Beth McGuire Barlow

Works (16)

Updated: August 3rd, 2023 21:17

2014 journal article

Pharmacokinetics and pharmacodynamics of three formulations of firocoxib in healthy horses

Journal of Veterinary Pharmacology and Therapeutics, 38(3), 249–256.

By: B. Holland n, C. Fogle n , A. Blikslager n , A. Curling n, B. Barlow n, J. Schirmer n, J. Davis n

Contributors: B. Holland n, C. Fogle n , A. Blikslager n , A. Curling n, B. Barlow n, J. Schirmer n, J. Davis n

MeSH headings : 4-Butyrolactone / administration & dosage; 4-Butyrolactone / analogs & derivatives; 4-Butyrolactone / blood; 4-Butyrolactone / pharmacokinetics; 4-Butyrolactone / pharmacology; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal / administration & dosage; Anti-Inflammatory Agents, Non-Steroidal / blood; Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics; Anti-Inflammatory Agents, Non-Steroidal / pharmacology; Cross-Over Studies; Dinoprostone / blood; Horses / metabolism; Injections, Intravenous / veterinary; Ointments; Sulfones / administration & dosage; Sulfones / blood; Sulfones / pharmacokinetics; Sulfones / pharmacology; Tablets; Thromboxane B2 / blood
TL;DR: This study indicates a lack of bioequivalence between the oral formulations of firocoxib when administered as a single dose to healthy horses, as well as a higher Cmax, shorter Tmax, and greater AUC for the paste compared to the tablet. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2014 journal article

Tetracycline Residues in Porcine Stomach after Administration via Drinking Water on a Swine Farm

JOURNAL OF FOOD PROTECTION, 77(1), 122–126.

By: D. Lindquist n, H. Wu *, S. Mason *, J. Yeatts n, J. Brooks n, B. Barlow n, K. Schill n, R. Baynes n 

MeSH headings : Animals; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / pharmacokinetics; Chromatography, High Pressure Liquid / veterinary; Drug Residues / analysis; Europe; Meat / analysis; Monte Carlo Method; Russia; Stomach / chemistry; Swine; Tetracycline / blood; Tetracycline / pharmacokinetics; United States; Water / chemistry
TL;DR: It is demonstrated that tetracycline residues are still detectable in the stomach tissues after the established United States withdrawal time of 4 days, which may explain why stomach tissues tested in Russia and Europe show positive residues for tetrACYcline, even though the meat may pass inspection here in the United States prior to export. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2013 journal article

Effects of quinapril on angiotensin converting enzyme and plasma renin activity as well as pharmacokinetic parameters of quinapril and its active metabolite, quinaprilat, after intravenous and oral administration to mature horses

EQUINE VETERINARY JOURNAL, 46(6), 729–733.

By: J. Davis n, K. Kruger n, D. LaFevers n, B. Barlow n, J. Schirmer n & B. Breuhaus n 

author keywords: horse; angiotensin converting enzyme; renin; mitral insufficiency
MeSH headings : Administration, Intravenous; Administration, Oral; Angiotensin-Converting Enzyme Inhibitors / blood; Angiotensin-Converting Enzyme Inhibitors / metabolism; Angiotensin-Converting Enzyme Inhibitors / pharmacokinetics; Angiotensin-Converting Enzyme Inhibitors / pharmacology; Animals; Area Under Curve; Gene Expression Regulation, Enzymologic; Half-Life; Horses / blood; Horses / metabolism; Peptidyl-Dipeptidase A / blood; Peptidyl-Dipeptidase A / genetics; Peptidyl-Dipeptidase A / metabolism; Quinapril; Renin / blood; Tetrahydroisoquinolines / blood; Tetrahydroisoquinolines / metabolism; Tetrahydroisoquinolines / pharmacokinetics; Tetrahydroisoquinolines / pharmacology
TL;DR: Results suggest that, despite low plasma concentrations, quinapril has sufficient oral absorption to produce inhibition of ACE in healthy horses and provides a potential treatment alternative for horses with cardiovascular and renal disease. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2013 journal article

Pharmacokinetics of tobramycin following intravenous, intramuscular, and intra-articular administration in healthy horses

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 36(6), 532–541.

By: J. Newman n, T. Prange n, S. Jennings n, B. Barlow n & J. Davis n

MeSH headings : Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / pharmacokinetics; Female; Half-Life; Horses / blood; Injections, Intra-Articular; Injections, Intramuscular; Injections, Intravenous; Microbial Sensitivity Tests; Tobramycin / administration & dosage; Tobramycin / blood; Tobramycin / pharmacokinetics
TL;DR: Tobramycin IA resulted in a mild chemical synovitis as evidenced by an increase in synovial fluid cell count and total protein, but appeared to be safe for administration. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Hot topic: Milk and plasma disposition of thymol following intramammary administration of a phytoceutical mastitis treatment

JOURNAL OF DAIRY SCIENCE, 94(4), 1738–1743.

By: C. McPhee n, K. Anderson n, J. Yeatts n, S. Mason*, B. Barlow n & R. Baynes n 

author keywords: Phyto-Mast; organic production; thymol; mastitis treatment
MeSH headings : Angelica sinensis; Animals; Anti-Infective Agents, Local / analysis; Anti-Infective Agents, Local / blood; Anti-Infective Agents, Local / therapeutic use; Dairying / methods; Drug Administration Routes; Drug Residues / analysis; Female; Gaultheria; Glycyrrhiza uralensis; Goats; Mammary Glands, Animal / metabolism; Mastitis / drug therapy; Mastitis / metabolism; Mastitis / veterinary; Milk / chemistry; Phytotherapy / veterinary; Pilot Projects; Thymol / analysis; Thymol / blood; Thymol / therapeutic use; Thymus Plant
TL;DR: This study developed an assay to quantify thymol (one of the active ingredients in Phyto-Mast), a plant-based mastitis treatment used on organic dairy farms, in milk and plasma using gas chromatography and mass spectrometry (GC-MS). (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2011 journal article

Intravenous and sublingual buprenorphine in horses: pharmacokinetics and influence of sampling site

VETERINARY ANAESTHESIA AND ANALGESIA, 38(4), 374–384.

By: K. Messenger  n, J. Davis n, D. LaFevers n, B. Barlow n & L. Posner n

author keywords: analgesia; buprenorphine; equine; opioids; pharmacokinetics; sampling site
MeSH headings : Administration, Sublingual; Analgesics, Opioid / administration & dosage; Analgesics, Opioid / blood; Analgesics, Opioid / pharmacokinetics; Animals; Biological Availability; Blood Chemical Analysis / methods; Blood Chemical Analysis / veterinary; Buprenorphine / administration & dosage; Buprenorphine / analogs & derivatives; Buprenorphine / blood; Buprenorphine / pharmacokinetics; Cross-Over Studies; Horses / metabolism; Injections, Intravenous / veterinary; Jugular Veins; Male; Prospective Studies
TL;DR: Buprenorphine has a long plasma half-life and results in plasma concentrations that are consistent with analgesia in other species for up to 4 hours following IV administration of this dose in horses. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Pharmacokinetics of intravenous and intramuscular buprenorphine in the horse

Journal of Veterinary Pharmacology and Therapeutics, 35(1), 52–58.

By: J. Davis n, K. Messenger*, D. Lafevers*, B. Barlow n & L. Posner*

MeSH headings : Analgesics, Opioid / administration & dosage; Analgesics, Opioid / blood; Analgesics, Opioid / pharmacokinetics; Animals; Area Under Curve; Buprenorphine / administration & dosage; Buprenorphine / blood; Buprenorphine / pharmacokinetics; Cross-Over Studies; Female; Half-Life; Horses / blood; Horses / metabolism; Injections, Intramuscular; Injections, Intravenous; Male
TL;DR: Buprenorphine has a moderate T(1/2) in the horse and was detected at concentrations expected to be therapeutic in other species after i.v. and i.m. administration of 0.005 mg/kg. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Disposition of melamine residues in blood and milk from dairy goats exposed to an oral bolus of melamine

FOOD AND CHEMICAL TOXICOLOGY, 48(8-9), 2542–2546.

By: R. Baynes n , B. Barlow n, S. Mason n & J. Riviere n

author keywords: Triazines; Melamine; Ruminants; Pharmacokinetics
MeSH headings : Animals; Chromatography, High Pressure Liquid; Dairying; Female; Food Contamination; Goats / metabolism; Half-Life; Linear Models; Mass Spectrometry; Milk / chemistry; Tissue Distribution; Triazines / blood; Triazines / pharmacokinetics
TL;DR: The pharmacokinetics of melamine in ruminants is not predictive from monogastrics and milk from similarly exposed animals should be condemned for at least 4days after the last exposure to avoid violation of proposed MRLs or safe levels for milk. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2009 journal article

Elimination kinetics of tilmicosin following intramammary administration in lactating dairy cattle

Journal of the American Veterinary Medical Association, 234(2), 245–248.

By: G. Smith n , J. Davis*, R. Baynes* , J. Yeatts*, B. Barlow* & J. Riviere*

MeSH headings : Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / analysis; Anti-Bacterial Agents / pharmacokinetics; Cattle; Chromatography, High Pressure Liquid / methods; Chromatography, High Pressure Liquid / veterinary; Drug Residues / analysis; Female; Infusions, Parenteral / veterinary; Lactation; Mammary Glands, Animal / metabolism; Mastitis, Bovine / drug therapy; Mastitis, Bovine / metabolism; Metabolic Clearance Rate; Milk / chemistry; Prospective Studies; Tylosin / administration & dosage; Tylosin / analogs & derivatives; Tylosin / analysis; Tylosin / pharmacokinetics
TL;DR: Findings indicated that tilmicosin should not be administered by the intramammary route in lactating dairy cows, and milk from all glands of any cows accidentally treated should be discarded for a minimum of 82 days following intramamsary administration. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2008 journal article

Vehicle effects on in vitro transdermal absorption of sevoflurane in the bullfrog, Rana catesbeiana

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, 25(3), 373–379.

By: A. Ardente n, B. Barlow n, P. Burns *, R. Goldman n & R. Baynes n 

author keywords: amphibian; dermal; sevofluame; in vitro; permeability
TL;DR: The flux-time profiles suggest that sevoflurane diffusion in bullfrog skin may be positively influenced by PLO, and future in vivo studies are required to assess sev ofLurane retention after removal of these formulations to more accurately control the plane of anesthesia in amphibians. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2007 journal article

Partitioning behavior of aromatic components in jet fuel into diverse membrane-coated fibers

JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES, 70(22), 1879–1887.

By: R. Baynes n , X. Xia n, B. Barlow n & J. Riviere n

MeSH headings : 1-Octanol / chemistry; Acrylic Resins / chemistry; Culture Media / chemistry; Dimethylpolysiloxanes / chemistry; Ethanol / chemistry; Humans; Hydrocarbons, Aromatic / chemistry; Hydrocarbons, Aromatic / metabolism; Membranes, Artificial; Models, Biological; Polyethylene Glycols / chemistry; Skin Absorption; Water / chemistry
TL;DR: It is demonstrated that a single or multiple set of MCF fibers may be used as a surrogate for octanol/water systems and skin to assess partitioning behavior of nine aromatic components frequently formulated with jet fuels. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2007 journal article

Pharmacokinetics of melamine in pigs following intravenous administration

Food and Chemical Toxicology, 46(3), 1196–1200.

By: R. Baynes n , G. Smith n , S. Mason n, E. Barrett n, B. Barlow n & J. Riviere n

MeSH headings : Animals; Chromatography, High Pressure Liquid; Infusions, Intravenous; Kidney / metabolism; Sensitivity and Specificity; Spectrophotometry, Ultraviolet; Swine; Triazines / administration & dosage; Triazines / blood; Triazines / pharmacokinetics
TL;DR: The pharmacokinetic parameters for melamine obtained in pigs are comparable to the only mammalian study in rats and suggests that melamine is readily cleared by the kidney and there is unlikely to be significant tissue binding. (via Semantic Scholar)
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018

2006 journal article

Dermatotoxicity of cutting fluid mixtures: In vitro and in vivo studies

CUTANEOUS AND OCULAR TOXICOLOGY, 25(4), 235–247.

By: N. Monteiro-Riviere n , A. Inman n, B. Barlow n & R. Baynes n 

Contributors: N. Monteiro-Riviere n , A. Inman n, B. Barlow n & R. Baynes n 

author keywords: alkylbenzene sulfonate; cutting fluids; HEK; mixtures; ricinoleic acid; triazine; triethanolamine
MeSH headings : Animals; Cell Survival / drug effects; Cells, Cultured; Dermatitis, Contact / etiology; Dermatitis, Contact / metabolism; Dermatitis, Contact / pathology; Dermatitis, Occupational / etiology; Dermatitis, Occupational / metabolism; Dermatitis, Occupational / pathology; Dose-Response Relationship, Drug; Female; Humans; Interleukin-8 / metabolism; Kidney / cytology; Kidney / drug effects; Kidney / embryology; Metallurgy; Mineral Oil / pharmacokinetics; Mineral Oil / toxicity; Occupational Exposure; Skin / drug effects; Skin / metabolism; Skin / pathology; Skin Absorption; Swine
TL;DR: Preliminary studies suggest that the biocide, TRI, is the more potent of the 4 performance additives in causing dermal irritation, and this may vary depending on whether the worker is exposed to a synthetic (PEG)- or MO-based fluid. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2003 journal article

Dermal disposition of triazine in cutting fluid mixtures

JOURNAL OF TOXICOLOGY-CUTANEOUS AND OCULAR TOXICOLOGY, 22(4), 215–229.

By: R. Baynes n , B. Barlow n & J. Riviere n

author keywords: triazine; mixtures; dermal
TL;DR: Assessment of 14C‐triazine membrane transport when topically applied to inert silastic membranes and porcine skin in an in vitro flow‐through diffusion cell system as aqueous mineral oil (MO) or aqueously polyethylene glycol (PEG) mixtures found triazine permeability was significantly enhanced by the complete mixture, especially in PEG‐based mixtures. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2002 journal article

Physicochemical determinants of linear alkylbenzene sulfonate (LAS) disposition in skin exposed to aqueous cutting fluid mixtures

TOXICOLOGY AND INDUSTRIAL HEALTH, 18(5), 237–248.

By: R. Baynes n , J. Brooks n, B. Barlow n & J. Riviere n

author keywords: cutting fluids; LAS; mixtures; physicochemical interactions; skin
MeSH headings : Alkanesulfonic Acids / chemistry; Alkanesulfonic Acids / pharmacokinetics; Alkanesulfonic Acids / toxicity; Animals; Dermatitis, Contact / etiology; Metallurgy; Mineral Oil / pharmacology; Occupational Exposure; Permeability; Polyethylene Glycols / pharmacology; Skin Absorption / drug effects; Solubility; Solvents / pharmacology; Surface-Active Agents / chemistry; Surface-Active Agents / pharmacokinetics; Surface-Active Agents / toxicity; Swine
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

journal article

NDELA and nickel modulation of triazine disposition in skin

Baynes, R. E., Brooks, J. D., Barlow, B. M., & Riviere, J. E. Toxicology and Industrial Health, 21(9), 197–205.

By: R. Baynes , J. Brooks, B. Barlow & J. Riviere

Source: NC State University Libraries
Added: August 6, 2018

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