Jason M. Andrus
Works (3)
Updated: July 5th, 2023 15:58
2007 journal article
Anti-inflammatory properties of Lactobacillus gasseri expressing manganese superoxide dismutase using the interleukin 10-deficient mouse model of colitis
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 293(4), G729–G738.
Contributors: I. Carroll *, *, J. Bruno-Bárcena n , T. Klaenhammer n, H. Hassan n & D. Threadgill *
author keywords: probiotic; Lactobacilli; oxidative stress; inflammatory bowel disease
MeSH headings : Animals; Anti-Inflammatory Agents / therapeutic use; Colitis / drug therapy; Colitis / pathology; Colon / pathology; Cyclooxygenase 2 / metabolism; Disease Models, Animal; Immunohistochemistry; Interleukin-10 / deficiency; Lactobacillus / enzymology; Mice; Peroxidase / metabolism; Probiotics / therapeutic use; Specific Pathogen-Free Organisms; Superoxide Dismutase / biosynthesis; Superoxide Dismutase / therapeutic use
TL;DR:
This study demonstrates that L. gasseri producing MnSOD has significant anti-inflammatory activity that reduces the severity of colitis in the IL-10-deficient mouse.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2004 journal article
Expression of a heterologous manganese superoxide dismutase gene in intestinal lactobacilli provides protection against hydrogen peroxide toxicity
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 70(8), 4702–4710.
Contributors: J. Bruno-Bárcena* , *, S. Libby*, T. Klaenhammer n & H. Hassan n
MeSH headings : Cloning, Molecular; Humans; Hydrogen Peroxide / pharmacology; Intestines / microbiology; Lactobacillus / classification; Lactobacillus / drug effects; Lactobacillus / enzymology; Lactobacillus / genetics; Oxidative Stress / drug effects; Protein Biosynthesis; Streptococcus / enzymology; Streptococcus / genetics; Superoxide Dismutase / genetics; Superoxide Dismutase / metabolism; Transcription, Genetic
TL;DR:
The data show that MnSOD protects cells against hydrogen peroxide by removing O2·− and preventing the redox cycling of iron and is the first report of a sodA from S. thermophilus being expressed in other lactic acid bacteria.
(via Semantic Scholar)
open access via aem.asm.org (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2003 journal article
Molecular characterization and functional analysis of the manganese-containing superoxide dismutase gene (sodA) from Streptococcus thermophilus AO54
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 420(1), 103–113.
author keywords: Streptococcus thermophilus; superoxide dismutase; MnSOD; sodA sequence; sodA mutant; SOD-null mutant; oxygen sensitivity; manganese ions; DNA polymerase III
MeSH headings : Amino Acid Sequence; Gene Expression Regulation, Enzymologic / drug effects; Magnesium Chloride / pharmacology; Molecular Sequence Data; Mutagenesis, Site-Directed; Sequence Alignment; Sequence Analysis, Protein; Species Specificity; Streptococcus / chemistry; Streptococcus / drug effects; Streptococcus / enzymology; Streptococcus / genetics; Structure-Activity Relationship; Superoxide Dismutase / chemistry; Superoxide Dismutase / genetics; Superoxide Dismutase / metabolism
TL;DR:
The results suggest that sodA is essential for the aerobic growth of S. thermophilus and in the absence of functional SodA, manganese ions may provide partial protection against oxygen toxicity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
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