Ian Christopher Schneider

Works (8)

Updated: July 5th, 2023 15:59

2006 journal article

Effectiveness factor for spatial gradient sensing in living cells

CHEMICAL ENGINEERING SCIENCE, 61(17), 5603–5611.

By: J. Haugh n  & I. Schneider n

author keywords: cellular biology and engineering; kinetics; diffusion; mathematical modeling; chemotaxis; cell migration
TL;DR: It is concluded that the cell morphology and orientation with respect to the gradient can dictate whether messenger diffusion obliterates gradient sensing or has very little effect, and the effect of intracellular messenger diffusion on spatial gradient sensing to be quantified for individual cells. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2006 journal article

Mechanisms of gradient sensing and chemotaxis - Conserved pathways, diverse regulation

CELL CYCLE, 5(11), 1130–1134.

By: I. Schneider n & J. Haugh* 

author keywords: signal transduction; cell migration; phosphoinositide 3-kinase; Rho-family GTPases; mathematical modeling; diffusion; wound healing
MeSH headings : Animals; Chemotactic Factors / physiology; Chemotaxis / physiology; Fibroblasts / cytology; Humans; Wound Healing
TL;DR: This work quantitatively characterized a different gradient sensing system, that of platelet-derived growth factor-stimulated fibroblasts, an important component of dermal wound healing and led us to speculate on the diversity of gradient sensing mechanisms and their biological implications. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2005 journal article

Quantitative elucidation of a distinct spatial gradient-sensing mechanism in fibroblasts

JOURNAL OF CELL BIOLOGY, 171(5), 883–892.

By: I. Schneider n & J. Haugh n 

MeSH headings : 3T3 Cells; Algorithms; Animals; Chemotaxis / physiology; Dictyostelium / cytology; Dictyostelium / physiology; Fibroblasts / physiology; Mice; Models, Biological; Neutrophils / physiology; Phosphatidylinositol 3-Kinases / metabolism; Platelet-Derived Growth Factor / metabolism; Signal Transduction
TL;DR: It is demonstrated that PDGF detection is governed by mechanisms that are fundamentally different from those in D. discoideum and neutrophils, which is consistent with a simpler system lacking the feedback loops that yield signal amplification and adaptation in amoeboid cells. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2005 journal article

Spatial analysis of 3 ' phosphoinositide signaling in living fibroblasts, III: Influence of cell morphology and morphological polarity

BIOPHYSICAL JOURNAL, 89(2), 1420–1430.

By: I. Schneider n, E. Parrish n & J. Haugh n 

MeSH headings : Animals; Cell Polarity / physiology; Cell Size; Kinetics; Metabolic Clearance Rate; Mice; NIH 3T3 Cells; Phosphatidylinositol 3-Kinases / metabolism; Phosphatidylinositols / metabolism; Signal Transduction / physiology
TL;DR: It is found that although the 3' PI pattern is affected by irregular contact area shape, cell morphology alone cannot explain the presence of hot or cold spots, and the morphological polarity of the cell may bias 3'PI signaling to promote persistent migration in fibroblasts. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2004 journal article

On the cross-regulation of protein tyrosine phosphatases and receptor tyrosine kinases in intracellular signaling

JOURNAL OF THEORETICAL BIOLOGY, 230(1), 119–132.

By: J. Haugh n , I. Schneider n & J. Lewis n

author keywords: signal transduction; receptor; phosphatase; kinase; phosphorylation
MeSH headings : Animals; Cell Membrane / metabolism; Models, Biological; Phosphorylation; Protein Tyrosine Phosphatases / metabolism; Signal Transduction / physiology; src-Family Kinases / metabolism
TL;DR: Receptor-PTP binding, in turn, is expected to influence the phosphorylation pattern of those receptors and proteins they associate with, and it is shown how PTPs might serve to co- or counter-regulate parallel pathways in a signaling network. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2004 journal article

Spatial analysis of 3 ' phosphoinositide signaling in living fibroblasts: I. Uniform stimulation model and bounds on dimensionless groups

BIOPHYSICAL JOURNAL, 86(1), 589–598.

By: J. Haugh n  & I. Schneider n

MeSH headings : Animals; Cells, Cultured; Computer Simulation; Diffusion; Fibroblasts / drug effects; Fibroblasts / metabolism; Humans; Microscopy, Fluorescence / methods; Models, Biological; Phosphatidylinositols / metabolism; Platelet-Derived Growth Factor / pharmacology; Reproducibility of Results; Sensitivity and Specificity; Signal Transduction / physiology; Tissue Distribution
TL;DR: A comprehensive model describing the dynamics of 3' phosphoinositides, lipid second messengers produced in the plasma membrane in response to stimulation of the PI 3-kinase signaling pathway is presented, as monitored in the cell-substratum contact area using total internal reflection fluorescence microscopy. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2004 journal article

Spatial analysis of 3 ' phosphoinositide signaling in living fibroblasts: II. Parameter estimates for individual cells from experiments

BIOPHYSICAL JOURNAL, 86(1), 599–608.

By: I. Schneider n & J. Haugh n 

MeSH headings : Cells, Cultured; Computer Simulation; Diffusion; Fibroblasts / drug effects; Fibroblasts / metabolism; Humans; Microscopy, Fluorescence / methods; Models, Biological; Phosphatidylinositols / metabolism; Platelet-Derived Growth Factor / pharmacology; Reproducibility of Results; Sensitivity and Specificity; Signal Transduction / physiology; Tissue Distribution
TL;DR: 3' PI turnover is not affected by PDGF receptor signaling in the authors' cells, allowing us to focus their attention on the regulation of 3' PI production as this system is studied further. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2003 journal article

Kinetic analysis of platelet-derived growth factor receptor/phosphoinositide 3-kinase/Akt signaling in fibroblasts

JOURNAL OF BIOLOGICAL CHEMISTRY, 278(39), 37064–37072.

By: C. Park n, I. Schneider n & J. Haugh n 

MeSH headings : 3T3 Cells; Animals; Fibroblasts / physiology; Kinetics; Mathematics; Mice; Models, Biological; Phosphatidylinositol 3-Kinases / physiology; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins / physiology; Proto-Oncogene Proteins c-akt; Receptors, Platelet-Derived Growth Factor / physiology; Signal Transduction / physiology
TL;DR: It is found that PDGF receptor phosphorylation exhibits positive cooperativity with respect to PDGF concentration, and its kinetics are quantitatively consistent with a mechanism in which receptor dimerization is initially mediated by the association of two 1:1 PDGF/PDGF receptor complexes. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

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