Works (3)
Updated: July 5th, 2023 15:59
2005 journal article
Gene selection using support vector machines with non-convex penalty
BIOINFORMATICS, 22(1), 88–95.
MeSH headings : Algorithms; Bayes Theorem; Cluster Analysis; Databases, Genetic; Humans; Models, Genetic; Models, Statistical; Neoplasms / genetics; Neoplasms / metabolism; Oligonucleotide Array Sequence Analysis / methods; Pattern Recognition, Automated; Sequence Analysis, DNA; Software; Time Factors
TL;DR:
A unified procedure for simultaneous gene selection and cancer classification is provided, achieving high accuracy in both aspects and a successive quadratic algorithm is proposed to convert the non-differentiable and non-convex optimization problem into easily solved linear equation systems.
(via Semantic Scholar)
open access via academic.oup.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2005 journal article
Quantitative model of Ras-phosphoinositide 3-kinase signalling cross-talk based on co-operative molecular assembly
BIOCHEMICAL JOURNAL, 393(1), 235–243.
author keywords: mathematical modelling; phosphoinositide 3-kinase (PI3K); platelet-derived growth factor (PDGF); Ras; receptor tyrosine kinase; signal transduction
MeSH headings : Animals; Mice; Models, Biological; NIH 3T3 Cells; Phosphatidylinositol 3-Kinases / metabolism; Proto-Oncogene Proteins c-akt / metabolism; Receptors, Platelet-Derived Growth Factor / metabolism; Signal Transduction; ras GTPase-Activating Proteins / metabolism
TL;DR:
Experiments with platelet-derived growth factor-stimulated fibroblasts revealed that Ras apparently enhances the affinity of PI3K for receptors, which suggests that a ternary complex does indeed form, with the second step greatly enhanced through membrane localization and possibly allosteric effects.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2003 journal article
Kinetic analysis of platelet-derived growth factor receptor/phosphoinositide 3-kinase/Akt signaling in fibroblasts
JOURNAL OF BIOLOGICAL CHEMISTRY, 278(39), 37064–37072.
MeSH headings : 3T3 Cells; Animals; Fibroblasts / physiology; Kinetics; Mathematics; Mice; Models, Biological; Phosphatidylinositol 3-Kinases / physiology; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins / physiology; Proto-Oncogene Proteins c-akt; Receptors, Platelet-Derived Growth Factor / physiology; Signal Transduction / physiology
TL;DR:
It is found that PDGF receptor phosphorylation exhibits positive cooperativity with respect to PDGF concentration, and its kinetics are quantitatively consistent with a mechanism in which receptor dimerization is initially mediated by the association of two 1:1 PDGF/PDGF receptor complexes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
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