Works (2)
Updated: July 5th, 2023 15:58
2005 journal article
Quantitative model of Ras-phosphoinositide 3-kinase signalling cross-talk based on co-operative molecular assembly
BIOCHEMICAL JOURNAL, 393(1), 235–243.
author keywords: mathematical modelling; phosphoinositide 3-kinase (PI3K); platelet-derived growth factor (PDGF); Ras; receptor tyrosine kinase; signal transduction
MeSH headings : Animals; Mice; Models, Biological; NIH 3T3 Cells; Phosphatidylinositol 3-Kinases / metabolism; Proto-Oncogene Proteins c-akt / metabolism; Receptors, Platelet-Derived Growth Factor / metabolism; Signal Transduction; ras GTPase-Activating Proteins / metabolism
TL;DR:
Experiments with platelet-derived growth factor-stimulated fibroblasts revealed that Ras apparently enhances the affinity of PI3K for receptors, which suggests that a ternary complex does indeed form, with the second step greatly enhanced through membrane localization and possibly allosteric effects.
(via Semantic Scholar)
open access via europepmc.org (repository)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2003 journal article
Single base oligodeoxyguanosine upregulates Fas ligand release by nonspecific cytotoxic cells
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 28(6), 571–579.
author keywords: nonspecific cytotoxic cells; single base oligos; oligodeoxyguanosine; soluble Fas ligand; Fas receptor; programmed cell death; annexin-V; DNA hypoploidy
MeSH headings : Animals; Apoptosis / immunology; Catfishes / immunology; Cytotoxicity, Immunologic / immunology; DNA Fragmentation / immunology; DNA, Bacterial / genetics; DNA, Bacterial / immunology; DNA, Bacterial / physiology; Deoxyguanosine / immunology; Fas Ligand Protein; Female; HL-60 Cells; Humans; K562 Cells; Male; Membrane Glycoproteins / biosynthesis; Membrane Glycoproteins / immunology; Membrane Glycoproteins / metabolism; Oligonucleotides / immunology; Up-Regulation; fas Receptor / immunology
TL;DR:
It is demonstrated that an NK like cell (NCC) produces and secretes sFasL following binding by single base oligodeoxyguanosine.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
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