Everardo Macias

Works (6)

Updated: July 5th, 2023 15:58

2008 journal article

CDK2 activation in mouse epidermis induces keratinocyte proliferation but does not affect skin tumor development

AMERICAN JOURNAL OF PATHOLOGY, 173(2), 526–535.

By: E. Macias n, P. Marval*, A. De Siervi *, C. Conti *, A. Senderowicz* & M. Rodriguez-Puebla n

MeSH headings : 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Proliferation; Cell Transformation, Neoplastic / metabolism; Cell Transformation, Neoplastic / pathology; Cyclin-Dependent Kinase 2 / genetics; Cyclin-Dependent Kinase 2 / metabolism; Cyclin-Dependent Kinase Inhibitor p21 / metabolism; Cyclin-Dependent Kinase Inhibitor p27 / metabolism; Enzyme Activation; Epidermis / enzymology; Epidermis / pathology; Keratinocytes / enzymology; Keratinocytes / pathology; Mice; Mice, Transgenic; Mutation; Skin Neoplasms / chemically induced; Skin Neoplasms / enzymology; Skin Neoplasms / pathology
TL;DR: Although the indirect activation of CDK2 is sufficient to induce keratinocyte hyperproliferation, activation ofCDK2 alone does not induce malignant progression in Ras-mediated tumorigenesis, and Surprisingly, it is found that neither CDK 2 overexpression nor the indirectactivation of CDk2 enhanced skin tumor development. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Expression of CDK4 or CDK2 in mouse oral cavity is retained in adult pituitary with distinct effects on tumorigenesis

CANCER RESEARCH, 68(1), 162–171.

By: E. Macias n, P. Marva*, A. Senderowicz*, J. Cullen n & M. Rodriguez-Puebla n

MeSH headings : Animals; Cell Count; Cell Transformation, Neoplastic / genetics; Cell Transformation, Neoplastic / metabolism; Cyclin-Dependent Kinase 2 / analysis; Cyclin-Dependent Kinase 2 / genetics; Cyclin-Dependent Kinase 2 / metabolism; Cyclin-Dependent Kinase 4 / analysis; Cyclin-Dependent Kinase 4 / genetics; Cyclin-Dependent Kinase 4 / metabolism; Cyclin-Dependent Kinase Inhibitor p27 / genetics; Cyclin-Dependent Kinase Inhibitor p27 / metabolism; Humans; Mice; Mice, Transgenic; Mouth / embryology; Mouth / enzymology; Pituitary Gland / enzymology; Pituitary Neoplasms / enzymology; Pituitary Neoplasms / genetics; Promoter Regions, Genetic; Stem Cells
TL;DR: It is shown that deregulation of CDK expression in the primitive oral epithelium plays a unique function, providing a selective advantage that gives rise to transgene-positive TA-like pituitary cells. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Robe of Cyclin D1 as a Mediator of c-Met- and beta-Catenin-Induced Hepatocarcinogenesis

CANCER RESEARCH, 69(1), 253–261.

By: M. Patil, S. Lee, E. Macias n, E. Lam, C. Xu *, K. Jones *, C. Ho, M. Rodriguez-Puebla n, X. Chen*

MeSH headings : Animals; Cell Transformation, Neoplastic / genetics; Cell Transformation, Neoplastic / metabolism; Cyclin D1 / biosynthesis; Cyclin D1 / genetics; Cyclin D2; Cyclins / biosynthesis; Cyclins / genetics; Disease Models, Animal; Female; Humans; Liver Neoplasms, Experimental / genetics; Liver Neoplasms, Experimental / metabolism; Male; Mice; Mice, Transgenic; Proto-Oncogene Proteins c-met / biosynthesis; Proto-Oncogene Proteins c-met / genetics; Transfection; Up-Regulation; beta Catenin / biosynthesis; beta Catenin / genetics
TL;DR: The results suggest that CCND1 functions as a mediator of beta-catenin during HCC pathogenesis, although other molecules may be required to fully propagate beta-Catenin signaling. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Cdk2 deficiency decreases ras/CDK4-dependent malignant progression, but not myc-induced tumorigenesis

CANCER RESEARCH, 67(20), 9713–9720.

By: E. Macias n, Y. Kim n, P. Marval*, A. Klein-Szanto * & M. Rodriguez-Puebla n

MeSH headings : Animals; Carcinogens; Carcinoma, Squamous Cell / enzymology; Carcinoma, Squamous Cell / metabolism; Carcinoma, Squamous Cell / pathology; Cell Transformation, Neoplastic / metabolism; Cell Transformation, Neoplastic / pathology; Cyclin-Dependent Kinase 2 / deficiency; Cyclin-Dependent Kinase 2 / metabolism; Cyclin-Dependent Kinase 4 / metabolism; Cyclin-Dependent Kinase Inhibitor p21 / metabolism; Cyclin-Dependent Kinase Inhibitor p27 / metabolism; Disease Progression; Enzyme Activation; Female; Male; Mice; Mice, Transgenic; Proto-Oncogene Proteins c-myc / biosynthesis; Proto-Oncogene Proteins c-myc / genetics; Proto-Oncogene Proteins c-myc / metabolism; Skin Neoplasms / chemically induced; Skin Neoplasms / enzymology; Skin Neoplasms / pathology; Tetradecanoylphorbol Acetate; ras Proteins / metabolism
TL;DR: Overall, it is established that ras-induced tumors are more susceptible to CDK2 ablation than myc-induced tumorigenesis, suggesting that the efficacy of targetingCDK2 in tumor development and malignant progression is dependent on the oncogenic pathway involved. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2004 journal article

Lack of cyclin-dependent kinase 4 inhibits c-myc tumorigenic activities in epithelial tissues

MOLECULAR AND CELLULAR BIOLOGY, 24(17), 7538–7547.

By: P. Marval n, E. Macias n, R. Rounbehler*, P. Sicinski *, H. Kiyokawa *, D. Johnson *, C. Conti *, M. Rodriguez-Puebla  n

MeSH headings : Animals; Cell Cycle / physiology; Cell Cycle Proteins / metabolism; Cell Division / physiology; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinases / antagonists & inhibitors; Cyclin-Dependent Kinases / genetics; Cyclin-Dependent Kinases / metabolism; Cyclins / metabolism; Epidermal Cells; Epidermis / metabolism; Epidermis / pathology; Epithelium / metabolism; Epithelium / pathology; Humans; Keratinocytes / cytology; Keratinocytes / metabolism; Mice; Mice, Inbred C57BL; Mice, Transgenic; Phenotype; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-myc / genetics; Proto-Oncogene Proteins c-myc / metabolism; Skin Neoplasms / genetics; Skin Neoplasms / metabolism; Tumor Suppressor Proteins / metabolism
TL;DR: Results show that CDK4 mediates the proliferative and oncogenic activities of Myc in vivo through a mechanism that involves the sequestration of specific CDK inhibitors. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2003 journal article

Enhanced malignant tumorigenesis in Cdk4 transgenic mice

ONCOGENE, 23(10), 1863–1873.

By: P. Marval n, E. Macias n, C. Conti * & M. Rodriguez-Puebla n

author keywords: CDK4; carcinogenesis; skin; cell-cycle; cyclin; papillomas
MeSH headings : Animals; Carcinoma / genetics; Carcinoma / pathology; Carcinoma, Squamous Cell / genetics; Carcinoma, Squamous Cell / pathology; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinases / genetics; Humans; Mice; Mice, Transgenic; Papilloma / genetics; Papilloma / pathology; Proto-Oncogene Proteins; Skin Neoplasms / genetics; Skin Neoplasms / pathology
TL;DR: The results indicate that, contrary to the general assumption, the catalytic subunit,CDK4, has higher oncogenic activity than cyclin D1, revealing a potential use of CDK4 as therapeutic target. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

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