Paula L. Miliani De Marval

Works (4)

Updated: July 5th, 2023 15:58

2012 article

Combined effect of cyclin D3 expression and abrogation of cyclin D1 prevent mouse skin tumor development

Wang, X., Sistrunk, C., Marval, P. L. M., Kim, Y., & Rodriguez-Puebla, M. L. (2012, January 15). Cell Cycle.

By: X. Wang n, C. Sistrunk  n, P. Marval*, Y. Kim* & M. Rodriguez-Puebla n

author keywords: cell cycle; D-type cyclins; skin; carcinogenesis; epidermis
MeSH headings : 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma, Squamous Cell / chemically induced; Carcinoma, Squamous Cell / metabolism; Carcinoma, Squamous Cell / pathology; Cell Proliferation; Cell Transformation, Neoplastic; Cyclin D1 / genetics; Cyclin D1 / metabolism; Cyclin D2 / metabolism; Cyclin D3 / genetics; Cyclin D3 / metabolism; Gene Expression Regulation; Mice; Mice, Transgenic; Oncogene Protein p21(ras) / genetics; Papilloma / chemically induced; Papilloma / metabolism; Papilloma / pathology; Skin / pathology; Skin Neoplasms / chemically induced; Skin Neoplasms / metabolism; Skin Neoplasms / pathology; Tumor Burden
topics (OpenAlex): Cancer-related Molecular Pathways; Microtubule and mitosis dynamics; Ubiquitin and proteasome pathways
TL;DR: Modulation of the levels of particular members of the D-type cyclin family could be useful to inhibit tumor development and, in particular, ras-mediated tumorigenesis. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2007 article

Cdk2 Deficiency Decreases ras/CDK4-Dependent Malignant Progression, but Not myc-Induced Tumorigenesis

Macias, E., Kim, Y., Marval, P. L. M., Klein-Szanto, A., & Rodriguez-Puebla, M. L. (2007, October 15). Cancer Research.

By: E. Macias n, Y. Kim n, P. Marval*, A. Klein-Szanto * & M. Rodriguez-Puebla n

MeSH headings : Animals; Carcinogens; Carcinoma, Squamous Cell / enzymology; Carcinoma, Squamous Cell / metabolism; Carcinoma, Squamous Cell / pathology; Cell Transformation, Neoplastic / metabolism; Cell Transformation, Neoplastic / pathology; Cyclin-Dependent Kinase 2 / deficiency; Cyclin-Dependent Kinase 2 / metabolism; Cyclin-Dependent Kinase 4 / metabolism; Cyclin-Dependent Kinase Inhibitor p21 / metabolism; Cyclin-Dependent Kinase Inhibitor p27 / metabolism; Disease Progression; Enzyme Activation; Female; Male; Mice; Mice, Transgenic; Proto-Oncogene Proteins c-myc / biosynthesis; Proto-Oncogene Proteins c-myc / genetics; Proto-Oncogene Proteins c-myc / metabolism; Skin Neoplasms / chemically induced; Skin Neoplasms / enzymology; Skin Neoplasms / pathology; Tetradecanoylphorbol Acetate; ras Proteins / metabolism
topics (OpenAlex): Cancer-related Molecular Pathways; Cancer and Skin Lesions; Hedgehog Signaling Pathway Studies
TL;DR: Overall, it is established that ras-induced tumors are more susceptible to CDK2 ablation than myc-induced tumorigenesis, suggesting that the efficacy of targetingCDK2 in tumor development and malignant progression is dependent on the oncogenic pathway involved. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2004 article

Lack of Cyclin-Dependent Kinase 4 Inhibits c- myc Tumorigenic Activities in Epithelial Tissues

Marval, P. L. M., Macias, E., Rounbehler, R., Sicinski, P., Kiyokawa, H., Johnson, D. G., … Rodriguez-Puebla, M. L. (2004, August 16). Molecular and Cellular Biology.

By: P. Marval n, E. Macias n, R. Rounbehler*, P. Sicinski *, H. Kiyokawa *, D. Johnson *, C. Conti *, M. Rodriguez-Puebla  n

MeSH headings : Animals; Cell Cycle / physiology; Cell Cycle Proteins / metabolism; Cell Division / physiology; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinases / antagonists & inhibitors; Cyclin-Dependent Kinases / genetics; Cyclin-Dependent Kinases / metabolism; Cyclins / metabolism; Epidermal Cells; Epidermis / metabolism; Epidermis / pathology; Epithelium / metabolism; Epithelium / pathology; Humans; Keratinocytes / cytology; Keratinocytes / metabolism; Mice; Mice, Inbred C57BL; Mice, Transgenic; Phenotype; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-myc / genetics; Proto-Oncogene Proteins c-myc / metabolism; Skin Neoplasms / genetics; Skin Neoplasms / metabolism; Tumor Suppressor Proteins / metabolism
topics (OpenAlex): Cancer-related Molecular Pathways; Ubiquitin and proteasome pathways; Microtubule and mitosis dynamics
TL;DR: Results show that CDK4 mediates the proliferative and oncogenic activities of Myc in vivo through a mechanism that involves the sequestration of specific CDK inhibitors. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2003 article

Enhanced malignant tumorigenesis in Cdk4 transgenic mice

Marval, P. L. M., Macias, E., Conti, C. J., & Rodriguez-Puebla, M. L. (2003, December 1). Oncogene.

By: P. Marval n, E. Macias n, C. Conti * & M. Rodriguez-Puebla n

author keywords: CDK4; carcinogenesis; skin; cell-cycle; cyclin; papillomas
MeSH headings : Animals; Carcinoma / genetics; Carcinoma / pathology; Carcinoma, Squamous Cell / genetics; Carcinoma, Squamous Cell / pathology; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinases / genetics; Humans; Mice; Mice, Transgenic; Papilloma / genetics; Papilloma / pathology; Proto-Oncogene Proteins; Skin Neoplasms / genetics; Skin Neoplasms / pathology
topics (OpenAlex): Cancer-related Molecular Pathways; Ubiquitin and proteasome pathways; Microtubule and mitosis dynamics
TL;DR: The results indicate that, contrary to the general assumption, the catalytic subunit,CDK4, has higher oncogenic activity than cyclin D1, revealing a potential use of CDK4 as therapeutic target. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

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