved Sequence; Models, Biological; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Nucleic Acid Conformation; Protein Binding / genetics; RNA, Archaeal / chemistry; RNA, Archaeal / metabolism; Ribonucleoproteins / chemistry; Ribonucleoproteins / genetics; Ribonucleoproteins / metabolism; Sequence Homology, Amino Acid
topics (OpenAlex): RNA and protein synthesis mechanisms; RNA modifications and cancer; RNA Research and Splicing
TL;DR: These five signature amino acids are distinct for each of the L7Ae/L30 family members, suggesting an evolutionary continuum of these RNA-binding proteins for recognition of the various K-turn motifs contained in their cognate RNAs. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2007 article

In Vitro Reconstitution and Affinity Purification of Catalytically Active Archaeal Box C/D sRNP Complexes

Gagnon, K., Zhang, X., & Maxwell, E. S. (2007, January 1). Methods in Enzymology on CD-ROM/Methods in Enzymology.

By: K. Gagnon n, X. Zhang n & E. Maxwell n

MeSH headings : Chromatography, Affinity / methods; Chromatography, Ion Exchange / methods; Methanococcaceae; Ribonucleoproteins, Small Nuclear / isolation & purification
topics (OpenAlex): RNA and protein synthesis mechanisms; RNA modifications and cancer; Bacterial Genetics and Biotechnology
TL;DR: A novel affinity purification scheme that uses differentially tagged core proteins and a sequential three-step affinity selection protocol that yields fully assembled and catalytically active box C/D RNPs. (via Semantic Scholar)
Source: NC State University Libraries
Added: August 6, 2018

2006 article

Assembly of the Archaeal Box C/D sRNP Can Occur via Alternative Pathways and Requires Temperature-facilitated sRNA Remodeling

Gagnon, K. T., Zhang, X., Agris, P. F., & Maxwell, E. S. (2006, August 7). Journal of Molecular Biology.

By: K. Gagnon n, X. Zhang n, P. Agris n & E. Maxwell n

MeSH headings : Amino Acid Sequence; Archaea / chemistry; Archaea / genetics; Archaea / metabolism; Archaeal Proteins / chemistry; Archaeal Proteins / genetics; Archaeal Proteins / isolation & purification; Archaeal Proteins / metabolism; Base Sequence; Chromatography, Affinity; Circular Dichroism; Methylation; Models, Biological; Molecular Sequence Data; Mutation; Nucleic Acid Conformation; Protein Binding; RNA, Archaeal / chemistry; RNA, Archaeal / genetics; RNA, Archaeal / metabolism; RNA, Guide, Kinetoplastida / chemistry; RNA, Guide, Kinetoplastida / genetics; RNA, Guide, Kinetoplastida / metabolism; RNA, Small Nucleolar / chemistry; RNA, Small Nucleolar / genetics; RNA, Small Nucleolar / metabolism; Ribonucleoproteins, Small Nuclear / chemistry; Ribonucleoproteins, Small Nuclear / genetics; Ribonucleoproteins, Small Nuclear / metabolism; Temperature
topics (OpenAlex): RNA modifications and cancer; RNA and protein synthesis mechanisms; Parasitic Infections and Diagnostics
TL;DR: RNA remodeling appears to be a common and requisite feature of archaeal dual-guide box C/D sR NP assembly and formation of the mature sRNP can follow different assembly pathways in generating catalytically active complexes. (via Semantic Scholar)
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Source: NC State University Libraries
Added: August 6, 2018

2005 article

Conserved spacing between the box C/D and C′/D′ RNPs of the archaeal box C/D sRNP complex is required for efficient 2′-O-methylation of target RNAs

TRAN, E. L. I. Z. A. B. E. T. H., ZHANG, X. I. N. X. I. N., LACKEY, L. E. L. A., & MAXWELL, E. S. T. U. A. R. T. (2005, January 20). RNA.

By: E. Tran n, X. Zhang n, L. Lackey n & E. Maxwell n

author keywords: archaeal sRNA; box C/D RNA; box C/D RNP; snoRNA; nucleotide modification
MeSH headings : Archaeal Proteins / metabolism; Base Sequence; DNA Primers; Methylation; Nucleic Acid Conformation; RNA, Archaeal / chemistry; RNA, Archaeal / metabolism; Ribonucleoproteins / metabolism
topics (OpenAlex): RNA modifications and cancer; RNA and protein synthesis mechanisms; Bacteriophages and microbial interactions
TL;DR: The importance of spatially positioning the box C/D and C'/D' RNPs within the sRNP complex for nucleotide modification is investigated for preservation of critical inter-RNP interactions required for efficient box C /D sR NP-guided nucleotide methylation. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2003 article

Efficient RNA 2'-O-methylation requires juxtaposed and symmetrically assembled archaeal box C/D and C'/D' RNPs

Tran, E. J. (2003, July 24). The EMBO Journal.

By: E. Tran n

author keywords: Archaea; box C; D RNP; ribonucleotide methylation; snoRNA; sRNA
MeSH headings : Archaea / metabolism; Archaeal Proteins / chemistry; Archaeal Proteins / metabolism; Base Sequence; Methylation; Molecular Sequence Data; Nucleic Acid Conformation; Protein Binding; RNA, Archaeal / chemistry; RNA, Archaeal / metabolism; Ribonucleoproteins / metabolism
topics (OpenAlex): RNA modifications and cancer; RNA and protein synthesis mechanisms; Genomics and Phylogenetic Studies
TL;DR: In vitro assembly of an archaeal box C/D sRNP using recombinant core proteins L7, Nop56/58 and fibrillarin has yielded an RNA:protein enzyme that guides methylation from both the terminal box C-D core and internal C′/D′ RNP complexes. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

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