Works (1)
Updated: July 5th, 2023 15:57
2004 journal article
Score tests for dose effect in the presence of non-responders
STATISTICS IN MEDICINE, 23(23), 3581–3591.
author keywords: mixture model; likelihood ratio test; simple linear regression; EM algorithm; permutation test
MeSH headings : Algorithms; Benzodiazepines / administration & dosage; Biometry / methods; Clinical Trials as Topic / statistics & numerical data; Dose-Response Relationship, Drug; Humans; Injections, Intramuscular; Likelihood Functions; Linear Models; Models, Statistical; Monte Carlo Method; Olanzapine; Pharmaceutical Preparations / administration & dosage; Psychomotor Agitation / drug therapy; Schizophrenia / drug therapy
TL;DR:
This paper focuses on hypothesis testing in a dose–response framework and shows that increased power is possible by using a mixture model where both the logit of the response rate and the response mean are linear functions of the dose level.
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Source: Web Of Science
Added: August 6, 2018
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