Xiaohui Luo

Works (1)

Updated: July 5th, 2023 15:57

2004 journal article

Score tests for dose effect in the presence of non-responders

STATISTICS IN MEDICINE, 23(23), 3581–3591.

By: X. Luo n, D. Boos n  & R. Tamura*

author keywords: mixture model; likelihood ratio test; simple linear regression; EM algorithm; permutation test
MeSH headings : Algorithms; Benzodiazepines / administration & dosage; Biometry / methods; Clinical Trials as Topic / statistics & numerical data; Dose-Response Relationship, Drug; Humans; Injections, Intramuscular; Likelihood Functions; Linear Models; Models, Statistical; Monte Carlo Method; Olanzapine; Pharmaceutical Preparations / administration & dosage; Psychomotor Agitation / drug therapy; Schizophrenia / drug therapy
TL;DR: This paper focuses on hypothesis testing in a dose–response framework and shows that increased power is possible by using a mixture model where both the logit of the response rate and the response mean are linear functions of the dose level. (via Semantic Scholar)
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Added: August 6, 2018

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