Works (3)

Updated: July 5th, 2023 15:59

2006 journal article

Gene selection using support vector machines with non-convex penalty

BIOINFORMATICS, 22(1), 88–95.

By: H. Zhang n, J. Ahn*, X. Lin* & C. Park*

MeSH headings : Algorithms; Bayes Theorem; Cluster Analysis; Databases, Genetic; Humans; Models, Genetic; Models, Statistical; Neoplasms / genetics; Neoplasms / metabolism; Oligonucleotide Array Sequence Analysis / methods; Pattern Recognition, Automated; Sequence Analysis, DNA; Software; Time Factors
TL;DR: A unified procedure for simultaneous gene selection and cancer classification is provided, achieving high accuracy in both aspects and a successive quadratic algorithm is proposed to convert the non-differentiable and non-convex optimization problem into easily solved linear equation systems. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Quantitative model of Ras-phosphoinositide 3-kinase signalling cross-talk based on co-operative molecular assembly

BIOCHEMICAL JOURNAL, 393(1), 235–243.

By: H. Kaur n, C. Park n, J. Lewis n & J. Haugh n

author keywords: mathematical modelling; phosphoinositide 3-kinase (PI3K); platelet-derived growth factor (PDGF); Ras; receptor tyrosine kinase; signal transduction
MeSH headings : Animals; Mice; Models, Biological; NIH 3T3 Cells; Phosphatidylinositol 3-Kinases / metabolism; Proto-Oncogene Proteins c-akt / metabolism; Receptors, Platelet-Derived Growth Factor / metabolism; Signal Transduction; ras GTPase-Activating Proteins / metabolism
TL;DR: Experiments with platelet-derived growth factor-stimulated fibroblasts revealed that Ras apparently enhances the affinity of PI3K for receptors, which suggests that a ternary complex does indeed form, with the second step greatly enhanced through membrane localization and possibly allosteric effects. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2003 journal article

Kinetic analysis of platelet-derived growth factor receptor/phosphoinositide 3-kinase/Akt signaling in fibroblasts


By: C. Park n, I. Schneider* & J. Haugh n

MeSH headings : 3T3 Cells; Animals; Fibroblasts / physiology; Kinetics; Mathematics; Mice; Models, Biological; Phosphatidylinositol 3-Kinases / physiology; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins / physiology; Proto-Oncogene Proteins c-akt; Receptors, Platelet-Derived Growth Factor / physiology; Signal Transduction / physiology
TL;DR: It is found that PDGF receptor phosphorylation exhibits positive cooperativity with respect to PDGF concentration, and its kinetics are quantitatively consistent with a mechanism in which receptor dimerization is initially mediated by the association of two 1:1 PDGF/PDGF receptor complexes. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

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