Works (2)
Updated: July 5th, 2023 15:57
2005 article
Local Peroxynitrite Formation Contributes to Early Control of Cryptosporidium parvum Infection
Gookin, J. L., Allen, J., Chiang, S., Duckett, L., & Armstrong, M. U. (2005, June 22). Infection and Immunity, Vol. 73, pp. 3929–3936.
MeSH headings : Animals; Cryptosporidiosis / immunology; Cryptosporidium parvum; Female; Immunohistochemistry; Lipid Peroxidation; Nitric Oxide Synthase / analysis; Nitric Oxide Synthase Type II; Peroxynitrous Acid / biosynthesis; Swine; Tyrosine / metabolism
topics (OpenAlex): Parasitic Infections and Diagnostics; Coccidia and coccidiosis research; Helminth infection and control
TL;DR:
The present results are the first to demonstrate an in vivo role for peroxynitrite formation in acute mucosal defense against a noninvasive intestinal epithelial pathogen.
(via Semantic Scholar)
open access via iai.asm.org (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2005 article
NF-κB-mediated expression of iNOS promotes epithelial defense against infection byCryptosporidium parvumin neonatal piglets
Gookin, J. L., Chiang, S., Allen, J., Armstrong, M. U., Stauffer, S. H., Finnegan, C., & Murtaugh, M. P. (2005, August 26). American Journal of Physiology-Gastrointestinal and Liver Physiology, Vol. 290, pp. G164–174.
author keywords: nitric oxide; barrier function; diarrhea; cryptosporidiosis
MeSH headings : Animals; Animals, Newborn; Body Weight; Chlorides / metabolism; Cryptosporidiosis / enzymology; Cryptosporidiosis / metabolism; Cryptosporidium parvum / immunology; Epithelial Cells / metabolism; Gene Expression Regulation, Enzymologic; Ileum / cytology; Ileum / metabolism; Ileum / ultrastructure; Intestinal Mucosa / cytology; Intestinal Mucosa / metabolism; Intestinal Mucosa / pathology; NF-kappa B / metabolism; Nitric Oxide Synthase Type II / genetics; Nitric Oxide Synthase Type II / metabolism; Swine; Swine Diseases / enzymology; Swine Diseases / metabolism; Swine Diseases / parasitology
topics (OpenAlex): Parasitic Infections and Diagnostics; Coccidia and coccidiosis research; Helminth infection and control
TL;DR:
It is shown that mucosal expression of inducible nitric oxide (NO) synthase (iNOS) is increased in infected piglets and that inhibition of iNOS in vitro has no short-term effect on barrier function, suggesting that induction of i NOS represents a nonspecific response of the epithelium that mediates enterocyte defense against C. parvum infection.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018