Works (1)
Updated: July 5th, 2023 15:58
2004 journal article
The effect of substitution patterns on the release rates of opioid peptides DADLE and [Leu(5)]-enkephalin from coumarin prodrug moieties
BIOORGANIC CHEMISTRY, 32(2), 109–123.
author keywords: coumarin; cyclic prodrug; opioid peptide; esterase; structural effect
MeSH headings : Coumarins / chemistry; Coumarins / metabolism; Enkephalin, Leucine-2-Alanine / analogs & derivatives; Enkephalin, Leucine-2-Alanine / chemical synthesis; Enkephalin, Leucine-2-Alanine / chemistry; Enkephalin, Leucine-2-Alanine / metabolism; Enkephalins / chemical synthesis; Enkephalins / chemistry; Enkephalins / metabolism; Esterases / metabolism; Kinetics; Molecular Structure; Prodrugs / chemical synthesis; Prodrugs / chemistry; Prodrugs / metabolism
TL;DR:
Aimed at further understanding the structure-release rate relationship of the coumarin-based cyclic prodrugs, a series of substituted coumarinic acid derivatives of opioid peptides, DADLE, and [Leu(5)]-enkephalin are synthesized and examined.
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Added: August 6, 2018
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