Works (4)
Updated: July 5th, 2023 15:58
2012 journal article
Combined effect of cyclin D3 expression and abrogation of cyclin D1 prevent mouse skin tumor development
CELL CYCLE, 11(2), 335–342.
author keywords: cell cycle; D-type cyclins; skin; carcinogenesis; epidermis
MeSH headings : 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma, Squamous Cell / chemically induced; Carcinoma, Squamous Cell / metabolism; Carcinoma, Squamous Cell / pathology; Cell Proliferation; Cell Transformation, Neoplastic; Cyclin D1 / genetics; Cyclin D1 / metabolism; Cyclin D2 / metabolism; Cyclin D3 / genetics; Cyclin D3 / metabolism; Gene Expression Regulation; Mice; Mice, Transgenic; Oncogene Protein p21(ras) / genetics; Papilloma / chemically induced; Papilloma / metabolism; Papilloma / pathology; Skin / pathology; Skin Neoplasms / chemically induced; Skin Neoplasms / metabolism; Skin Neoplasms / pathology; Tumor Burden
TL;DR:
Modulation of the levels of particular members of the D-type cyclin family could be useful to inhibit tumor development and, in particular, ras-mediated tumorigenesis.
(via Semantic Scholar)
open access via europepmc.org (repository)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2007 journal article
Cdk2 deficiency decreases ras/CDK4-dependent malignant progression, but not myc-induced tumorigenesis
CANCER RESEARCH, 67(20), 9713–9720.
MeSH headings : Animals; Carcinogens; Carcinoma, Squamous Cell / enzymology; Carcinoma, Squamous Cell / metabolism; Carcinoma, Squamous Cell / pathology; Cell Transformation, Neoplastic / metabolism; Cell Transformation, Neoplastic / pathology; Cyclin-Dependent Kinase 2 / deficiency; Cyclin-Dependent Kinase 2 / metabolism; Cyclin-Dependent Kinase 4 / metabolism; Cyclin-Dependent Kinase Inhibitor p21 / metabolism; Cyclin-Dependent Kinase Inhibitor p27 / metabolism; Disease Progression; Enzyme Activation; Female; Male; Mice; Mice, Transgenic; Proto-Oncogene Proteins c-myc / biosynthesis; Proto-Oncogene Proteins c-myc / genetics; Proto-Oncogene Proteins c-myc / metabolism; Skin Neoplasms / chemically induced; Skin Neoplasms / enzymology; Skin Neoplasms / pathology; Tetradecanoylphorbol Acetate; ras Proteins / metabolism
TL;DR:
Overall, it is established that ras-induced tumors are more susceptible to CDK2 ablation than myc-induced tumorigenesis, suggesting that the efficacy of targetingCDK2 in tumor development and malignant progression is dependent on the oncogenic pathway involved.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2004 journal article
Lack of cyclin-dependent kinase 4 inhibits c-myc tumorigenic activities in epithelial tissues
MOLECULAR AND CELLULAR BIOLOGY, 24(17), 7538–7547.
MeSH headings : Animals; Cell Cycle / physiology; Cell Cycle Proteins / metabolism; Cell Division / physiology; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinases / antagonists & inhibitors; Cyclin-Dependent Kinases / genetics; Cyclin-Dependent Kinases / metabolism; Cyclins / metabolism; Epidermal Cells; Epidermis / metabolism; Epidermis / pathology; Epithelium / metabolism; Epithelium / pathology; Humans; Keratinocytes / cytology; Keratinocytes / metabolism; Mice; Mice, Inbred C57BL; Mice, Transgenic; Phenotype; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-myc / genetics; Proto-Oncogene Proteins c-myc / metabolism; Skin Neoplasms / genetics; Skin Neoplasms / metabolism; Tumor Suppressor Proteins / metabolism
TL;DR:
Results show that CDK4 mediates the proliferative and oncogenic activities of Myc in vivo through a mechanism that involves the sequestration of specific CDK inhibitors.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2003 journal article
Enhanced malignant tumorigenesis in Cdk4 transgenic mice
ONCOGENE, 23(10), 1863–1873.
author keywords: CDK4; carcinogenesis; skin; cell-cycle; cyclin; papillomas
MeSH headings : Animals; Carcinoma / genetics; Carcinoma / pathology; Carcinoma, Squamous Cell / genetics; Carcinoma, Squamous Cell / pathology; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinases / genetics; Humans; Mice; Mice, Transgenic; Papilloma / genetics; Papilloma / pathology; Proto-Oncogene Proteins; Skin Neoplasms / genetics; Skin Neoplasms / pathology
TL;DR:
The results indicate that, contrary to the general assumption, the catalytic subunit,CDK4, has higher oncogenic activity than cyclin D1, revealing a potential use of CDK4 as therapeutic target.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
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