Everardo Macias

Works (6)

Updated: July 5th, 2023 15:58

2008 journal article

CDK2 activation in mouse epidermis induces keratinocyte proliferation but does not affect skin tumor development

AMERICAN JOURNAL OF PATHOLOGY, 173(2), 526–535.

By: E. Macias n, P. Marval*, A. De Siervi *, C. Conti *, A. Senderowicz* & M. Rodriguez-Puebla n

MeSH headings : 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Proliferation; Cell Transformation, Neoplastic / metabolism; Cell Transformation, Neoplastic / pathology; Cyclin-Dependent Kinase 2 / genetics; Cyclin-Dependent Kinase 2 / metabolism; Cyclin-Dependent Kinase Inhibitor p21 / metabolism; Cyclin-Dependent Kinase Inhibitor p27 / metabolism; Enzyme Activation; Epidermis / enzymology; Epidermis / pathology; Keratinocytes / enzymology; Keratinocytes / pathology; Mice; Mice, Transgenic; Mutation; Skin Neoplasms / chemically induced; Skin Neoplasms / enzymology; Skin Neoplasms / pathology
TL;DR: Although the indirect activation of CDK2 is sufficient to induce keratinocyte hyperproliferation, activation ofCDK2 alone does not induce malignant progression in Ras-mediated tumorigenesis, and Surprisingly, it is found that neither CDK 2 overexpression nor the indirectactivation of CDk2 enhanced skin tumor development. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2008 journal article

Expression of CDK4 or CDK2 in mouse oral cavity is retained in adult pituitary with distinct effects on tumorigenesis

CANCER RESEARCH, 68(1), 162–171.

By: E. Macias n, P. Marva*, A. Senderowicz*, J. Cullen n & M. Rodriguez-Puebla n

MeSH headings : Animals; Cell Count; Cell Transformation, Neoplastic / genetics; Cell Transformation, Neoplastic / metabolism; Cyclin-Dependent Kinase 2 / analysis; Cyclin-Dependent Kinase 2 / genetics; Cyclin-Dependent Kinase 2 / metabolism; Cyclin-Dependent Kinase 4 / analysis; Cyclin-Dependent Kinase 4 / genetics; Cyclin-Dependent Kinase 4 / metabolism; Cyclin-Dependent Kinase Inhibitor p27 / genetics; Cyclin-Dependent Kinase Inhibitor p27 / metabolism; Humans; Mice; Mice, Transgenic; Mouth / embryology; Mouth / enzymology; Pituitary Gland / enzymology; Pituitary Neoplasms / enzymology; Pituitary Neoplasms / genetics; Promoter Regions, Genetic; Stem Cells
TL;DR: It is shown that deregulation of CDK expression in the primitive oral epithelium plays a unique function, providing a selective advantage that gives rise to transgene-positive TA-like pituitary cells. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Robe of Cyclin D1 as a Mediator of c-Met- and beta-Catenin-Induced Hepatocarcinogenesis

CANCER RESEARCH, 69(1), 253–261.

By: M. Patil, S. Lee, E. Macias n, E. Lam, C. Xu *, K. Jones *, C. Ho, M. Rodriguez-Puebla n, X. Chen*

MeSH headings : Animals; Cell Transformation, Neoplastic / genetics; Cell Transformation, Neoplastic / metabolism; Cyclin D1 / biosynthesis; Cyclin D1 / genetics; Cyclin D2; Cyclins / biosynthesis; Cyclins / genetics; Disease Models, Animal; Female; Humans; Liver Neoplasms, Experimental / genetics; Liver Neoplasms, Experimental / metabolism; Male; Mice; Mice, Transgenic; Proto-Oncogene Proteins c-met / biosynthesis; Proto-Oncogene Proteins c-met / genetics; Transfection; Up-Regulation; beta Catenin / biosynthesis; beta Catenin / genetics
TL;DR: The results suggest that CCND1 functions as a mediator of beta-catenin during HCC pathogenesis, although other molecules may be required to fully propagate beta-Catenin signaling. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Cdk2 deficiency decreases ras/CDK4-dependent malignant progression, but not myc-induced tumorigenesis

CANCER RESEARCH, 67(20), 9713–9720.

By: E. Macias n, Y. Kim n, P. Marval*, A. Klein-Szanto * & M. Rodriguez-Puebla n

MeSH headings : Animals; Carcinogens; Carcinoma, Squamous Cell / enzymology; Carcinoma, Squamous Cell / metabolism; Carcinoma, Squamous Cell / pathology; Cell Transformation, Neoplastic / metabolism; Cell Transformation, Neoplastic / pathology; Cyclin-Dependent Kinase 2 / deficiency; Cyclin-Dependent Kinase 2 / metabolism; Cyclin-Dependent Kinase 4 / metabolism; Cyclin-Dependent Kinase Inhibitor p21 / metabolism; Cyclin-Dependent Kinase Inhibitor p27 / metabolism; Disease Progression; Enzyme Activation; Female; Male; Mice; Mice, Transgenic; Proto-Oncogene Proteins c-myc / biosynthesis; Proto-Oncogene Proteins c-myc / genetics; Proto-Oncogene Proteins c-myc / metabolism; Skin Neoplasms / chemically induced; Skin Neoplasms / enzymology; Skin Neoplasms / pathology; Tetradecanoylphorbol Acetate; ras Proteins / metabolism
TL;DR: Overall, it is established that ras-induced tumors are more susceptible to CDK2 ablation than myc-induced tumorigenesis, suggesting that the efficacy of targetingCDK2 in tumor development and malignant progression is dependent on the oncogenic pathway involved. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2004 journal article

Lack of cyclin-dependent kinase 4 inhibits c-myc tumorigenic activities in epithelial tissues

MOLECULAR AND CELLULAR BIOLOGY, 24(17), 7538–7547.

By: P. Marval n, E. Macias n, R. Rounbehler*, P. Sicinski *, H. Kiyokawa *, D. Johnson *, C. Conti *, M. Rodriguez-Puebla  n

MeSH headings : Animals; Cell Cycle / physiology; Cell Cycle Proteins / metabolism; Cell Division / physiology; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinases / antagonists & inhibitors; Cyclin-Dependent Kinases / genetics; Cyclin-Dependent Kinases / metabolism; Cyclins / metabolism; Epidermal Cells; Epidermis / metabolism; Epidermis / pathology; Epithelium / metabolism; Epithelium / pathology; Humans; Keratinocytes / cytology; Keratinocytes / metabolism; Mice; Mice, Inbred C57BL; Mice, Transgenic; Phenotype; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-myc / genetics; Proto-Oncogene Proteins c-myc / metabolism; Skin Neoplasms / genetics; Skin Neoplasms / metabolism; Tumor Suppressor Proteins / metabolism
TL;DR: Results show that CDK4 mediates the proliferative and oncogenic activities of Myc in vivo through a mechanism that involves the sequestration of specific CDK inhibitors. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2003 journal article

Enhanced malignant tumorigenesis in Cdk4 transgenic mice

ONCOGENE, 23(10), 1863–1873.

By: P. Marval n, E. Macias n, C. Conti * & M. Rodriguez-Puebla n

author keywords: CDK4; carcinogenesis; skin; cell-cycle; cyclin; papillomas
MeSH headings : Animals; Carcinoma / genetics; Carcinoma / pathology; Carcinoma, Squamous Cell / genetics; Carcinoma, Squamous Cell / pathology; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinases / genetics; Humans; Mice; Mice, Transgenic; Papilloma / genetics; Papilloma / pathology; Proto-Oncogene Proteins; Skin Neoplasms / genetics; Skin Neoplasms / pathology
TL;DR: The results indicate that, contrary to the general assumption, the catalytic subunit,CDK4, has higher oncogenic activity than cyclin D1, revealing a potential use of CDK4 as therapeutic target. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

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